The expanding role of PI3-kinase in bone
Golden LH, Insogna KL. The expanding role of PI3-kinase in bone. Bone 2004, 34: 3-12. PMID: 14751558, DOI: 10.1016/j.bone.2003.09.005.BooksConceptsRole of PI3PI3-KsC-fmsTyrosine kinase c-SrcKinase c-SrcDifferent substrate specificitiesCritical downstream effectorCell surface receptorsActin remodelingSignal transductionPI3-kinaseC-SrcSubstrate specificityDownstream effectorsOsteoblast differentiationCellular responsesPI3Attachment structuresEffector actionOsteoclast survivalRegulationRecent evidenceImportant roleTransductionRole