2001
[The role of transplanted astrocytes for the regeneration of CNS axons].
Imaizumi T, Lankford K, Kocsis J, Hashi K. [The role of transplanted astrocytes for the regeneration of CNS axons]. Brain And Nerve 脳と神経 2001, 53: 632-8. PMID: 11517487.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesAxonsCentral Nervous SystemElectrophysiologyNerve RegenerationRatsRats, WistarSchwann CellsConceptsCompound action potentialRegenerated axonsSC transplantationAxonal regenerationAdult ratsLong-tract axonsMyelin associated proteinsDorsal column axonsRegeneration of axonsDC axonsCell transplantationDorsal rootsNeonatal ratsSpinal cordReduction of scarsHistological examinationTransplantationMammalian CNSCNS axonsAction potentialsAxonsMyelin formationLesionsThree daysRatsTransplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord
Kohama I, Lankford K, Preiningerova J, White F, Vollmer T, Kocsis J. Transplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord. Journal Of Neuroscience 2001, 21: 944-950. PMID: 11157080, PMCID: PMC2605383, DOI: 10.1523/jneurosci.21-03-00944.2001.Peer-Reviewed Original ResearchConceptsHuman Schwann cellsSchwann cellsDorsal columnsSural nerveAxonal conductionIntra-axonal recording techniquesDorsal column lesionLegs of patientsDemyelinated spinal cordHuman sural nerveAdult human Schwann cellsFunctional remyelinationExtensive remyelinationCell-based therapiesMultiple sclerosisVascular diseaseSpinal cordWistar ratsConduction blockAdult CNSConduction velocityLesion zoneAction potentialsMonoclonal antibodiesLesions
2000
Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord
Imaizumi T, Lankford K, Burton W, Fodor W, Kocsis J. Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord. Nature Biotechnology 2000, 18: 949-953. PMID: 10973214, PMCID: PMC2605371, DOI: 10.1038/79432.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsCD59 AntigensCell SeparationElectrophysiologyFlow CytometryFluorescent Antibody Technique, IndirectHumansImmunosuppression TherapyModels, BiologicalOlfactory NerveRatsRats, WistarRegenerationSchwann CellsSciatic NerveSpinal CordSwineTransgenesTransplantation, HeterologousConceptsAxonal regenerationSpinal cordSchwann cellsImpulse conductionLesion-control ratsDorsal column lesionTransplantation of olfactoryRat spinal cordConduction velocity measurementsComplement inhibitory proteinsHyperacute responseRegenerated axonsImmunosuppressed ratsTransection siteLesion sitePeripheral patternHost tractCordNormal axonsDonor cellsAxonsInhibitory proteinRatsDonor cell typeTransgenic pigs[Characteristic improvement of the function following Schwann cell transplantation for demyelinated spinal cord].
Imaizumi T, Lankford K, Kocsis J, Honmou O, Kohama I, Hashi K. [Characteristic improvement of the function following Schwann cell transplantation for demyelinated spinal cord]. No Shinkei Geka. Neurological Surgery 2000, 28: 705-11. PMID: 11002493.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal rootsSchwann cellsSC transplantationSC myelinationAdult ratsConduction velocityTransplantation of SCsNormal DCsDorsal root ganglion neuronsDorsal column axonsLower conduction velocityGanglion neuronsSpinal cordDemyelinated axonsHistological examinationTransplantationAction potentialsRemyelinationAxonsOligodendrocytesRatsMyelinationAnatomical differencesLow amplitude[Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons].
Imaizumi T, Lankford K, Kocsis J, Sasaki M, Akiyama Y, Hashi K. [Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons]. Brain And Nerve 脳と神経 2000, 52: 609-15. PMID: 10934721.Peer-Reviewed Original ResearchConceptsDemyelinated CNS axonsSchwann cellsBrain cellsSpinal cordConduction velocityCNS axonsAdult rat spinal cordFronto-temporal lobesRat spinal cordAdult Schwann cellsDemyelination of axonsMyelin-forming cellsBlock of conductionAdult olfactoryDemyelinated diseasesDemyelinated axonsLess myelinationHistological examinationCNS tissueTherapeutic approachesStimulus trainsDay 28Transplanted OECsAmplitude decrementRemyelinationTransplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord
Imaizumi T, Lankford K, Kocsis J. Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord. Brain Research 2000, 854: 70-78. PMID: 10784108, DOI: 10.1016/s0006-8993(99)02285-4.Peer-Reviewed Original ResearchConceptsRegenerated axonsCell transplantationSpinal cordSchwann cellsTransection siteIsolated spinal cord preparationSpinal cord preparationTransplantation of olfactoryRat spinal cordSpinal cord axonsConduction velocity measurementsTransplantation of cellsCord preparationDorsal columnsAxonal regenerationAxon areaTransplantationImpulse conductionHost tractElectrophysiological recordingsAxonsNormal axonsDonor cellsNeuronal sourcesCord
1998
Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord
Imaizumi T, Lankford K, Waxman S, Greer C, Kocsis J. Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord. Journal Of Neuroscience 1998, 18: 6176-6185. PMID: 9698311, PMCID: PMC2605360, DOI: 10.1523/jneurosci.18-16-06176.1998.Peer-Reviewed Original ResearchConceptsDorsal column axonsRat spinal cordSpinal cordRemyelinated axonsDorsal columnsAdult rat spinal cordExtent of remyelinationTransplantation of OECsSpinal cord lesionsCell injection siteQuantitative histological analysisFunctional remyelinationCord lesionsAxonal conductionNeonatal ratsFocal injectionsConduction blockSchwann cellsConduction velocityInjection siteElectrophysiological propertiesAction potentialsAxonsHistological analysisTransplantationMechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion
Lankford K, Waxman S, Kocsis J. Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion. The Journal Of Comparative Neurology 1998, 391: 11-29. PMID: 9527536, PMCID: PMC2605358, DOI: 10.1002/(sici)1096-9861(19980202)391:1<11::aid-cne2>3.0.co;2-u.Peer-Reviewed Original ResearchConceptsDorsal root gangliaConditioning lesionNerve injuryNerve regenerationAffected dorsal root ganglionControl dorsal root gangliaDenervated peripheral nervePrior nerve injurySciatic nerve lesionCultured DRG neuronsSciatic nerve transectionPeripheral target tissuesPeripheral nerve stumpRapid nerve regenerationAbility of neuronsSecond axotomyNerve lesionsDRG neuronsNerve transectionNerve stumpRoot gangliaControl neuronsPeripheral nervesNerve tractsAdult rats
1994
Intracellular calcium mobilization and neurite outgrowth in mammalian neurons
Kocsis J, Rand M, Lankford K, Waxman S. Intracellular calcium mobilization and neurite outgrowth in mammalian neurons. Developmental Neurobiology 1994, 25: 252-264. PMID: 8195789, DOI: 10.1002/neu.480250306.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCaffeineCalciumCalcium ChannelsCell CompartmentationCell DifferentiationCells, CulturedFemaleGanglia, SpinalGene Expression RegulationImage Processing, Computer-AssistedIntracellular FluidIon Channel GatingLasersMicroscopy, FluorescenceModels, BiologicalNeuritesNeuronsRatsRats, WistarTerpenesThapsigarginConceptsDepolarization-induced Ca2Calcium-induced calcium releaseDRG neuronsIntracellular Ca2Cultured adult rat dorsal root ganglion neuronsAdult rat dorsal root ganglion neuronsRat dorsal root ganglion neuronsNeurite outgrowthDorsal root ganglion neuronsIntact intracellular Ca2Intracellular calcium mobilizationIndicator dye fluo-3Nuclear Ca2Dye Fluo-3Endoplasmic reticulum Ca2Ganglion neuronsCalcium mobilizationDependent kinase IICalcium releaseFluo-3NeuronsMammalian neuronsReticulum Ca2Elevated Ca2Elicit neurite outgrowthChapter 14 Nuclear calcium elevation may initiate neurite outgrowth in mammalian neurons
Kocsis J, Rand M, Lankford K, Waxman S. Chapter 14 Nuclear calcium elevation may initiate neurite outgrowth in mammalian neurons. Progress In Brain Research 1994, 103: 137-151. PMID: 7886202, DOI: 10.1016/s0079-6123(08)61134-6.Peer-Reviewed Original Research