Pulsatile Luteinizing Hormone Amplitude and Progesterone Metabolite Excretion Are Reduced in Obese Women
Jain A, Polotsky A, Rochester D, Berga S, Loucks T, Zeitlian G, Gibbs K, Polotsky H, Feng S, Isaac B, Santoro N. Pulsatile Luteinizing Hormone Amplitude and Progesterone Metabolite Excretion Are Reduced in Obese Women. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 2468-2473. PMID: 17440019, DOI: 10.1210/jc.2006-2274.Peer-Reviewed Original ResearchConceptsNormal-weight womenDaily hormonesObese womenLH pulsationsPregnanediol glucuronideOvarian axis functionAbnormal menstrual cyclesLH pulse frequencyBody mass indexNormal-weight controlsProgesterone metabolite excretionSeparate control groupEumenorrheic womenLH pulsesMass indexAxis functionFemale obesityMenstrual cycleObese stateProgesterone secretionProgesterone metabolitesUrine collectionMetabolite excretionFirst morningControl group