Distinct Disulfide Isomers of μ‑Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels
Khoo KK, Gupta K, Green BR, Zhang MM, Watkins M, Olivera BM, Balaram P, Yoshikami D, Bulaj G, Norton RS. Distinct Disulfide Isomers of μ‑Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels. Biochemistry 2012, 51: 9826-9835. PMID: 23167564, PMCID: PMC4131687, DOI: 10.1021/bi301256s.Peer-Reviewed Original ResearchConceptsΜ-Conotoxin KIIIADisulfide connectivityCollision-induced dissociation fragmentationDisulfide isomersNuclear magnetic resonance dataNative disulfide connectivityDisulfide patternVenom-derived peptidesDisulfide bond connectivitySame disulfide connectivityOxidative foldingDissociation fragmentationMagnetic resonance dataBond connectivityMultiple disulfide bondsMinor productsMajor isomerSolution structureActive peptidesIsomersΜ-conotoxinsResonance dataKIIIAVenom of ConusDisulfide bonds