Cyclic AMP-dependent Protein Lysine Acylation in Mycobacteria Regulates Fatty Acid and Propionate Metabolism*
Nambi S, Gupta K, Bhattacharyya M, Ramakrishnan P, Ravikumar V, Siddiqui N, Thomas AT, Visweswariah SS. Cyclic AMP-dependent Protein Lysine Acylation in Mycobacteria Regulates Fatty Acid and Propionate Metabolism*. Journal Of Biological Chemistry 2013, 288: 14114-14124. PMID: 23553634, PMCID: PMC3656268, DOI: 10.1074/jbc.m113.463992.Peer-Reviewed Original ResearchMeSH KeywordsAcetylesteraseAmino Acid SequenceBacterial ProteinsCoenzyme A LigasesCyclic AMPFatty AcidsGene DeletionGene Expression Regulation, BacterialLysineMass SpectrometryMolecular Sequence DataMutagenesisMycobacterium bovisMycobacterium tuberculosisPropionatesSequence Homology, Amino AcidSignal TransductionConceptsCAMP-dependent mannerAcyl-CoA synthetaseLysine residuesProtein Lysine AcylationLysine acetyltransferaseLysine acylationPosttranslational modificationsImportant lysine residuesFatty acidsBiological processesIntracellular cAMP levelsFADDMultiple substratesCoA synthetasePropionyl-CoAAcetylationBiological organismsRegulatory cycleCritical roleCAMP levelsResiduesBovis bacillus Calmette-GuérinPropionate metabolismMetabolismEukaryotes