2022
Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation
Hong Z, Adlakha J, Wan N, Guinn E, Giska F, Gupta K, Melia TJ, Reinisch KM. Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation. Journal Of Cell Biology 2022, 221: e202207022. PMID: 36282247, PMCID: PMC9597353, DOI: 10.1083/jcb.202207022.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumLipid dropletsProtein-mediated transferLipid transport proteinsLipid droplet formationLD biologyMitochondrial proteinsSecretory pathwayMass spectrometry analysisTerminal domainMitochondrial morphologyTransport proteinsLipid transportersCellular membranesLD metabolismMembrane contactX-ray structureSpectrometry analysisOrganellesGlycerophospholipidsProteinHydrophobic cavityFatty acidsLipidsMembrane
2013
Cyclic AMP-dependent Protein Lysine Acylation in Mycobacteria Regulates Fatty Acid and Propionate Metabolism*
Nambi S, Gupta K, Bhattacharyya M, Ramakrishnan P, Ravikumar V, Siddiqui N, Thomas AT, Visweswariah SS. Cyclic AMP-dependent Protein Lysine Acylation in Mycobacteria Regulates Fatty Acid and Propionate Metabolism*. Journal Of Biological Chemistry 2013, 288: 14114-14124. PMID: 23553634, PMCID: PMC3656268, DOI: 10.1074/jbc.m113.463992.Peer-Reviewed Original ResearchMeSH KeywordsAcetylesteraseAmino Acid SequenceBacterial ProteinsCoenzyme A LigasesCyclic AMPFatty AcidsGene DeletionGene Expression Regulation, BacterialLysineMass SpectrometryMolecular Sequence DataMutagenesisMycobacterium bovisMycobacterium tuberculosisPropionatesSequence Homology, Amino AcidSignal TransductionConceptsCAMP-dependent mannerAcyl-CoA synthetaseLysine residuesProtein Lysine AcylationLysine acetyltransferaseLysine acylationPosttranslational modificationsImportant lysine residuesFatty acidsBiological processesIntracellular cAMP levelsFADDMultiple substratesCoA synthetasePropionyl-CoAAcetylationBiological organismsRegulatory cycleCritical roleCAMP levelsResiduesBovis bacillus Calmette-GuérinPropionate metabolismMetabolismEukaryotes