2024
Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States
Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz H, Bell M, Chen K. Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2403960121. PMID: 39316057, PMCID: PMC11459178, DOI: 10.1073/pnas.2403960121.Peer-Reviewed Original ResearchConceptsWildland firesContiguous United StatesNonaccidental mortalityExposure to ambient fine particlesSmoke PM<sWildland fire smokeMoving average concentrationsAmbient fine particlesLong-term exposureAverage concentrationSmoke PMHealth risksFine particlesFire smokeTemporal confoundingHealth effectsKidney disease mortalityChronic kidney disease mortalityPublic health actionFireMortality rateUnited StatesDisease mortalityHealth actionsMortality outcomesShort-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries
Ma Y, Nobile F, Marb A, Dubrow R, Stafoggia M, Breitner S, Kinney P, Chen K. Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries. JAMA Network Open 2024, 7: e2354607. PMID: 38427355, PMCID: PMC10907920, DOI: 10.1001/jamanetworkopen.2023.54607.Peer-Reviewed Original ResearchConceptsShort-term exposure to air pollutionExposure to air pollutionFine particulate matterCross-sectional studyAir pollutionFixed-effects modelParticulate matterShort-term exposure to PM2.5Short-term exposure to fine particulate matterNO2 concentrationsExposure to fine particulate matterMortality rateNitrogen dioxideSignificant effect modificationDaily PM2.5 concentrationsTime-varying confoundersExposure to PM2.5Health outcomesEstimate associationsMortality dataEffect modificationPM2.5 concentrationsMain OutcomesDay-to-dayCentral-southern Italy
2023
Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries
Wang P, Asare E, Pitzer V, Dubrow R, Chen K. Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries. JAMA Pediatrics 2023, 177: 1206-1214. PMID: 37782513, PMCID: PMC10546297, DOI: 10.1001/jamapediatrics.2023.3964.Peer-Reviewed Original ResearchConceptsMiddle-income countriesDiarrhea riskOdds ratioMAIN OUTCOMEMixed-effects logistic regression modelRisk of diarrheaCross-sectional studyHigher odds ratioPrevalence of diarrheaLogistic regression modelsHealth survey programUnexposed childrenEffect modificationChild healthDiarrhea prevalenceSurvey clustersSignificant associationHygiene practicesFourth weekWeeksStrong associationRandom interceptYoung childrenChildrenDiarrhea
2019
Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014
Chen K, Breitner S, Wolf K, Hampel R, Meisinger C, Heier M, von Scheidt W, Kuch B, Peters A, Schneider A, Peters A, Schulz H, Schwettmann L, Leidl R, Heier M, Strauch K. Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014. European Heart Journal 2019, 40: 1600-1608. PMID: 30859207, DOI: 10.1093/eurheartj/ehz116.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMI riskCases of MIRisk of MITime-stratified case-crossover analysisPopulation susceptibilityCase-crossover analysisArea of AugsburgCoronary deathDiabetes mellitusNon-significant declineSubgroup analysisRelative riskLag non-linear modelShort-term exposureMI eventsEnvironmental triggersInfarctionRiskFuture studiesSocioeconomic settingsAssociationExposureSusceptibility
2018
Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study
Chen K, Fiore AM, Chen R, Jiang L, Jones B, Schneider A, Peters A, Bi J, Kan H, Kinney PL. Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study. PLOS Medicine 2018, 15: e1002598. PMID: 29969446, PMCID: PMC6029756, DOI: 10.1371/journal.pmed.1002598.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge FactorsAgedAir PollutantsCardiovascular DiseasesCause of DeathChildChild, PreschoolChinaClimate ChangeEnvironmental MonitoringFemaleHealth StatusHumansInfantInfant, NewbornInhalation ExposureMaleMiddle AgedModels, TheoreticalOzonePopulation DynamicsPrognosisRespiratory Tract DiseasesRisk AssessmentRisk FactorsSeasonsTime FactorsUrban HealthVehicle EmissionsYoung AdultConceptsGlobal chemistry-climate modelChemistry-climate modelOzone-related mortalityRepresentative Concentration PathwaysEmission scenariosHigh global warmingGlobal warmingClimate changeChange scenariosOzone pollutionClimate Change (IPCC) Representative Concentration PathwaysEmission scenario RCP8.5Emission scenarios RCP4.5Future ozone projectionsStatistical downscaling approachModerate global warmingOzone precursor emissionsFine spatial resolutionSpatial resolutionHigh ambient ozoneOzone projectionsOzone changesOzone observationsScenario RCP8.5Change projections
2014
Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China
Chen K, Bi J, Chen J, Chen X, Huang L, Zhou L. Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China. The Science Of The Total Environment 2014, 506: 18-25. PMID: 25460935, DOI: 10.1016/j.scitotenv.2014.10.092.Peer-Reviewed Original ResearchConceptsDifferent heat wave definitionsDisease mortalityChronic obstructive pulmonary disease (COPD) mortalityIschemic heart disease mortalityLag day 2Heart disease mortalityBurden of diseaseCause-specific mortalityDaily mortalityCardiovascular mortalityStroke mortalityEffect modificationHeat wave definitionsStratified analysisRespiratory mortalityDay 2Total mortalityMortalityConsecutive daysHeat warning systemsLower educationDaysAssociationGood model fitCritical role