2023
Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States
Ma Y, Zang E, Opara I, Lu Y, Krumholz H, Chen K. Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States. Nature Human Behaviour 2023, 7: 2074-2083. PMID: 37653149, PMCID: PMC10901568, DOI: 10.1038/s41562-023-01694-7.Peer-Reviewed Original ResearchMeSH KeywordsBlack or African AmericanCardiovascular DiseasesEthnicityHispanic or LatinoHumansParticulate MatterRacial GroupsUnited StatesWhiteConceptsNon-Hispanic White peopleCVD deathMortality burdenNon-Hispanic black peopleCardiovascular disease mortality ratesDisease mortality ratesNon-Hispanic blacksRace/ethnicityMortality rateLong-term exposureWhite peopleEthnic disparitiesHealth benefitsHispanic peopleSignificant differencesBurdenDeathUS countiesEthnic groupsAbsolute disparityAssociationExposureEthnic minoritiesDisparitiesAmbient fine particulate matter (PM2.5) concentrations
2022
Future temperature-related mortality considering physiological and socioeconomic adaptation: a modelling framework
Rai M, Breitner S, Wolf K, Peters A, Schneider A, Chen K. Future temperature-related mortality considering physiological and socioeconomic adaptation: a modelling framework. The Lancet Planetary Health 2022, 6: e784-e792. PMID: 36208641, DOI: 10.1016/s2542-5196(22)00195-4.Peer-Reviewed Original Research
2021
Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities
Chen K, Breitner S, Wolf K, Stafoggia M, Sera F, Vicedo-Cabrera AM, Guo Y, Tong S, Lavigne E, Matus P, Valdés N, Kan H, Jaakkola JJK, Ryti NRI, Huber V, Scortichini M, Hashizume M, Honda Y, Nunes B, Madureira J, Holobâcă IH, Fratianni S, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli MS, Guo YL, Chen BY, Li S, Milojevic A, Zanobetti A, Schwartz J, Bell ML, Gasparrini A, Schneider A. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities. The Lancet Planetary Health 2021, 5: e191-e199. PMID: 33838734, DOI: 10.1016/s2542-5196(21)00026-7.Peer-Reviewed Original ResearchConceptsExposure-response curvesAmbient carbon monoxideTotal mortalityDaily mortalityUK Medical Research CouncilElevated mortality riskLarge epidemiological investigationsPotential publication biasMedical Research CouncilCity-specific associationsMeta-analytical modelsShort-term associationsQuasi-Poisson distributionCurrent air quality guidelinesEpidemiological evidenceMortality riskDaily total mortalityShort-term exposurePublication biasSignificant associationEpidemiological investigationsTime-series studyGreater riskMortalityMortality data
2018
Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study
Chen K, Fiore AM, Chen R, Jiang L, Jones B, Schneider A, Peters A, Bi J, Kan H, Kinney PL. Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study. PLOS Medicine 2018, 15: e1002598. PMID: 29969446, PMCID: PMC6029756, DOI: 10.1371/journal.pmed.1002598.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge FactorsAgedAir PollutantsCardiovascular DiseasesCause of DeathChildChild, PreschoolChinaClimate ChangeEnvironmental MonitoringFemaleHealth StatusHumansInfantInfant, NewbornInhalation ExposureMaleMiddle AgedModels, TheoreticalOzonePopulation DynamicsPrognosisRespiratory Tract DiseasesRisk AssessmentRisk FactorsSeasonsTime FactorsUrban HealthVehicle EmissionsYoung AdultConceptsGlobal chemistry-climate modelChemistry-climate modelOzone-related mortalityRepresentative Concentration PathwaysEmission scenariosHigh global warmingGlobal warmingClimate changeChange scenariosOzone pollutionClimate Change (IPCC) Representative Concentration PathwaysEmission scenario RCP8.5Emission scenarios RCP4.5Future ozone projectionsStatistical downscaling approachModerate global warmingOzone precursor emissionsFine spatial resolutionSpatial resolutionHigh ambient ozoneOzone projectionsOzone changesOzone observationsScenario RCP8.5Change projectionsTwo-way effect modifications of air pollution and air temperature on total natural and cardiovascular mortality in eight European urban areas
Chen K, Wolf K, Breitner S, Gasparrini A, Stafoggia M, Samoli E, Andersen ZJ, Bero-Bedada G, Bellander T, Hennig F, Jacquemin B, Pekkanen J, Hampel R, Cyrys J, Peters A, Schneider A, Group U. Two-way effect modifications of air pollution and air temperature on total natural and cardiovascular mortality in eight European urban areas. Environment International 2018, 116: 186-196. PMID: 29689465, DOI: 10.1016/j.envint.2018.04.021.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionCardiovascular DiseasesCitiesEuropeHumansParticulate MatterRetrospective StudiesTemperatureConceptsCardiovascular mortalityAmbient air pollutionShort-term associationsTemperature-mortality associationCity-specific effect estimatesEffect modificationHigh air pollutionMortality riskEpidemiological studiesInfluenza epidemicsMortalityEffect estimatesMortality effectsAir pollutionDaily mortalityAssociationDaysAir pollution levelsDistributed lag
2017
Impact of climate change on heat-related mortality in Jiangsu Province, China
Chen K, Horton RM, Bader DA, Lesk C, Jiang L, Jones B, Zhou L, Chen X, Bi J, Kinney PL. Impact of climate change on heat-related mortality in Jiangsu Province, China. Environmental Pollution 2017, 224: 317-325. PMID: 28237309, PMCID: PMC5387110, DOI: 10.1016/j.envpol.2017.02.011.Peer-Reviewed Original ResearchMeSH KeywordsAcclimatizationCardiovascular DiseasesChinaClimate ChangeHot TemperatureHumansModels, TheoreticalPopulation DensityPublic HealthRespiratory Tract DiseasesConceptsCause-specific mortalityChronic obstructive pulmonary diseaseIschemic heart diseaseSpecific public health interventionsObstructive pulmonary diseaseCause of deathPublic health interventionsHeat-related mortalityPulmonary diseaseHeart diseaseHealth burdenExposure-response functionsGlobal-scale General Circulation ModelsHealth interventionsTotal mortalityNonurban residentsMortalityRural countiesDiseaseNonurban areasFuture heat-related mortalityLittle evidenceMortality estimationHigh heat-related mortalityStroke
2016
Urbanization Level and Vulnerability to Heat-Related Mortality in Jiangsu Province, China
Chen K, Zhou L, Chen X, Ma Z, Liu Y, Huang L, Bi J, Kinney PL. Urbanization Level and Vulnerability to Heat-Related Mortality in Jiangsu Province, China. Environmental Health Perspectives 2016, 124: 1863-1869. PMID: 27152420, PMCID: PMC5132638, DOI: 10.1289/ehp204.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesChinaHot TemperatureHumansModels, TheoreticalRespiratory Tract DiseasesUrban PopulationUrbanizationConceptsMortality risk
2014
Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China
Chen K, Bi J, Chen J, Chen X, Huang L, Zhou L. Influence of heat wave definitions to the added effect of heat waves on daily mortality in Nanjing, China. The Science Of The Total Environment 2014, 506: 18-25. PMID: 25460935, DOI: 10.1016/j.scitotenv.2014.10.092.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAir PollutionCardiovascular DiseasesChinaEnvironmental ExposureFemaleHot TemperatureHumansMaleMortalityRespiratory Tract DiseasesConceptsDifferent heat wave definitionsDisease mortalityChronic obstructive pulmonary disease (COPD) mortalityIschemic heart disease mortalityLag day 2Heart disease mortalityBurden of diseaseCause-specific mortalityDaily mortalityCardiovascular mortalityStroke mortalityEffect modificationHeat wave definitionsStratified analysisRespiratory mortalityDay 2Total mortalityMortalityConsecutive daysHeat warning systemsLower educationDaysAssociationGood model fitCritical role