Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins
Seabrook L, Franco C, Loy C, Osman J, Fredlender C, Zimak J, Campos M, Nguyen S, Watson R, Levine S, Khalil M, Sumigray K, Trader D, Albrecht L. Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. Nature Chemical Biology 2024, 1-11. PMID: 39414979, DOI: 10.1038/s41589-024-01741-y.Peer-Reviewed Original ResearchProtein arginine methyltransferasesTarget proteinsLoss-of-function phenotypesDegradation of intracellular proteinsUbiquitin-proteasome pathwayHistone deacetylase 6Bromodomain-containing protein 4Discovery of small moleculesTargeted protein degradationDegrade target proteinsTargeting chimerasArginine methylationArginine methyltransferasesProtein methylationPathogenic proteinsLysosomal deliveryLysosomal pathwayIntracellular proteinsLysosomal degradationHeterobifunctional small moleculesProtein degradationSmall-molecule degradersLysosomal proteolysisSubstrate degradationSmall molecules