2023
Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure
Wong S, Lebois L, Ely T, van Rooij S, Bruce S, Murty V, Jovanovic T, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Stevens J, Harnett N. Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure. Molecular Psychiatry 2023, 28: 5140-5149. PMID: 36932158, PMCID: PMC10505244, DOI: 10.1038/s41380-023-02012-3.Peer-Reviewed Original ResearchInternal capsuleDiffusion tensor imagingPosttraumatic dysfunctionWhite matter microstructureFractional anisotropyPTSD symptomsChildhood traumaRecent traumaChildhood maltreatmentTrauma exposureBilateral internal capsuleFuture PTSD symptomsAdulthood trauma exposureChildhood trauma exposureStress-related disordersWhite matter tractsPCL-5 scoresAssessment of PTSDSensory fibersEmergency departmentRisk factorsCorpus callosumNeural pathwaysCingulum bundleNeural circuitsPrior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study
Rowland G, Roeckner A, Ely T, Lebois L, van Rooij S, Bruce S, Jovanovic T, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Gentile N, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Stevens J, Harnett N. Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study. Biological Psychiatry Global Open Science 2023, 3: 705-715. PMID: 37881578, PMCID: PMC10593890, DOI: 10.1016/j.bpsgos.2023.02.004.Peer-Reviewed Original ResearchPrior sexual traumaPosttraumatic dysfunctionAcute trauma exposureLifetime trauma loadTrauma exposureSexual traumaTrauma loadNeural circuitryVisual cortex connectivitySexual trauma exposureTraumatic eventsMagnetic resonance imagingUnderlying neurobiological mechanismsPosttraumatic stress disorderPrevious sexual traumaRecent traumatic eventsEmergency departmentCortex connectivityAcute aftermathVisual processing regionsLeft amygdalaPosttraumatic depressionSubsequent traumatic eventsResonance imagingConnectivity differences
2022
Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma
Harnett N, Dumornay N, Delity M, Sanchez L, Mohiuddin K, Musey P, Seamon M, McLean S, Kessler R, Koenen K, Beaudoin F, Lebois L, van Rooij S, Sampson N, Michopoulos V, Maples-Keller J, Haran J, Storrow A, Lewandowski C, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, McGrath M, Hudak L, Pascual J, House S, An X, Stevens J, Neylan T, Jovanovic T, Linnstaedt S, Germine L, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O'Neil B, Sergot P, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Smoller J, Luna B, Harte S, Elliott J, Ressler K. Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma. Psychological Medicine 2022, 53: 2553-2562. PMID: 35094717, PMCID: PMC9339026, DOI: 10.1017/s0033291721004475.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPrevious trauma exposureTrauma exposurePosttraumatic depressionPrior differencesChildhood emotional abusePrior trauma exposureSelf-report assessmentsWhite participantsPosttraumatic stressStress disorderAnxiety symptomsEmotional abuseLife stressorsPTSD ratesEarly aftermathPosttraumatic dysfunctionAnxietySymptom trajectoriesRecent traumaEthnic differencesAURORA studyParticipantsSymptom recoveryRecent research