2024
Association of HRS-AKI with Mortality in Patients with Cirrhosis Requiring Renal Replacement Therapy: Results from the HRS-HARMONY Consortium.
Cama-Olivares A, Ouyang T, Takeuchi T, St Hillien S, Robinson J, Chung R, Cullaro G, Karvellas C, Levitsky J, Orman E, Patidar K, Regner K, Saly D, Sawinski D, Sharma P, Teixeira J, Ufere N, Velez J, Wadei H, Wahid N, Allegretti A, Neyra J, Belcher J. Association of HRS-AKI with Mortality in Patients with Cirrhosis Requiring Renal Replacement Therapy: Results from the HRS-HARMONY Consortium. Kidney360 2024 PMID: 39348201, DOI: 10.34067/kid.0000000589.Peer-Reviewed Original ResearchEtiology of AKIHRS-AKIAKI-RRTRenal replacement therapyContinuous RRTIntermittent hemodialysisAdult patientsHospitalized patientsAKI etiologyReplacement therapyAssociated with increased 90-day mortalityMulticenter retrospective cohort studyNon-HRS-AKIAssociated with increased mortalityConsecutive adult patientsRetrospective cohort studyHospital network systemHepatorenal syndromeContemporary cohortInpatient populationMechanical ventilationRRT modalityCohort studyClinical variablesPrimary outcomeImpact of acute kidney injury response on survival and liver transplant rates in hospitalized patients with cirrhosis awaiting liver transplantation: Results from the HRS-HARMONY consortium.
Li X, Ouyang T, Belcher J, Patidar K, Cullaro G, Asrani S, Wadei H, Simonetto D, Regner K, Dageforde L, Przybyszewski E, Wilechansky R, Sharma P, Ufere N, Duarte-Rojo A, Wahid N, Orman E, St Hillien S, Robinson J, Chung R, Allegretti A. Impact of acute kidney injury response on survival and liver transplant rates in hospitalized patients with cirrhosis awaiting liver transplantation: Results from the HRS-HARMONY consortium. Liver Transplantation 2024 PMID: 39073567, DOI: 10.1097/lvt.0000000000000445.Peer-Reviewed Original ResearchAKI responseAcute kidney injuryTransplant-free survivalLiver transplantationLT ratesCirrhosis patientsNon-respondersTime of liver transplantationCourse of hospitalized patientsNo responseRetrospective multicenter studyMELD-Na scoreResponse to therapyResponse to treatmentLiver transplant ratesRate of LTOverall survivalMulticenter studyKidney injuryCirrhosis etiologyCirrhosisHospitalized patientsTransplantationPatientsInjury responseOutcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium
T. A, Allegretti A, Cullaro G, Ouyang T, Asrani S, Chung R, Przybyszewski E, Wilechansky R, Robinson J, Sharma P, Simonetto D, Jalal P, Orman E, Wadei H, St. Hillien S, Saly D, Ufere N, Dageforde L, Regner K, Belcher J, Patidar K, Consortium F. Outcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium. Alimentary Pharmacology & Therapeutics 2024, 60: 778-786. PMID: 39010302, PMCID: PMC11349455, DOI: 10.1111/apt.18159.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAcute kidney injuryAcute kidney injury phenotypesHepatorenal syndromeMELD-NaDevelopment of acute kidney injuryCumulative incidence of deathConsecutive adult patientsOutcomes of patientsAlcohol Abuse and Alcoholism (NIAAANon-AH groupRenal replacement therapyPresence of AHAcute tubular necrosisRetrospective cohort studyPredictors of mortalityIncidence of deathAKI stageClinical courseReplacement therapyAdult patientsKidney injuryCumulative incidencePoor prognosisTubular necrosisUse of Terlipressin in AKI Associated with Hepatorenal Syndrome: PRO
Belcher J. Use of Terlipressin in AKI Associated with Hepatorenal Syndrome: PRO. Kidney360 2024, 5: 791-794. PMID: 38526157, PMCID: PMC11219105, DOI: 10.34067/kid.0000000000000341.Peer-Reviewed Original ResearchAcute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting
Nadim M, Kellum J, Forni L, Francoz C, Asrani S, Ostermann M, Allegretti A, Neyra J, Olson J, Piano S, VanWagner L, Verna E, Akcan-Arikan A, Angeli P, Belcher J, Biggins S, Deep A, Garcia-Tsao G, Genyk Y, Gines P, Kamath P, Kane-Gill S, Kaushik M, Lumlertgul N, Macedo E, Maiwall R, Marciano S, Pichler R, Ronco C, Tandon P, Velez J, Mehta R, Durand F. Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting. Journal Of Hepatology 2024, 81: 163-183. PMID: 38527522, PMCID: PMC11193657, DOI: 10.1016/j.jhep.2024.03.031.Peer-Reviewed Original ResearchAcute Disease Quality InitiativeInternational Club of AscitesAcute kidney injuryHRS-AKIQuality InitiativeHepatorenal syndromePost-discharge follow-upKidney injuryMultidisciplinary consensus meetingRisk of progression to chronic kidney diseaseProgression to chronic kidney diseasePhenotypes of acute kidney injuryFollow-up of patientsBridge to liver transplantationIncreased in-hospital morbidityIn-hospital morbidityPost-discharge follow-up of patientsChronic kidney diseaseMortality riskConsensus meetingInternational ClubCurative optionSplanchnic vasoconstrictorsAdvanced cirrhosisLiver transplantationHepatorenal Syndrome Type 1: Diagnosis and Treatment
Belcher J. Hepatorenal Syndrome Type 1: Diagnosis and Treatment. Advances In Kidney Disease And Health 2024, 31: 100-110. PMID: 38649214, DOI: 10.1053/j.akdh.2023.05.001.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHepatorenal syndromeKidney injuryFunctional acute kidney injuryUrinary biomarkers of kidney injuryAssociated with significant morbidityFractional excretion of sodiumNeutrophil gelatinase-associated lipocalinDiagnostic criteriaBiomarkers of kidney injuryMultiple urinary biomarkersOptimal dosing strategiesExcretion of sodiumPoint-of-care ultrasoundAccurate differential diagnosisAnalog of vasopressinSets of diagnostic criteriaAdvanced cirrhosisAlbumin administrationSignificant morbidityVolume resuscitationTherapeutic optionsDosing strategiesFractional excretionDifferential diagnosis
2023
Outcomes of AKI on CKD in Hospitalized Cirrhotic Patients: Data from the HRS-HARMONY Consortium
St. Hillien S, Belcher J, Ouyang T, Robinson J, Regner K, Velez J, Patidar K, Cullaro G, Chung R, Allegretti A. Outcomes of AKI on CKD in Hospitalized Cirrhotic Patients: Data from the HRS-HARMONY Consortium. Journal Of The American Society Of Nephrology 2023, 34: 104-104. DOI: 10.1681/asn.20233411s1104b.Peer-Reviewed Original ResearchAssociation of AKI-Hepatorenal Syndrome (HRS) with Mortality in Hospitalized Cirrhotic Patients Requiring Renal Replacement Therapy: Results from the HRS-HARMONY Consortium
Cama-Olivares A, Ouyang T, Takeuchi T, St. Hillien S, Robinson J, Patidar K, Cullaro G, Chung R, Regner K, Velez J, Wahid N, Sharma P, Allegretti A, Neyra J, Belcher J. Association of AKI-Hepatorenal Syndrome (HRS) with Mortality in Hospitalized Cirrhotic Patients Requiring Renal Replacement Therapy: Results from the HRS-HARMONY Consortium. Journal Of The American Society Of Nephrology 2023, 34: 103-104. DOI: 10.1681/asn.20233411s1103c.Peer-Reviewed Original ResearchThe prognostic implications of early-stage AKI: Defining the threshold for concern
Winters A, Belcher J. The prognostic implications of early-stage AKI: Defining the threshold for concern. Liver Transplantation 2023, 30: 235-236. PMID: 37903066, DOI: 10.1097/lvt.0000000000000292.Peer-Reviewed Original ResearchGood Enough? Terlipressin, Hepatorenal Syndrome, and the Usage of RRT
Belcher J. Good Enough? Terlipressin, Hepatorenal Syndrome, and the Usage of RRT. Kidney360 2023, 4: 1011-1013. PMID: 37651662, PMCID: PMC10484352, DOI: 10.34067/kid.0000000000000217.Peer-Reviewed Original ResearchIncidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US
Patidar K, Belcher J, Regner K, St. Hillien S, Simonetto D, Asrani S, Neyra J, Sharma P, Velez J, Wadei H, Nadim M, Chung R, Seethapathy R, Parada X, Ouyang T, Ufere N, Robinson J, Diaz P, Wilechansky R, Przybyszewski E, Smith T, Ali A, Orman E, Schulz P, Siddiqui S, Shabbir R, Liu L, Cama-Olivares A, Flannery A, Baker M, Gunasekaran D, Aswine A, Issa R, Li J, Verma S, Chalmers D, Varghese V, Lam W, Mohamed M, Kovacic R, Gaddy A, Attieh R, Cortes P, Semnani S, Wang L, Khemichian S, Allegretti A, consortium F. Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US. Journal Of Hepatology 2023, 79: 1408-1417. PMID: 37517455, PMCID: PMC10807505, DOI: 10.1016/j.jhep.2023.07.010.Peer-Reviewed Original ResearchConceptsEtiology of AKIHRS-AKISubdistribution hazard ratiosHepatorenal syndromePrerenal AKIKidney injuryHigh morbidityIncidence ratePractice patternsSimilar outcomesHigher AKI stageAcute kidney injuryRetrospective cohort studyAcute tubular necrosisConsecutive adult patientsEtiology of injuryAKI stageAKI definitionLiver transplantAdult patientsCohort studyHazard ratioSevere complicationsTubular necrosisComplete responseHepatorenal Syndrome Pathophysiology, Diagnosis, and Treatment
Belcher J. Hepatorenal Syndrome Pathophysiology, Diagnosis, and Treatment. Medical Clinics Of North America 2023, 107: 781-792. PMID: 37258014, DOI: 10.1016/j.mcna.2023.03.009.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHepatorenal syndromeCombination of midodrineFirst-line standardPooling of bloodAnalog of vasopressinIntravenous albuminKidney injuryLiver transplantationVasoconstrictor agentsDefinitive treatmentPathophysiologic cascadeSplanchnic systemSyndrome pathophysiologyArterial volumeTreatmentTerlipressinCirrhosisMidodrineOctreotidePatientsTransplantationPathophysiologySyndromeInjuryRecent Advances in the Management of Hepatorenal Syndrome: A US Perspective
Patidar K, Piano S, Cullaro G, Belcher J, Allegretti A, Consortia H. Recent Advances in the Management of Hepatorenal Syndrome: A US Perspective. Clinical Gastroenterology And Hepatology 2023, 21: 897-901.e1. PMID: 36801201, PMCID: PMC10038893, DOI: 10.1016/j.cgh.2022.12.034.Peer-Reviewed Original ResearchResponsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1
Velez J, Karakala N, Tayebi K, Wickman T, Mohamed M, Kovacic R, Therapondos G, Kanduri S, Allegretti A, Belcher J, Regner K, Wentowski C. Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1. Kidney360 2023, 4: e448-e456. PMID: 36763632, PMCID: PMC10278824, DOI: 10.34067/kid.0000000000000068.Peer-Reviewed Original ResearchConceptsHepatorenal syndrome type 1Mean arterial pressureSyndrome type 1HRS-1Baseline SCrMAP riseType 1Serum creatinineArterial pressureKidney functionDay 14Baseline mean arterial pressureMean mean arterial pressureMedian mean arterial pressureEnd-stage liver diseaseMultivariate logistic regression analysisFavorable renal outcomeOptimal MAP targetsUse of norepinephrineLogistic regression analysisGreater reductionMedian sCrNorepinephrine useVasoconstrictor therapyRenal outcomes
2022
Towards a Better Crystal Ball: Urinary C-C Motif Chemokine Ligand 14 (CCL14) and Persistent Severe AKI
Belcher JM. Towards a Better Crystal Ball: Urinary C-C Motif Chemokine Ligand 14 (CCL14) and Persistent Severe AKI. Kidney360 2022, 3: 1124-1127. PMID: 35919534, PMCID: PMC9337887, DOI: 10.34067/kid.0002162022.Peer-Reviewed Original ResearchBile Acids Are Important Contributors to AKI Associated with Liver Disease: CON
Allegretti AS, Belcher JM. Bile Acids Are Important Contributors to AKI Associated with Liver Disease: CON. Kidney360 2022, 3: 21-24. PMID: 35378020, PMCID: PMC8967622, DOI: 10.34067/kid.0006512020.Peer-Reviewed Original Research
2021
Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward
Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS, Investigators H. Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward. American Journal Of Kidney Diseases 2021, 79: 737-745. PMID: 34606933, DOI: 10.1053/j.ajkd.2021.08.016.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHepatorenal syndromeRespiratory adverse eventsPrimary end pointFirst-line therapyMean arterial pressureSympathetic nervous systemSynthetic vasopressin analogueAdvanced cirrhosisHRS reversalAldosterone systemKidney injuryLack of evidenceAdverse eventsMortality benefitPortal pressureArterial pressureFulminant formSplanchnic systemSignificant morbidityRenal vasculatureVasodilatory substancesApparent increased rateTerlipressinCONFIRM trialsUrinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St. Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clinical And Translational Gastroenterology 2021, 12: e00359. PMID: 33979307, PMCID: PMC8116001, DOI: 10.14309/ctg.0000000000000359.Peer-Reviewed Original ResearchConceptsNeutrophil gelatinase-associated lipocalinUrinary neutrophil gelatinase-associated lipocalinAcute kidney injuryAcute tubular necrosisPrerenal acute kidney injuryHepatorenal syndromeKidney injuryC-statisticManagement of AKITypes of AKIEnd-stage liver disease (MELD) scoreTransplant-free survivalLiver Disease scoreMedian serum creatinineGelatinase-associated lipocalinPrediction of mortalityNet reclassification indexDiscrimination incrementProspective cohortSerum creatinineTubular necrosisProspective studyReclassification indexUnadjusted analysesPrognostic marker
2020
The Role of Telenephrology in the Management of CKD.
Belcher JM. The Role of Telenephrology in the Management of CKD. Kidney360 2020, 1: 1310-1315. PMID: 35372872, PMCID: PMC8815503, DOI: 10.34067/kid.0000802019.Peer-Reviewed Original Research
2019
47 Acute Kidney Injury Diagnostics and Biomarkers
Belcher J, Parikh C. 47 Acute Kidney Injury Diagnostics and Biomarkers. 2019, 713-724.e5. DOI: 10.1016/b978-0-323-52978-5.00047-1.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryUrine outputPrognosis of AKICommon clinical conditionLong-term outcomesAppropriate clinical trialsPotential therapeutic efficacyNew therapeutic approachesMultiple potential therapiesFrank injurySerum creatinineAcute settingInjury biomarkersHigh morbidityClinical trialsDifferential diagnosisClinical conditionsEarly diagnosisTherapeutic approachesPotential therapyAnimal modelsPromising biomarkerSuch biomarkersTherapeutic efficacy