2023
Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1
Velez J, Karakala N, Tayebi K, Wickman T, Mohamed M, Kovacic R, Therapondos G, Kanduri S, Allegretti A, Belcher J, Regner K, Wentowski C. Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1. Kidney360 2023, 4: e448-e456. PMID: 36763632, PMCID: PMC10278824, DOI: 10.34067/kid.0000000000000068.Peer-Reviewed Original ResearchConceptsHepatorenal syndrome type 1Mean arterial pressureSyndrome type 1HRS-1Baseline SCrMAP riseType 1Serum creatinineArterial pressureKidney functionDay 14Baseline mean arterial pressureMean mean arterial pressureMedian mean arterial pressureEnd-stage liver diseaseMultivariate logistic regression analysisFavorable renal outcomeOptimal MAP targetsUse of norepinephrineLogistic regression analysisGreater reductionMedian sCrNorepinephrine useVasoconstrictor therapyRenal outcomes
2021
Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St. Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT. Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. Clinical And Translational Gastroenterology 2021, 12: e00359. PMID: 33979307, PMCID: PMC8116001, DOI: 10.14309/ctg.0000000000000359.Peer-Reviewed Original ResearchConceptsNeutrophil gelatinase-associated lipocalinUrinary neutrophil gelatinase-associated lipocalinAcute kidney injuryAcute tubular necrosisPrerenal acute kidney injuryHepatorenal syndromeKidney injuryC-statisticManagement of AKITypes of AKIEnd-stage liver disease (MELD) scoreTransplant-free survivalLiver Disease scoreMedian serum creatinineGelatinase-associated lipocalinPrediction of mortalityNet reclassification indexDiscrimination incrementProspective cohortSerum creatinineTubular necrosisProspective studyReclassification indexUnadjusted analysesPrognostic marker
2019
47 Acute Kidney Injury Diagnostics and Biomarkers
Belcher J, Parikh C. 47 Acute Kidney Injury Diagnostics and Biomarkers. 2019, 713-724.e5. DOI: 10.1016/b978-0-323-52978-5.00047-1.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryUrine outputPrognosis of AKICommon clinical conditionLong-term outcomesAppropriate clinical trialsPotential therapeutic efficacyNew therapeutic approachesMultiple potential therapiesFrank injurySerum creatinineAcute settingInjury biomarkersHigh morbidityClinical trialsDifferential diagnosisClinical conditionsEarly diagnosisTherapeutic approachesPotential therapyAnimal modelsPromising biomarkerSuch biomarkersTherapeutic efficacy
2015
Creatinine Change on Vasoconstrictors as Mortality Surrogate in Hepatorenal Syndrome: Systematic Review & Meta-Analysis
Belcher JM, Coca SG, Parikh CR. Creatinine Change on Vasoconstrictors as Mortality Surrogate in Hepatorenal Syndrome: Systematic Review & Meta-Analysis. PLOS ONE 2015, 10: e0135625. PMID: 26295585, PMCID: PMC4546623, DOI: 10.1371/journal.pone.0135625.Peer-Reviewed Original ResearchConceptsDelta creatinineHepatorenal syndromeRelative riskSerum creatininePost-treatment mortalityVasoconstrictor therapyRandomized trialsHRS type 1Completion of treatmentWeb of ScienceRenal functionCreatinine changesOverall mortalitySevere complicationsControl armTreatment periodVasoconstrictor medicationCreatinineElectronic databasesMeta-AnalysisSystematic reviewMortalityType 1PatientsSignificant mortality
2014
Quantitative proteomics identification of potential protein biomarkers of early recovery after kidney transplant (591.5)
Williams K, Colangelo C, Stone K, Chung L, Abbott T, Belcher J, Marlier A, Cantley L, Parikh C. Quantitative proteomics identification of potential protein biomarkers of early recovery after kidney transplant (591.5). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.591.5.Peer-Reviewed Original ResearchKidney transplantUrine proteomeKidney transplant recipientsPotential urine biomarkersKidney transplant patientsDeceased donor kidneysDGF patientsGraft functionTransplant patientsTransplant recipientsSerum creatinineDonor kidneysUrine biomarkersUrine proteinEarly biomarkersEarly recoveryMass spectrometric-based approachesPotential protein biomarkersFirst weekIGFUrine samplesBiomarkersPatientsTransplantDGFEarly Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury
Belcher JM, Sanyal AJ, Garcia-Tsao G, Ansari N, Coca SG, Shlipak MG, Parikh CR. Early Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury. International Journal Of Nephrology 2014, 2014: 708585. PMID: 24757564, PMCID: PMC3976933, DOI: 10.1155/2014/708585.Peer-Reviewed Original ResearchAcute kidney injuryKidney injuryGlomerular filtrationCystatin CCourse of AKIOnset of AKIProgression of AKIProspective multicenter studyEventual dialysisRenal dysfunctionSerum creatinineSevere complicationsComposite endpointPrimary outcomeMulticenter studyAdverse outcomesMore rapid identificationCystatin levelsWeight cysteine proteinase inhibitorCirrhosisCreatininePatientsMultivariate analysisAccurate markerReference group