Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients
Shin JJ, Catanzaro J, Yonkof JR, Delmonte O, Sacco K, Shin MS, Reddy S, Whittington PJ, Soffer G, Mustillo PJ, Sullivan KE, Notarangelo LD, Abraham RS, Romberg N, Kang I. Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients. Journal Of Clinical Immunology 2021, 41: 795-806. PMID: 33495902, PMCID: PMC8329305, DOI: 10.1007/s10875-021-00968-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBiomarkersCase-Control StudiesCD40 LigandCD8-Positive T-LymphocytesCellular SenescenceChild, PreschoolGenes, X-LinkedGenetic Association StudiesGenetic Predisposition to DiseaseHumansImmune System DiseasesImmunophenotypingInfectionsPedigreePhenotypePrognosisReceptors, Antigen, T-CellYoung AdultConceptsT cell senescenceCD40L-deficient patientsImmunoglobulin G replacementHealthy controlsT cellsInfectious complicationsCD40L deficiencyT-cell receptor excision circle analysisPneumocystis jirovecii pneumonia prophylaxisCMV-specific proliferationPatient group 2Effector memory CD8Effective prophylactic strategyCytokine release assaysAdult healthy controlsEarly CD8Pneumonia prophylaxisProphylaxis adherenceResultsThree patientsProphylactic antibioticsSenescence-associated moleculesMemory CD8Childhood pneumoniaInfectious exposureRecurrent infections