The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis
Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S, Haber DA. The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes & Development 2013, 27: 2543-2548. PMID: 24298054, PMCID: PMC3861668, DOI: 10.1101/gad.224170.113.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor 2Loss of imprintingUntranslated regionFunctional positive feedback loopRNA helicase DHX9IGF2 mRNAAdditional regulatory mechanismsIntronic miRNANuclear poolHost genesEctopic expressionMicroRNA screenPositive feedback loopIGF2 transcriptionPrimary Wilms tumorsFetal promotersIGF2 transcriptsPromoter contributesRegulatory mechanismsIGF2 geneGrowth factor 2IGF2 expressionTranscriptionGenesMiR-483