C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells
Di Stefano B, Sardina JL, van Oevelen C, Collombet S, Kallin EM, Vicent GP, Lu J, Thieffry D, Beato M, Graf T. C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature 2013, 506: 235-239. PMID: 24336202, DOI: 10.1038/nature12885.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCCAAT-Enhancer-Binding Protein-alphaCell TransdifferentiationCells, CulturedCellular ReprogrammingChromatinCytosineDeoxyribonuclease IDioxygenasesDNA MethylationDNA-Binding ProteinsEpithelial-Mesenchymal TransitionInduced Pluripotent Stem CellsKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceOctamer Transcription Factor-3Proto-Oncogene ProteinsProto-Oncogene Proteins c-mycSOXB1 Transcription FactorsUp-RegulationConceptsInduced pluripotent stem cellsPluripotent stem cellsTranscription factors Oct4Stem cellsTET2 enzymeChromatin accessibilityPluripotency genesRapid reprogrammingEfficient reprogrammingFactors OCT4B cell precursorsReprogrammingCell precursorsCellsB cellsGenesKLF4MYCSOX2OverexpressionEnzymeExpressionActivation