2018
ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates
Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates. Journal Of Experimental Medicine 2018, 215: 1153-1168. PMID: 29449309, PMCID: PMC5881466, DOI: 10.1084/jem.20171352.Peer-Reviewed Original ResearchConceptsT cellsMemory CD8T cell fateMemory T cell survivalLong-term immunityT cell formationT cell survivalMiR-200 family membersGrowth factor βFamily membersTranscription factor ZEB1Effector CD8MiR-200 familyCD8Mesenchymal transitionReciprocal expression patternCell fateZEB1ZEB2Factor βCell survivalTGFCell formationUnknown genetic pathwaysCell fate decisions
2012
An In Vivo Functional Screen Uncovers miR-150-Mediated Regulation of Hematopoietic Injury Response
Adams BD, Guo S, Bai H, Guo Y, Megyola CM, Cheng J, Heydari K, Xiao C, Reddy EP, Lu J. An In Vivo Functional Screen Uncovers miR-150-Mediated Regulation of Hematopoietic Injury Response. Cell Reports 2012, 2: 1048-1060. PMID: 23084747, PMCID: PMC3487471, DOI: 10.1016/j.celrep.2012.09.014.Peer-Reviewed Original ResearchConceptsMiR-150Injury responseBone marrow transplant modelCareful clinical managementHematopoietic suppressionTransplant modelPeripheral bloodHematopoietic recoveryRecipient miceClinical managementAssociated impairmentRole of microRNAsMyeloid cellsHeterozygous knockoutProgenitor cellsClonogenic potentialMajor blood lineagesNormal tissue physiologyHematopoietic stemTissue physiologyC-MybTreatmentMicroRNAsFunction screenCells
2009
microRNA Expression during Trophectoderm Specification
Viswanathan SR, Mermel CH, Lu J, Lu CW, Golub TR, Daley GQ. microRNA Expression during Trophectoderm Specification. PLOS ONE 2009, 4: e6143. PMID: 19582159, PMCID: PMC2702083, DOI: 10.1371/journal.pone.0006143.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlastocystCell DifferentiationCell LineageEctodermMiceMicroRNAsPluripotent Stem CellsConceptsEmbryonic stem cellsTrophectoderm specificationPreimplantation developmentMurine embryosFirst cell fate decisionCell fate decisionsTight developmental regulationStem cellsInner cell massCandidate miRNAsNumber of miRNAsStages of embryogenesisRole of microRNAsMiRNA expression changesMammalian developmentTranscription factorsDevelopmental regulationEctopic expressionTarget genesExpression changesTrophectodermal cellsTrophectodermMiRNA expressionFunctional roleMiRNAs
2008
MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors
Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR. MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors. Developmental Cell 2008, 14: 843-853. PMID: 18539114, PMCID: PMC2688789, DOI: 10.1016/j.devcel.2008.03.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Bone Marrow CellsCell DifferentiationCell LineageCells, CulturedErythroid CellsErythropoietinGene Expression RegulationGenes, ReporterHematopoietic Stem CellsHumansIntegrin beta3K562 CellsMegakaryocytesMiceMice, Inbred C57BLMicroRNAsModels, BiologicalPlatelet Membrane Glycoprotein IIbProto-Oncogene Proteins c-mybThrombopoietinConceptsMegakaryocyte-erythrocyte progenitorsLineage specificationTranscription factor MYBMiR-150Cell fateLineage fateRegenerative biologyErythroid cellsFunction experimentsMultipotent cellsMegakaryocytic lineageMiRNA expressionPrimary cellsCritical targetModel systemMicroRNAsProgenitorsFateRegulationCellsImportant participantsMYBLineagesMiRNAsBiology
1999
Rat NAP1: cDNA cloning and upregulation by Mpl ligand
Cataldo L, Zhang Y, Lu J, Ravid K. Rat NAP1: cDNA cloning and upregulation by Mpl ligand. Gene 1999, 226: 355-364. PMID: 9931510, DOI: 10.1016/s0378-1119(98)00563-0.Peer-Reviewed Original ResearchMeSH KeywordsAgingAmino Acid SequenceAnimalsBase SequenceBone Marrow CellsCell Cycle ProteinsCell LineageCells, CulturedCloning, MolecularDNA, ComplementaryGene Expression RegulationMolecular Sequence DataNuclear ProteinsNucleosome Assembly Protein 1ProteinsRatsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSequence Homology, Amino AcidThrombopoietinUp-RegulationConceptsMpl ligandNucleosome assembly proteinPrimary bone marrow cellsFull-length cDNASize classesFormation of nucleosomesC-Mpl receptorChromatin reorganizationMultiple size classesAssembly proteinPolymerase chain reaction approachRelaxed circular DNACDNA cloningKb cDNAHematopoietic lineagesKb mRNARecombinant proteinsHematopoietic cytokinesHematopoietic cellsCircular DNAPlatelet precursorsBone marrow cellsHematopoietic tissuesCell linesCDNA