2013
C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells
Di Stefano B, Sardina JL, van Oevelen C, Collombet S, Kallin EM, Vicent GP, Lu J, Thieffry D, Beato M, Graf T. C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature 2013, 506: 235-239. PMID: 24336202, DOI: 10.1038/nature12885.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCCAAT-Enhancer-Binding Protein-alphaCell TransdifferentiationCells, CulturedCellular ReprogrammingChromatinCytosineDeoxyribonuclease IDioxygenasesDNA MethylationDNA-Binding ProteinsEpithelial-Mesenchymal TransitionInduced Pluripotent Stem CellsKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceOctamer Transcription Factor-3Proto-Oncogene ProteinsProto-Oncogene Proteins c-mycSOXB1 Transcription FactorsUp-RegulationConceptsInduced pluripotent stem cellsPluripotent stem cellsTranscription factors Oct4Stem cellsTET2 enzymeChromatin accessibilityPluripotency genesRapid reprogrammingEfficient reprogrammingFactors OCT4B cell precursorsReprogrammingCell precursorsCellsB cellsGenesKLF4MYCSOX2OverexpressionEnzymeExpressionActivation
2012
Blockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia
Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, Wang J, Arnovitz S, Elkahloun A, Price C, Hong GM, Ren H, Kunjamma RB, Neilly MB, Matthews JM, Xu M, Larson RA, Le Beau MM, Slany RK, Liu PP, Lu J, Zhang J, He C, Chen J. Blockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia. Cancer Cell 2012, 22: 524-535. PMID: 23079661, PMCID: PMC3480215, DOI: 10.1016/j.ccr.2012.08.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCell Transformation, NeoplasticDNA MethylationDown-RegulationFms-Like Tyrosine Kinase 3Gene DosageGene Expression Regulation, LeukemicHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHumansLeukemiaMiceMicroRNAsMutationMyeloid Ecotropic Viral Integration Site 1 ProteinMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsNuclear ProteinsProto-Oncogene Proteins c-mycRNA-Binding ProteinsSignal TransductionConceptsMiR-150MiR-150 functionsLeukemic cell growthPathogenesis of leukemiaHoxa9/Meis1Acute leukemiaDysregulation of miRNAsExpression of microRNAsPivotal gatekeeperLeukemiaFunctional axisCell growthLeukemogenesisMYC/MLL fusion proteinsBlockadePathogenesisPosttranscriptional levelExpressionFusion proteinFLT3