Effects of genetic variations on microRNA: target interactions
Liu C, Rennie WA, Carmack CS, Kanoria S, Cheng J, Lu J, Ding Y. Effects of genetic variations on microRNA: target interactions. Nucleic Acids Research 2014, 42: 9543-9552. PMID: 25081214, PMCID: PMC4150780, DOI: 10.1093/nar/gku675.Peer-Reviewed Original ResearchConceptsMiRNA binding sitesGenetic variationGene regulationGenetic variantsMiRNA-mediated gene regulationBinding sitesModulation of miRNAPotential of miRNARare variantsLow mutation frequencyFlanking regionsHuman diseasesVariant densityStructural accessibilityMiRNACommon variantsMutation frequencyMicroRNAsTarget interactionsRegulationStructure alterationsVariantsNew associationsTranscriptomeSites