2006
Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature
Hazony Y, Lu J, St. Hilaire C, Ravid K. Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Nucleic Acids Research 2006, 34: 4416-4428. PMID: 16936310, PMCID: PMC1636359, DOI: 10.1093/nar/gkl578.Peer-Reviewed Original ResearchConceptsCell-specific gene expressionNon-coding regionsRelated DNA sequencesDNA sequencesGene expressionMegakaryocytic lineageUnique transcription factorsCommon DNA sequenceNon-coding sequencesGroup of genesGene promoter sequencesMammalian genomesRegulatory sequencesTranscription factorsPromoter sequencesCross-species differencesGene promoterDNA signaturesLineagesSpecific sequencesCommon sequenceDNA samplesSequencePromoter groupExpression
2005
Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M. Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 2005, 434: 338-345. PMID: 15735639, PMCID: PMC2923337, DOI: 10.1038/nature03441.Peer-Reviewed Original ResearchConceptsMiRNA genesRegulatory motifsNew miRNA genesHuman miRNA genesPost-transcriptional regulationCommon regulatory motifsLikely target genesMammalian genomesDog genomeGene regulationPromoter analysisHuman genomeHuman genesHuman promotersTarget genesUntranslated regionSystematic discoveryGenomeComprehensive identificationGenesNew motifMotifCandidate motifsFunctional elementsPromoter