An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation.
Lu J, Pierron A, Ravid K. An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation. Cancer Research 2003, 63: 6413-23. PMID: 14559831.Peer-Reviewed Original ResearchConceptsEstrogen receptor alphaIB-MECAMCF-7 cellsReceptor alphaHuman breast cancer cell proliferationBreast cancer cell proliferationDifferent adenosine analoguesHuman breast cancer cell line MCF-7Overexpression of ERalphaBreast cancer cell line MCF-7Breast cancer treatmentCancer cell line MCF-7Adenosine analoguesHs578T cellsCancer cell proliferationCell line MCF-7Breast cancer cell typesDifferent breast cancer cell typesCancer cell typesT cellsDrug treatmentN-methyluronamideSelective agonistZR-75Positive cells