2008
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
Li Z, Lu J, Sun M, Mi S, Zhang H, Luo RT, Chen P, Wang Y, Yan M, Qian Z, Neilly MB, Jin J, Zhang Y, Bohlander SK, Zhang DE, Larson RA, Le Beau MM, Thirman MJ, Golub TR, Rowley JD, Chen J. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15535-15540. PMID: 18832181, PMCID: PMC2563085, DOI: 10.1073/pnas.0808266105.Peer-Reviewed Original ResearchConceptsPolo-like kinase 2Genome-wide miRNA expression analysisDistinct miRNA expression patternsMiRs-126/126Normal bone marrow progenitor cellsMiRNA expression patternsCommon translocationBone marrow progenitor cellsGenomic lociMiRNA expression analysisExpression analysisMarrow progenitor cellsAcute myeloid leukemia samplesExpression patternsSpecific miRNAsKinase 2Expression profilesTumor suppressorFunction experimentsGenetic rearrangementsPromoter demethylationColony-forming abilityImportant regulatorAML1-ETOExpression signatures
2007
Altered microRNA expression in human heart disease
Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B, Pu WT. Altered microRNA expression in human heart disease. Physiological Genomics 2007, 31: 367-373. PMID: 17712037, DOI: 10.1152/physiolgenomics.00144.2007.Peer-Reviewed Original ResearchConceptsHeart diseaseDiagnostic groupsHuman heart failureLeft ventricular samplesHeart disease pathogenesisHeart failureIschemic cardiomyopathyDisease groupHeart functionDisease pathogenesisExpression profilesControl groupHuman heart diseaseVentricular samplesClinical diagnosisHuman left ventricular samplesContribution of microRNAsDiseaseFurther studiesImportant regulatorMultiple testingMiRNA expressionMicroRNAsExpressionGroup