Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M. Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 2005, 434: 338-345. PMID: 15735639, PMCID: PMC2923337, DOI: 10.1038/nature03441.Peer-Reviewed Original ResearchConceptsMiRNA genesRegulatory motifsNew miRNA genesHuman miRNA genesPost-transcriptional regulationCommon regulatory motifsLikely target genesMammalian genomesDog genomeGene regulationPromoter analysisHuman genomeHuman genesHuman promotersTarget genesUntranslated regionSystematic discoveryGenomeComprehensive identificationGenesNew motifMotifCandidate motifsFunctional elementsPromoter