2016
MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis
Roden C, Lu J. MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis. Current Stem Cell Reports 2016, 2: 183-196. PMID: 27547713, PMCID: PMC4988405, DOI: 10.1007/s40778-016-0057-1.Peer-Reviewed Original ResearchHematopoietic stem cellsStem cellsPost-transcriptional gene regulation mechanismSpecific gene expression programsPost-transcriptional gene expressionSmall non-coding RNAsGene expression programsLeukemia stem cellsGene regulation mechanismsFunction of miRNAsNon-coding RNAsStudy of miRNAsRole of miRNAsCell signaling pathwaysLSC biologyCancer stem cell conceptStem cell fieldEpigenetic machineryExpression programsHSC emergenceEpigenetic programsStem cell conceptEpigenetic regulatorsDifferentiated progenyHSC nichemiR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells
Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JC, Naldini L, Dick JE. miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. Cancer Cell 2016, 29: 214-228. PMID: 26832662, PMCID: PMC4749543, DOI: 10.1016/j.ccell.2015.12.011.Peer-Reviewed Original ResearchConceptsLeukemia stem cellsMiR-126Human acute myeloid leukemia stem cellsAcute myeloid leukemia stem cellsMyeloid leukemia stem cellsPI3K/Akt/mTORMiR-126 expressionAkt/mTORMalignant hematopoietic stem cellsMiR-126 regulationStem cellsMiR-126 targetsLSC activityLSC quiescenceAML samplesChemotherapy resistanceHematopoietic stem cellsHematopoietic stem cell cyclingMiRNA signatureCell cycle progressionLSC functionCycle progressionStem cell cyclingSignature miRNAsCell cycling
2010
MicroRNA miR-125a controls hematopoietic stem cell number
Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT. MicroRNA miR-125a controls hematopoietic stem cell number. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14229-14234. PMID: 20616003, PMCID: PMC2922532, DOI: 10.1073/pnas.0913574107.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsStem cell pool sizeStem cell stateLong-term hematopoietic stem cellsCell-autonomous mannerStem cellsStem cell populationCell pool sizeMiR-125aStem cell numbersHematopoietic stem cell numbersEnzyme DicerImmature hematopoietic progenitorsHematopoietic differentiationMutant animalsCell statesProgenitor cell apoptosisMicroRNA processing enzyme DicerMicroRNA clusterProapoptotic genesHSPC populationsHematopoietic expansionSpecific microRNAsUnique microRNAsHSPC apoptosis
2009
Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
Popovic R, Riesbeck LE, Velu CS, Chaubey A, Zhang J, Achille NJ, Erfurth FE, Eaton K, Lu J, Grimes HL, Chen J, Rowley JD, Zeleznik-Le NJ. Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Blood 2009, 113: 3314-3322. PMID: 19188669, PMCID: PMC2665896, DOI: 10.1182/blood-2008-04-154310.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell DifferentiationCell ProliferationCell Transformation, NeoplasticCells, CulturedEmbryonic Stem CellsGene Expression RegulationHistone-Lysine N-MethyltransferaseLeukemiaMiceMice, Inbred C57BLMicroRNAsMolecular Sequence DataMyeloid-Lymphoid Leukemia ProteinRecombinant Fusion ProteinsSequence Homology, Nucleic AcidUp-RegulationConceptsMLL fusion proteinsHox genesMiR-196bLeukemogenic MLL fusion proteinsFusion proteinEmbryonic stem cell differentiationStem cell differentiationDifferentiated hematopoietic cellsShort-term hematopoietic stem cellsMixed lineage leukemia (MLL) geneBone marrow progenitor cellsLeukemia developmentHOXA clusterHematopoietic stem cellsPrimary leukemia samplesChimeric proteinMarrow progenitor cellsHematopoietic lineagesCell differentiationLeukemia geneFusion contributesChromosomal translocationsHematopoietic cellsGenesStem cells