2012
miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish
Stahlhut C, Suárez Y, Lu J, Mishima Y, Giraldez AJ. miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish. Development 2012, 139: 4356-4365. PMID: 23132244, PMCID: PMC3509730, DOI: 10.1242/dev.083774.Peer-Reviewed Original ResearchConceptsMiR-1/206Post-transcriptional modulatorsMiRNA-target interactionsMiR-1Appropriate physiological responsesRegulation of VEGFAZebrafish developmentEmbryonic developmentTarget protectorNovel functionPrecise regulationGene expressionMorphogenetic activityDevelopmental angiogenesisPutative targetsRegulate angiogenesisEssential processMiR-206Physiological responsesCellular communicationVEGFA expressionGrowth factorVascular endothelial growth factorExpressionAngiogenesis
2008
The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells
Chou YF, Chen HH, Eijpe M, Yabuuchi A, Chenoweth JG, Tesar P, Lu J, McKay RD, Geijsen N. The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells. Cell 2008, 135: 449-461. PMID: 18984157, PMCID: PMC2767270, DOI: 10.1016/j.cell.2008.08.035.Peer-Reviewed Original ResearchConceptsStem cell linesGrowth factor environmentPluripotent stateTissue of originCell linesEmbryonic stem cell linesPluripotent ground stateBlastocyst embryosStem cell identityCell-cell interactionsGrowth factor conditionsStem cell typesFactor environmentPostimplantation epiblastCell identityES cellsDevelopmental stagesCell typesStem cellsFunctional differencesCritical roleEmbryosGrowth factorGrowth factor milieuEpiSCs