2015
Characterization of the mammalian miRNA turnover landscape
Guo Y, Liu J, Elfenbein SJ, Ma Y, Zhong M, Qiu C, Ding Y, Lu J. Characterization of the mammalian miRNA turnover landscape. Nucleic Acids Research 2015, 43: 2326-2341. PMID: 25653157, PMCID: PMC4344502, DOI: 10.1093/nar/gkv057.Peer-Reviewed Original ResearchConceptsMiRNA turnoverStable small RNAsMammalian cell typesCultured mammalian cellsSubset of miRNAsTurnover kineticsMiRNA biogenesisMost miRNAsMiR-222-5pNucleotide biasSmall RNAsMiRNA maturationMammalian cellsSame miRNAMiRNA poolExpression profilingHsp90 associationSequence determinantsDeep sequencingHsp90 inhibitionTurnover rateMiRNA isoformsDifferent turnover ratesSequence featuresCell typesmicroRNA Expression Profiling: Technologies, Insights, and Prospects
Roden C, Mastriano S, Wang N, Lu J. microRNA Expression Profiling: Technologies, Insights, and Prospects. Advances In Experimental Medicine And Biology 2015, 888: 409-421. PMID: 26663195, DOI: 10.1007/978-3-319-22671-2_21.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell Line, TumorDisease Models, AnimalGene Expression ProfilingGene Expression Regulation, NeoplasticHigh-Throughput Nucleotide SequencingHumansMicroRNAsMolecular Sequence DataNeoplasmsReverse Transcriptase Polymerase Chain ReactionSequence Homology, Nucleic AcidSignal TransductionConceptsLong small noncoding RNAsExpression profilingMiRNA isoformsMiRNA expressionProfiling technologiesDiverse biological processesSingle-cell variabilitySmall noncoding RNAsMiRNA profiling technologiesGlobal miRNA expressionNext-generation sequencingNoncoding RNAsCell variabilitySingle-molecule measurementsBiological functionsBiological processesTumor suppressorMicroRNA researchQuantitative RT-PCRCareful experimental designMiRNAsIsoformsRT-PCRProfilingExpression
2007
MicroRNA Expression Profiles in Acute Myeloid Leukemia with Common Translocations.
Li Z, Lu J, Sun M, Mi S, Zhang H, Luo R, Qian Z, Neilly M, Wang Y, Jin J, Zhang Y, Bohlander S, Larson R, LeBeau M, Thirman M, Golub T, Rowley J, Chen J. MicroRNA Expression Profiles in Acute Myeloid Leukemia with Common Translocations. Blood 2007, 110: 3181. DOI: 10.1182/blood.v110.11.3181.3181.Peer-Reviewed Original ResearchAcute myeloid leukemiaTarget genesExpression profilesDNA copy number amplificationsProtein-coding genesExpression profiling methodsImportant target genesMyeloid leukemiaNon-coding RNAsCritical target genesNormal controlsTreatment of AMLCBF acute myeloid leukemiaCopy number amplificationMiRNA expression profilesDevelopment of AMLCommon translocationEpigenetic regulationMicroRNA expression profileWide analysisComplex genetic alterationsExpression profilingDNA microarraysBiological roleTumor suppressor