Dysregulation in keratinocytes drives systemic lupus erythematosus onset
Tian J, Shi L, Zhang D, Yao X, Zhao M, Kumari S, Lu J, Yu D, Lu Q. Dysregulation in keratinocytes drives systemic lupus erythematosus onset. Cellular & Molecular Immunology 2024, 1-14. PMID: 39627610, DOI: 10.1038/s41423-024-01240-z.Peer-Reviewed Original ResearchSystemic lupus erythematosusDendritic cellsT cellsActivated CD4+ T cellsDisease onsetSystemic lupus erythematosus onsetCD4+ T cellsHallmarks of systemic lupus erythematosusHuman systemic lupus erythematosusSkin lesions of patientsEtiology of systemic lupus erythematosusEffector T cellsLocal draining lymph nodesActivated dendritic cellsDraining lymph nodesMultiorgan autoimmune disorderSystemic autoimmune diseaseLesions of patientsPeroxisome proliferator-activated receptor gammaImmune cell dysregulationProliferator-activated receptor gammaInterferon regulatory factor 3Type I interferonII-dependent mannerRegulatory factor 3