2024
Dysregulation in keratinocytes drives systemic lupus erythematosus onset
Tian J, Shi L, Zhang D, Yao X, Zhao M, Kumari S, Lu J, Yu D, Lu Q. Dysregulation in keratinocytes drives systemic lupus erythematosus onset. Cellular & Molecular Immunology 2024, 1-14. PMID: 39627610, DOI: 10.1038/s41423-024-01240-z.Peer-Reviewed Original ResearchSystemic lupus erythematosusDendritic cellsT cellsActivated CD4+ T cellsDisease onsetSystemic lupus erythematosus onsetCD4+ T cellsHallmarks of systemic lupus erythematosusHuman systemic lupus erythematosusSkin lesions of patientsEtiology of systemic lupus erythematosusEffector T cellsLocal draining lymph nodesActivated dendritic cellsDraining lymph nodesMultiorgan autoimmune disorderSystemic autoimmune diseaseLesions of patientsPeroxisome proliferator-activated receptor gammaImmune cell dysregulationProliferator-activated receptor gammaInterferon regulatory factor 3Type I interferonII-dependent mannerRegulatory factor 3
2013
Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity
Bryniarski K, Ptak W, Jayakumar A, Püllmann K, Caplan MJ, Chairoungdua A, Lu J, Adams BD, Sikora E, Nazimek K, Marquez S, Kleinstein SH, Sangwung P, Iwakiri Y, Delgato E, Redegeld F, Blokhuis BR, Wojcikowski J, Daniel AW, Kormelink T, Askenase PW. Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. Journal Of Allergy And Clinical Immunology 2013, 132: 170-181.e9. PMID: 23727037, PMCID: PMC4176620, DOI: 10.1016/j.jaci.2013.04.048.Peer-Reviewed Original ResearchConceptsCutaneous contact sensitivityEffector T cellsT cell toleranceT cellsExosome-like nanovesiclesContact sensitivityCS-effector T cellsMiRNA-150Regulatory T cellsAntigen-specific mannerSuppressor T cellsRole of antibodiesAdoptive cell transfer modelCell transfer modelT cell regulationLight chainSuppressor cellsLymph nodesReactive haptenImmune suppressionMicroRNA-150Systemic injectionAntibody light chainIntravenous injectionSpleen cells