2010
Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia
Mi S, Li Z, Chen P, He C, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 3710-3715. PMID: 20133587, PMCID: PMC2840429, DOI: 10.1073/pnas.0914900107.Peer-Reviewed Original ResearchConceptsMouse bone marrow progenitor cellsMiRNA clusterTarget genesMLL fusionsBone marrow progenitor cellsMiR-17Marrow progenitor cellsCell differentiationDNA copy number amplificationsWild-type MLLProgenitor cellsRelevant target genesHistone H3 acetylationPotential target genesMLL fusion genesCopy number amplificationDevelopment of MLLH3K4 trimethylationIndividual miRNAsH3 acetylationMixed lineage leukemiaCell cycleHuman cellsDirect bindingMiRNAs
2007
MicroRNA Expression Profiles in Acute Myeloid Leukemia with Common Translocations.
Li Z, Lu J, Sun M, Mi S, Zhang H, Luo R, Qian Z, Neilly M, Wang Y, Jin J, Zhang Y, Bohlander S, Larson R, LeBeau M, Thirman M, Golub T, Rowley J, Chen J. MicroRNA Expression Profiles in Acute Myeloid Leukemia with Common Translocations. Blood 2007, 110: 3181. DOI: 10.1182/blood.v110.11.3181.3181.Peer-Reviewed Original ResearchAcute myeloid leukemiaTarget genesExpression profilesDNA copy number amplificationsProtein-coding genesExpression profiling methodsImportant target genesMyeloid leukemiaNon-coding RNAsCritical target genesNormal controlsTreatment of AMLCBF acute myeloid leukemiaCopy number amplificationMiRNA expression profilesDevelopment of AMLCommon translocationEpigenetic regulationMicroRNA expression profileWide analysisComplex genetic alterationsExpression profilingDNA microarraysBiological roleTumor suppressor