2019
MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
Hu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J, Schwartz M, King MC, Krause DS, Guo S. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nature Communications 2019, 10: 1695. PMID: 30979898, PMCID: PMC6461646, DOI: 10.1038/s41467-019-09636-6.Peer-Reviewed Original ResearchConceptsCell fate reprogrammingChromatin accessibilityActin cytoskeletonSomatic cell reprogrammingPluripotency transcription factorsGlobal chromatin accessibilityGenomic accessibilityCytoskeleton (LINC) complexCell reprogrammingCytoskeletal genesTranscription factorsReprogrammingPluripotencyChromatinCytoskeletonMKL1Unappreciated aspectPathwayNuclear volumeNucleoskeletonSUN2CellsActivationGenesExpression
2004
Properties of Ets-1 Binding to Chromatin and Its Effect on Platelet Factor 4 Gene Expression
Lu J, Pazin MJ, Ravid K. Properties of Ets-1 Binding to Chromatin and Its Effect on Platelet Factor 4 Gene Expression. Molecular And Cellular Biology 2004, 24: 428-441. PMID: 14673175, PMCID: PMC303331, DOI: 10.1128/mcb.24.1.428-441.2004.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsChromatinDetergentsGene Expression RegulationHumansMegakaryocytesMiceNucleosomesPlatelet Factor 4Platelet Glycoprotein GPIb-IX ComplexPlatelet Membrane GlycoproteinsPromoter Regions, GeneticProto-Oncogene Protein c-ets-1Proto-Oncogene ProteinsProto-Oncogene Proteins c-etsRatsSarcosineTranscription FactorsConceptsEts-1 bindsPromoter activityLineage-specific factorsChromatin immunoprecipitation assaysEts-1 siteGlycoprotein IIbLineage-specific promotersNaked DNAGPIIb promoterTranscriptional regulationAccessory factorsPF4 promoterTranscription factorsHypersensitive sitesImmunoprecipitation assaysHematopoietic lineagesDNase IChromatinGene expressionPromoter activationPromoterProximal regionModel systemFactor 4ET-1