MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander SK, Le Beau MM, Larson RA, Golub TR, Rowley JD, Chen J. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 19971-19976. PMID: 18056805, PMCID: PMC2148407, DOI: 10.1073/pnas.0709313104.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaAcute leukemiaMyeloid leukemiaExpression signaturesCommon acute leukemiaCommon childhood cancerCommon cytogenetic subtypeMicroRNA expression signatureNormal control samplesAcute leukemia samplesBetter prognosisChildhood cancerReal-time PCRCytogenetic subtypesMiR-223LeukemiaMiR-128aLeukemia samplesPromoter hypomethylationMiR-128MicroRNA expressionDiagnosisRegulation of expressionMicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia.
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly M, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander S, Le M, Larson R, Golub T, Rowley J, Chen J. MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia. Blood 2007, 110: 231. DOI: 10.1182/blood.v110.11.231.231.Peer-Reviewed Original ResearchAcute myeloid leukemiaAcute lymphoblastic leukemiaAcute leukemiaLymphoblastic leukemiaMyeloid leukemiaMiR-128aOverall survival rateExpression signaturesCommon cytogenetic subtypeMicroRNA expression signatureAcute leukemia samplesDevelopment of cancerFlow cytometric methodHuman acute leukemiaQuantitative real-time PCRReal-time PCRT cellsCytogenetic subtypesNormal controlsSurvival rateMiR-223Vivo modelLeukemiaNovel markerTarget genes