COP9 Signalosome Interacts ATP-dependently with p97/Valosin-containing Protein (VCP) and Controls the Ubiquitination Status of Proteins Bound to p97/VCP*
Cayli S, Klug J, Chapiro J, Fröhlich S, Krasteva G, Orel L, Meinhardt A. COP9 Signalosome Interacts ATP-dependently with p97/Valosin-containing Protein (VCP) and Controls the Ubiquitination Status of Proteins Bound to p97/VCP*. Journal Of Biological Chemistry 2009, 284: 34944-34953. PMID: 19826004, PMCID: PMC2787357, DOI: 10.1074/jbc.m109.037952.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAdenosine TriphosphateAmino Acid SequenceAnimalsCell Cycle ProteinsCOP9 Signalosome ComplexHumansMiceMolecular Sequence DataMultiprotein ComplexesNIH 3T3 CellsPeptide HydrolasesProtein BindingProtein SubunitsRecombinant Fusion ProteinsUbiquitinationValosin Containing ProteinConceptsP97/valosin-containing proteinValosin-containing proteinUbiquitin/proteasome systemCOP9 signalosomeUbiquitination statusUbiquitinated proteinsProteasome degrades ubiquitinated proteinsATP-dependent mannerProteasome regulatory particleATP-dependent complexesUbiquitin E3 ligasesOligoubiquitin chainsCSN complexE3 ligasesPolyubiquitinated substratesRegulatory particleIsopeptidase activityProteasome systemDeubiquitinase USP15Subunit 5ProteinSignalosomeDegradation pathwayCSN5Key mediator