2021
Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial
Letzen BS, Malpani R, Miszczuk M, de Ruiter QMB, Petty CW, Rexha I, Nezami N, Laage-Gaupp F, Lin M, Schlachter TR, Chapiro J. Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial. Clinical Imaging 2021, 78: 194-200. PMID: 34022765, PMCID: PMC8364875, DOI: 10.1016/j.clinimag.2021.05.007.Peer-Reviewed Original ResearchConceptsConventional trans-arterial chemoembolizationMedian overall survivalProspective clinical trialsLipiodol depositionTumor responsePredictive biomarkersClinical trialsModified Response Evaluation CriteriaPost-TACE CTResponse Evaluation CriteriaMetastatic liver cancerKaplan-Meier analysisTrans-arterial chemoembolizationTumor response criteriaLiver tumor responsePrediction of survivalSelective drug targetingArterial embolizationLiver metastasesOverall survivalBland-Altman plotsTransarterial chemoembolizationPortal veinTumor respondersHepatocellular carcinoma
2019
Quantitative MRI for Assessment of Treatment Outcomes in a Rabbit VX2 Hepatic Tumor Model
Keller S, Chapiro J, Brangsch J, Reimann C, Collettini F, Sack I, Savic LJ, Hamm B, Goldberg SN, Makowski M. Quantitative MRI for Assessment of Treatment Outcomes in a Rabbit VX2 Hepatic Tumor Model. Journal Of Magnetic Resonance Imaging 2019, 52: 668-685. PMID: 31713973, DOI: 10.1002/jmri.26968.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingTranscatheter arterial embolizationHepatic tumor modelDiffusion-weighted imagingFunctional MRI sequencesRadiofrequency ablationTreatment outcomesHepatocellular carcinomaAnaplastic squamous cell carcinomaMRI sequencesTumor modelSecondary liver cancerSquamous cell carcinomaConventional magnetic resonance imagingHigh tumor vascularityDifferent treatment settingsCommon cancer typesFunctional magnetic resonance imagingQuantitative magnetic resonance imagingFuture MRI studiesLocoregional interventionsArterial embolizationLiver functionCell carcinomaInterventional treatment