2021
Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves
Santos E, Silva-Filho S, Santos Radai J, Arena A, Fraga T, Lima Cardoso C, Croda J, Leite Kassuya C. Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves. Journal Of Ethnopharmacology 2021, 278: 114308. PMID: 34102271, DOI: 10.1016/j.jep.2021.114308.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesMethylthiazolyldiphenyl-tetrazolium bromideComplete Freund's adjuvantAnti-inflammatory featuresEthanolic extractLong-term treatmentBacillus Calmette-GuerinInflammatory evaluationInflammatory parametersConventional medicationsDaily administrationNeutrophil activityPersistent inflammationRheumatic diseasesFreund's adjuvantInflammatory aspectsPleurisy modelTraditional folk medicineSwiss miceCalmette-GuerinInflammatory diseasesC57BL6 miceVivo modelExperimental modelAdverse effects
2020
Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice
Kassuya R, Radai J, Macorini L, Nunes V, Salvador M, Leite P, Oliveira R, Croda J, Arena A, Kassuya C. Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice. Inflammopharmacology 2020, 29: 439-450. PMID: 32910315, DOI: 10.1007/s10787-020-00752-0.Peer-Reviewed Original ResearchMeSH KeywordsAmaranthaceaeAnimalsAnti-Inflammatory AgentsAntitubercular AgentsCarrageenanDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLMicrobial Sensitivity TestsMycobacterium tuberculosisPlant ExtractsPleurisyRatsRats, WistarConceptsSwiss miceIL-1β levelsC57BL-6 miceEthanolic extractInflammation/infectionSafe new drugsM. tuberculosis growthMechanical hyperalgesiaInflammatory parametersOral treatmentIL-1βPleurisy modelMinimum inhibitory concentrationPharmacoeconomic perspectiveC57BL6 miceComplete adjuvantSubcutaneous injectionOral administrationWistar ratsMiceMycobacterium tuberculosisNew drugsHealth benefitsTuberculosis growthInhibitory concentration
2017
Anti-inflammatory, antimycobacterial and genotoxic evaluation of Doliocarpus dentatus
Ishikawa R, Leitão M, Kassuya R, Macorini L, Moreira F, Cardoso C, Coelho R, Pott A, Gelfuso G, Croda J, Oliveira R, Kassuya C. Anti-inflammatory, antimycobacterial and genotoxic evaluation of Doliocarpus dentatus. Journal Of Ethnopharmacology 2017, 204: 18-25. PMID: 28392458, DOI: 10.1016/j.jep.2017.04.004.Peer-Reviewed Original ResearchConceptsMinimal inhibitory concentrationDoliocarpus dentatusPeripheral leukocyte countAnti-inflammatory agentsMechanical hypersensitivityUrine retentionCarrageenan modelLeukocyte countOral administrationLeukocyte migrationInflammation processPhagocytic activityPhagocytosis testMycobacterium tuberculosisMicronucleus testSignificant decreaseEthanolic extractGenotoxic aspectsGenotoxic evaluationInhibitory concentrationAntimycobacterial activitySafe useBetulinic acidMagnetic resonanceCount