2018
Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Warsinske H, Rao A, Moreira F, Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response. JAMA Network Open 2018, 1: e183779. PMID: 30646264, PMCID: PMC6324428, DOI: 10.1001/jamanetworkopen.2018.3779.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsBrazilChildCohort StudiesDisease ProgressionFemaleGenes, BacterialGenetic MarkersHumansLatent TuberculosisMaleMiddle AgedMolecular TypingMycobacterium tuberculosisReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, BacterialSeverity of Illness IndexTuberculosisYoung AdultConceptsTB scoreAdolescent cohort studyNegative predictive valueTreatment responseTB diseaseCohort studyTuberculosis infectionTriage testPositron emission tomography-computed tomography scanPredictive valueLatent M tuberculosis infectionLatent Mycobacterium tuberculosis infectionPrimary health care clinicsHigh negative predictive valueCulture-positive adultsM tuberculosis infectionWhole bloodMycobacterium tuberculosis infectionEnd of treatmentHealth care clinicsCase-control studyIndependent prospective cohortsDiagnosis of tuberculosisSlower treatment responseCase-control cohort
2017
Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
de Oliveira S, Trajman A, Paniago A, Motta-Castro A, Ruffino-Netto A, Maciel E, Croda J, da Gloria Bonecini-Almeida M. Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals. Jornal Brasileiro De Pneumologia 2017, 43: 215-218. PMID: 28746533, PMCID: PMC5687953, DOI: 10.1590/s1806-37562016000000125.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsBrazilCD4 Lymphocyte CountCross-Sectional StudiesFeasibility StudiesFemaleHumansInfectious Disease Incubation PeriodInterferon-gamma Release TestsLatent TuberculosisMaleMiddle AgedReproducibility of ResultsSurveys and QuestionnairesTuberculin TestConceptsInterferon-gamma releaseIndeterminate resultsHIV/AIDSIGRA resultsTuberculin skin test resultsMultivariate logistic regression modelTuberculin skin testSkin test resultsCost-effectiveness studiesLogistic regression modelsAdvanced immunosuppressionAdjusted ORsSkin testClinical variablesMedical recordsHigh prevalenceHigh riskPatientsIGRARoutine useKappa statisticsPLWHAAIDSRegression modelsKappa