2024
BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial
Messina N, Pittet L, McDonald E, Moore C, Barry S, Bonten M, Byrne A, Campbell J, Croda J, Croda M, Dalcolmo M, de Almeida e Val F, de Oliveira R, dos Santos G, Douglas M, Gardiner K, Gwee A, Jardim B, Kollmann T, Lacerda M, Lucas M, Lynn D, Manning L, Marshall H, O’Connell A, Perrett K, Post J, Prat-Aymerich C, Rocha J, Rodriguez-Baño J, Wadia U, Warris A, Davidson A, Curtis N, Group T. BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial. Journal Of Infection 2024, 89: 106245. PMID: 39127450, PMCID: PMC11409612, DOI: 10.1016/j.jinf.2024.106245.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinBreakthrough COVID-19Healthcare workersSevere COVID-19Risk of severe COVID-19Placebo groupSymptomatic COVID-19BCG-DenmarkRisk of symptomatic COVID-19International randomised controlled trialRandomised controlled trialsBacille Calmette-Guerin vaccineVaccination of healthcare workersHealthcare centresSARS-CoV-2 testingAsymptomatic SARS-CoV-2 infectionRandomised 1:1SARS-CoV-2 infectionCOVID-19MITT populationControlled trialsHealthcareIntradermal doseModified intentionImmunomodulatory effectsEffect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial
dos Santos P, Messina N, de Oliveira R, da Silva P, Puga M, Dalcolmo M, dos Santos G, de Lacerda M, Jardim B, de Almeida e Val F, Curtis N, Andrews J, Croda J. Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial. The Lancet Infectious Diseases 2024, 24: 594-601. PMID: 38423021, PMCID: PMC11111441, DOI: 10.1016/s1473-3099(23)00818-6.Peer-Reviewed Original ResearchConceptsQuantiFERON-TB GoldPlacebo groupEffect of BCG vaccinationBCG vaccinationBCG groupBCG-DenmarkHealth-care workersNegative baseline resultsMonths of treatmentMycobacterium tuberculosis infectionAdult pulmonary tuberculosisQuantiFERON-TBMedian ageRandomised controlled trialsPulmonary tuberculosisNo significant differenceEfficacy outcomesTuberculosis infectionClinical trialsControlled trialsEffect of vaccinationTreatment drugsTuberculosis preventionSubstudySignificant difference
2023
Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
Messina N, Sperotto M, Puga M, da Silva P, de Oliveira R, Moore C, Pittet L, Jamieson T, Dalcolmo M, dos Santos G, Jardim B, Lacerda M, Curtis N, Croda J. Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination. Frontiers In Immunology 2023, 14: 1172851. PMID: 37465688, PMCID: PMC10352084, DOI: 10.3389/fimmu.2023.1172851.Peer-Reviewed Original ResearchMeSH KeywordsAntibody FormationBCG VaccineChAdOx1 nCoV-19COVID-19COVID-19 VaccinesHumansImmunoglobulin GVaccinationConceptsRecent BCG vaccinationBCG vaccinationAntibody responseVaccine platformAnti-spike IgG responseCOVID-19 vaccinationCOVID-19 vaccineCoronaVac vaccinationPrior vaccinationVaccine responsesIgG responsesSecond doseIgG antibodiesHealthcare workersVaccinationChAdOx1CoronaVacCOVID-19VaccineMultiple factorsResponsePlaceboDoseTrialsAntibodiesRandomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers
Pittet L, Messina N, Orsini F, Moore C, Abruzzo V, Barry S, Bonnici R, Bonten M, Campbell J, Croda J, Dalcolmo M, Gardiner K, Gell G, Germano S, Gomes-Silva A, Goodall C, Gwee A, Jamieson T, Jardim B, Kollman T, Lacerda M, Lee K, Lucas M, Lynn D, Manning L, Marshall H, McDonald E, Munns C, Nicholson S, O’Connell A, de Oliveira R, Perlen S, Perrett K, Prat-Aymerich C, Richmond P, Rodriguez-Baño J, dos Santos G, da Silva P, Teo J, Villanueva P, Warris A, Wood N, Davidson A, Curtis N. Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers. New England Journal Of Medicine 2023, 388: 1582-1596. PMID: 37099341, PMCID: PMC10497190, DOI: 10.1056/nejmoa2212616.Peer-Reviewed Original ResearchConceptsBacille Calmette-GuerinModified intention-to-treat populationIntention-to-treat populationSevere COVID-19Placebo groupSymptomatic COVID-19Health care workersBCG-DenmarkPlacebo-controlled trialCare workersRisk of severe COVID-19Double-blindSaline placeboRisk of symptomatic COVID-19Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Negative testRandomized trialsRespiratory syndrome coronavirus 2Hazard ratioPrimary outcomeBCG vaccinationTrial definitionSyndrome coronavirus 2Risk difference
2022
Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, Fox G, Carvalho A, Chan P, Croda J, Hill P, Lopez-Varela E, Donkor S, Fielding K, Graham S, Espinal M, Kampmann B, Reingold A, Huerga H, Villalba J, Grandjean L, Sotgiu G, Egere U, Singh S, Zhu L, Lienhardt C, Denholm J, Seddon J, Whalen C, García-Basteiro A, Triasih R, Chen C, Singh J, Huang L, Sharma S, Hannoun D, Del Corral H, Mandalakas A, Malone L, Ling D, Kritski A, Stein C, Vashishtha R, Boulahbal F, Fang C, Boom W, Netto E, Lemos A, Hesseling A, Kay A, Jones-López E, Horsburgh C, Lange C, Andrews J. Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis. The Lancet Global Health 2022, 10: e1307-e1316. PMID: 35961354, PMCID: PMC10406427, DOI: 10.1016/s2214-109x(22)00283-2.Peer-Reviewed Original ResearchConceptsInfant BCG vaccinationBCG vaccinationExtrapulmonary tuberculosisCohort studyIndividual participant dataPulmonary tuberculosisParticipant dataSystematic reviewIndividual-level participant dataPositive tuberculin skin testMultivariable logistic regression analysisTuberculin skin testTuberculosis infection statusParticipant-level dataLogistic regression analysisAge-specific impactStudy-level random effectWeb of ScienceIncident tuberculosisPrevious tuberculosisTuberculosis developmentSecondary outcomesTuberculosis contactsPrimary outcomeSkin test
2021
BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)
Pittet L, Messina N, Gardiner K, Orsini F, Abruzzo V, Bannister S, Bonten M, Campbell J, Croda J, Dalcolmo M, Elia S, Germano S, Goodall C, Gwee A, Jamieson T, Jardim B, Kollmann T, Lacerda M, Lee K, Legge D, Lucas M, Lynn D, McDonald E, Manning L, Munns C, Perrett K, Aymerich C, Richmond P, Shann F, Sudbury E, Villanueva P, Wood N, Lieschke K, Subbarao K, Davidson A, Curtis N, Abreu C, Abruzzo V, Addlem L, Agius S, Barbosa A, Alamrousi A, Santos A, Al-Hindawi Y, Da Silveira S, Cruz L, Anderson J, Anthony C, Pereira A, Almajano F, Arnold A, Arrowsmith B, Azzopardi K, Marti C, Bahaduri T, Bannister S, Barney S, Barrera L, Barriocanal A, Barros D, Barry S, Bartlett A, Muranaka L, Baulman T, Bealing M, Beardsley J, Gutierrez A, Bell J, Benson S, Bennett-Wood V, Bergant N, Barbosa F, Bijllaardt W, Bimboese P, Andrade C, Blake S, Blauwendraat K, Boersma W, Garcia P, Bonnici R, Bonten M, Boon A, Bourke A, Bowes K, Brasil L, Brophy C, Botten R, Buchanan S, Bucholc J, Burns A, Burrell E, Bustos N, Byrne B, Byrne A, Calbo E, Montes J, Camesella B, Campbell J, Cangas A, Carlin J, Roque M, Diogo R, Carvalho E, Casas I, Castro E, Castro R, Catterick H, Escobar R, Chan J, Cheah J, Chern T, Chengodu T, Ciaverella M, Clark S, Espindola M, Cobbledick A, Colaco C, Collopy S, Comella P, Corbett M, Castro G, Costa E, Coya R, Crawford N, Croda J, Cruz A, Curtis N, Cushnahan J, Czajko A, da Silva R, Daitiri B, Dalcolmo M, Dalton K, Dao A, Davidson A, Dawe P, Dawson D, Costa M, De La Cruz K, de Serna A, de Morais Batista F, de Oliveira A, del Rey Morillo R, Desylva M, Dijkstra H, Dixon R, Lopez M, Dominguez J, Doran C, Castellano A, Dos Santos G, Lencina J, Silva D, Douglas M, Dunn R, Dunn A, Dunnill J, Eden G, Edmund H, Eiffler N, Elborough H, Elia S, Elkington O, England M, Ayala W, Esteve M, Evans N, Evans S, Ewe K, Álvarez M, Fahey K, Fairweather J, Faustman D, Silva E, Fernandez M, Fidler G, Filius P, Finn A, Finucane C, Firth S, Fletcher E, Flynn C, Flynn L, Fouracre L, Fowler S, Freitas T, Furtado A, Oliveira M, Santos A, Gonçalves L, Galletta L, Gama L, Gamage D, Ganpat R, García C, Croda M, Gardiner K, Gardiner E, Gell G, Oliveira A, Germano S, Gibbons M, Gibson C, Gifford A, Poderos T, Ginsberg A, Gisolf J, Gladanac B, Glenn P, Godinho V, Santos M, Goikoetxea J, Goldenberg T, Gomes A, Marcos S, Rico C, Goodall C, Gordon V, Greven F, Capella A, Griffith L, Guo C, Campos D, Cuadra M, Gwee A, Hall R, Hall L, Hamilton K, Hannan M, Harbech H, Harding A, Haker N, Harrison R, Hassing R, Rosa T, Haywood Z, Heath C, Henare N, Andrade P, Herrmann S, Hill E, Hilton S, Huijbens D, Hutton H, James J, Jamieson T, Janssen A, Jardim B, Jardim T, Jarvis L, Jenkins N, Jones J, Jones J, Jones K, Jorge L, Vilegas M, Joshi S, Joyce R, Junior J, Kandasamy R, Karunanayake A, Karuppasamy H, Keeble T, Kent J, Kloeg P, Kluytmans J, Knight B, Kollmann T, Korman T, Krastev A, Krieg M, La N, Lacerda M, Lacoma A, Lagunday R, Lalich D, Latkovic E, Latorre I, Leandro P, Lee K, Legge D, Lemmers T, Leurink T, Lieschke K, Lim K, Lockhart G, Bogéa C, Santos K, Marques R, Lucas M, Lynn D, Lynn M, Freitas M, Ma N, Macalister S, Machado C, Ramos M, Machingaifa F, Maia I, Maia B, Malley R, Manning L, Manton S, Carrerero J, Barriocanal A, Alves C, Pereira R, Arruda B, Marins A, Marshall H, Markow A, Martin C, Almeida K, Mather W, Mathers M, Gomes F, Tadokoro M, Mazarakis N, Mazurega K, McAlister S, McAndrews A, McDonald E, McDonald F, McElroy R, McMillan M, McMullan B, McPhate N, Mead L, Meehan A, Meek B, Melo R, Mena G, Mesquita D, Messina N, Mezzetti I, Vieira H, Miller S, Mitchell K, Mitchell M, Mojeed J, Molenaar K, Molina G, Molina B, Montgomery L, Moore C, Moore J, Moorlag S, Morawakage T, Moss J, Moyle W, Mulholland K, Munns C, Nascimento E, Navarrette N, Netea M, Neves J, Newman G, Ngien B, Nguyen J, Nguyen K, Noonan F, Norton W, O’Donnell M, O’Bryan J, O’Connell A, Odoi S, O’Donnell L, Oliveira R, Oliveira M, Oliveira T, Oliveira I, Olivier N, Olivio L, Ong B, Ong J, Ong J, Onysk J, Ooi I, Oppedisano F, Orsini F, Ortika B, Group O, Otsuka A, Overton K, Owens R, Paes R, Palasanthiran P, Jiménez V, Pandine G, Parkin K, Hernandez A, Paternotte N, Paterson D, Souza A, Pelayo L, Pell C, Pelser S, Pereira H, Pereira G, Perez G, Perez C, Porcuna T, Perlen S, Perrett K, Floy A, Pitkin S, Pittet L, Pon R, Calderón I, Post J, Power C, Prado C, Prajitno E, Prat-Aymerich C, Preijers L, Puga M, Queiroz E, Quinn L, Rak A, Figueiredo L, de Arellano E, Ramos P, Oliveira K, Ren J, Reynolds S, Rhodes S, Santos C, Richards C, Richmond P, Richmond H, Souza A, Rocha J, Rodrigues T, Rodrigues L, Rodrigues B, Fernandes I, Rodríguez-Baño J, Roescher N, Rogers S, Rol A, Romme J, Rosell A, Font M, Sallent S, Sacca D, Sampaio V, Sanchez N, Sanchez B, Santos D, Santos T, Sartim A, Sastry A, Sawka A, Schultz N, Seamark C, Seamark D, Septer-Bijleveld E, Serrano R, Shann F, Sharma K, Shave M, Shen L, Sidaway-Lee K, Baena A, Silva R, Silva J, Silva E, Simão M, Singh R, Siqueira M, Chaves M, Sondag T, Sooriyarachchi E, Sousa A, Spry L, Statton S, Steer A, Santos D, Sterling K, Steve L, Stevens L, Stevens N, Stewart C, Stiglmayer L, Stooper L, Studham J, Subbarao K, Sudbury E, Suiker A, Symons L, Taks E, Tan N, Meireles B, Riele M, Oever J, Lima G, Heine R, Angelo J, Thomson H, Toh R, Trindade A, Tripp H, Tristán E, Troeman D, Truelove A, Tsuha D, Uffing M, Val F, Valero O, Valls E, van Ven C, Van Heuvel L, van Veen S, van Waal M, van Leusen J, van Mook L, van Onzenoort H, van Opdorp M, van Rijen M, van Sluis N, Vasconcelos A, Vega N, Velagapudi S, Vennells L, Venton T, Verheij H, Verhoeven P, Ramos C, Silva P, Vidal S, Vieira P, Oliveira M, Ortega R, Villanueva P, Villar R, Vlahos A, Wadia U, Walker M, Wall K, Wallace R, Waring J, Warren R, Warris A, Watts E, Wearing-Smith M, Webber-Rookes D, Wedderburn J, Wee-Hee A, Wesselingh S, Teo J, Whale B, Williams P, Wolters B, Wood N, Xie I, Younes A, Young A, Batista F, Zhou C, Zwart V, Goodchild L. BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial). BMJ Open 2021, 11: e052101. PMID: 34711598, PMCID: PMC8557250, DOI: 10.1136/bmjopen-2021-052101.Peer-Reviewed Original ResearchConceptsBCG vaccinationHealthcare workersSARS-CoV-2 infectionCOVID-19Multicentre phase IIISevere COVID-19Episodes of illnessPeer-reviewed open access journalsSARS-CoV-2Respiratory illnessSafety profileClinical detailsWork absenteeismImmune responseBlood samplesVaccinationImmune systemInexpensive interventionSecondary objectiveUnrelated pathogensPhase IIIOff-target effectsImmunological analysisIllnessGovernance approvalAnti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves
Santos E, Silva-Filho S, Santos Radai J, Arena A, Fraga T, Lima Cardoso C, Croda J, Leite Kassuya C. Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves. Journal Of Ethnopharmacology 2021, 278: 114308. PMID: 34102271, DOI: 10.1016/j.jep.2021.114308.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesMethylthiazolyldiphenyl-tetrazolium bromideComplete Freund's adjuvantAnti-inflammatory featuresEthanolic extractLong-term treatmentBacillus Calmette-GuerinInflammatory evaluationInflammatory parametersConventional medicationsDaily administrationNeutrophil activityPersistent inflammationRheumatic diseasesFreund's adjuvantInflammatory aspectsPleurisy modelTraditional folk medicineSwiss miceCalmette-GuerinInflammatory diseasesC57BL6 miceVivo modelExperimental modelAdverse effects