2024
Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial
dos Santos P, Messina N, de Oliveira R, da Silva P, Puga M, Dalcolmo M, dos Santos G, de Lacerda M, Jardim B, de Almeida e Val F, Curtis N, Andrews J, Croda J. Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial. The Lancet Infectious Diseases 2024, 24: 594-601. PMID: 38423021, PMCID: PMC11111441, DOI: 10.1016/s1473-3099(23)00818-6.Peer-Reviewed Original ResearchConceptsQuantiFERON-TB GoldPlacebo groupEffect of BCG vaccinationBCG vaccinationBCG groupBCG-DenmarkHealth-care workersNegative baseline resultsMonths of treatmentMycobacterium tuberculosis infectionAdult pulmonary tuberculosisQuantiFERON-TBMedian ageRandomised controlled trialsPulmonary tuberculosisNo significant differenceEfficacy outcomesTuberculosis infectionClinical trialsControlled trialsEffect of vaccinationTreatment drugsTuberculosis preventionSubstudySignificant difference
2020
Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial.
Dias de Oliveira R, da Silva Santos A, Reis C, de Cássia Leite A, Correia Sacchi F, de Araujo R, Dos Santos P, Rolla V, Martinez L, Andrews J, Croda J. Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial. American Journal Of Tropical Medicine And Hygiene 2020, 103: 1466-1472. PMID: 32876010, PMCID: PMC7543866, DOI: 10.4269/ajtmh.20-0110.Peer-Reviewed Original ResearchConceptsQFT conversionTB infectionSecondary outcomesPlacebo-controlled trialQuantiFERON-TB GoldFuture clinical trialsPrimary prophylaxisMiddle-income countriesPrimary outcomeTuberculosis infectionIntervention armTuberculosis incidenceControl armTrial protocolClinical trialsElevated riskInterim analysisLatent infectionCutoff pointInfectionTrialsHigher cutoffSustained conversionInternational unitsLower ratesA summary of the proceedings of a meeting on the treatment of latent tuberculosis infection in target populations in Brazil
Rolla V, Trajman A, Kawamura M, Cavalcante S, Soares E, Perini F, Carvalho A, Croda J, Silva J, Schmaltz C, Sant'Anna F, Bastos M, Gomes A, Durovni B, Saraceni V, Silva E, Mello F, Santos M, Pinto M. A summary of the proceedings of a meeting on the treatment of latent tuberculosis infection in target populations in Brazil. Jornal Brasileiro De Pneumologia 2020, 46: e20200023. PMID: 32696834, PMCID: PMC7567628, DOI: 10.36416/1806-3756/e20200023.Peer-Reviewed Original Research
2019
Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required
Puga M, Bandeira L, Pompilio M, de Rezende G, Soares L, de Castro V, Tanaka T, Cesar G, de Oliveira S, Teles S, Yassuda R, dos Santos Weis-Torres S, Basílio S, Croda J, Motta-Castro A. Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required. PLOS ONE 2019, 14: e0221265. PMID: 31437184, PMCID: PMC6705821, DOI: 10.1371/journal.pone.0221265.Peer-Reviewed Original ResearchConceptsHepatitis B virusSyphilis infectionViral hepatitisHIV infectionB virusAnti-HCV positive samplesChronic hepatitis B virusFirst-line anti-tuberculosis drugsLifetime syphilis infectionCases of tuberculosisAnti-TB drugsCross-sectional studyPublic health problemAnti-tuberculosis drugsCurrent HCVHCV exposureHCV RNAHepatitis testingTuberculosis infectionActive syphilisSerological markersEpidemiological featuresFrequent causeSide effectsHCVPaediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies
Martinez L, Lo N, Cords O, Hill P, Khan P, Hatherill M, Mandalakas A, Kay A, Croda J, Horsburgh C, Zar H, Andrews J. Paediatric tuberculosis transmission outside the household: challenging historical paradigms to inform future public health strategies. The Lancet Respiratory Medicine 2019, 7: 544-552. PMID: 31078497, PMCID: PMC7323920, DOI: 10.1016/s2213-2600(19)30137-7.Peer-Reviewed Original ResearchConceptsM tuberculosis transmissionHousehold contact tracingTuberculosis transmissionFuture public health strategiesContact tracingGlobal tuberculosis control effortsAdult tuberculosis casesPaediatric tuberculosis infectionMycobacterium tuberculosis transmissionHigh-burden settingsTuberculosis control effortsEffective public health responsePopulation attributable fractionPublic health strategiesAge 5 yearsCommunity-based interventionsPublic health interventionsPublic health responsePediatric transmissionChildhood tuberculosisTuberculosis infectionTuberculosis casesActive surveillanceHealth strategiesHousehold exposure
2018
Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Warsinske H, Rao A, Moreira F, Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response. JAMA Network Open 2018, 1: e183779. PMID: 30646264, PMCID: PMC6324428, DOI: 10.1001/jamanetworkopen.2018.3779.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsBrazilChildCohort StudiesDisease ProgressionFemaleGenes, BacterialGenetic MarkersHumansLatent TuberculosisMaleMiddle AgedMolecular TypingMycobacterium tuberculosisReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, BacterialSeverity of Illness IndexTuberculosisYoung AdultConceptsTB scoreAdolescent cohort studyNegative predictive valueTreatment responseTB diseaseCohort studyTuberculosis infectionTriage testPositron emission tomography-computed tomography scanPredictive valueLatent M tuberculosis infectionLatent Mycobacterium tuberculosis infectionPrimary health care clinicsHigh negative predictive valueCulture-positive adultsM tuberculosis infectionWhole bloodMycobacterium tuberculosis infectionEnd of treatmentHealth care clinicsCase-control studyIndependent prospective cohortsDiagnosis of tuberculosisSlower treatment responseCase-control cohort
2017
Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
Bosch L, Bosch B, De Boeck K, Nawrot T, Meyts I, Vanneste D, Le Bourlegat C, Croda J, da Silva Filho L. Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory. BMC Infectious Diseases 2017, 17: 340. PMID: 28499359, PMCID: PMC5429554, DOI: 10.1186/s12879-017-2448-z.Peer-Reviewed Original ResearchConceptsCystic fibrosisCommon fatal genetic diseaseMellitus type 2Mycobacterium tuberculosis infectionAIDS incidence ratesTuberculosis infectionTB incidenceMtb infectionTuberculosis incidenceIncidence rateSmoking dataType 2Fatal genetic diseaseRelative protectionCF carriersConfoundersMonthly incomeInfectionIncidenceNegative correlationSpatial epidemiologyGenetic diseasesFibrosisEvolutionary selective advantageTuberculosis
2016
Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners
Paião DS, Lemos EF, Carbone AD, Sgarbi RV, Junior AL, da Silva FM, Brandão LM, dos Santos LS, Martins VS, Simionatto S, Motta-Castro AR, Pompílio MA, Urrego J, Ko AI, Andrews JR, Croda J. Impact of mass-screening on tuberculosis incidence in a prospective cohort of Brazilian prisoners. BMC Infectious Diseases 2016, 16: 533. PMID: 27716170, PMCID: PMC5048439, DOI: 10.1186/s12879-016-1868-5.Peer-Reviewed Original ResearchConceptsTuberculin skin testingActive tuberculosisRisk factorsSubsequent diseaseProspective cohort studyEarly case detectionHigh transmission settingsHigh-risk populationPotential risk factorsProportional hazards modelSubsequent disease riskMass screening interventionTST conversionCohort studyProspective cohortHIV testingTuberculosis infectionScreening interventionsSkin testingTB notificationsTuberculosis incidenceSubsequent riskCase detectionSputum samplesActive screening
2015
Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study
Carbone Ada S, Paião DS, Sgarbi RV, Lemos EF, Cazanti RF, Ota MM, Junior AL, Bampi JV, Elias VP, Simionatto S, Motta-Castro AR, Pompílio MA, de Oliveira SM, Ko AI, Andrews JR, Croda J. Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study. BMC Infectious Diseases 2015, 15: 24. PMID: 25608746, PMCID: PMC4307675, DOI: 10.1186/s12879-015-0764-8.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionPrevalence of LTBITuberculin skin testActive TBLTBI prevalenceWeeks of symptomsHigh transmission settingsCross-sectional studyPopulation-based samplePoisson regression modelsDuration of incarcerationHierarchical Poisson regression modelActive diseaseTB infectionLatent tuberculosisTB casesHIV testingSputum cultureTuberculosis infectionPoint prevalenceSkin testTuberculosis incidenceRisk factorsMultivariable modelSputum samples
2013
Active and latent tuberculosis in prisoners in the Central-West Region of Brazil
Estevan A, de Oliveira S, Croda J. Active and latent tuberculosis in prisoners in the Central-West Region of Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2013, 46: 515-518. PMID: 23904084, DOI: 10.1590/0037-8682-1441-2013.Peer-Reviewed Original ResearchSugar cane manufacturing is associated with tuberculosis in an indigenous population in Brazil
Sacchi FP, Croda MG, Estevan AO, Ko AI, Croda J. Sugar cane manufacturing is associated with tuberculosis in an indigenous population in Brazil. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2013, 107: 152-157. PMID: 23306443, DOI: 10.1093/trstmh/trs089.Peer-Reviewed Original ResearchConceptsCause of morbidityCase-control studySpecific epidemiological conditionsTB contactTB infectionTuberculosis infectionAnnual incidenceTuberculosis casesMale genderRisk factorsDisease surveillance programsMultivariate analysisTuberculosisDisease controlSurveillance programControl casesIndigenous populationsEpidemiological conditionsInfectionPotential relationshipPopulationNational disease surveillance programmeMorbidityMortalityIncidence