2021
Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis
Moreira F, Radai J, de Souza V, Berno C, de Araújo F, Andrade-Silva M, Oliveira R, Arena A, de Oliveira Henriques M, Kassuya C, Croda J. Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis. Phytomedicine Plus 2021, 1: 100117. DOI: 10.1016/j.phyplu.2021.100117.Peer-Reviewed Original ResearchInflammatory responseOral treatmentSplenic phagocytosisTumor necrosis factor levelsAnti-inflammatory actionNecrosis factor levelsAcute oral toxicity testAnti-inflammatory propertiesMycobacterium bovisMycobacterium tuberculosis strainsDifferential leukocyte countsOral toxicity testPleurisy inductionCytokine productionPleurisy modelLeukocyte countMinimum inhibitory concentrationMycobacteria infectionMycobacteria viabilityPleural exudatesLeukocyte migrationTuberculosis strainsVivo modelToxicity signsFactor levels
2020
Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice
Kassuya R, Radai J, Macorini L, Nunes V, Salvador M, Leite P, Oliveira R, Croda J, Arena A, Kassuya C. Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice. Inflammopharmacology 2020, 29: 439-450. PMID: 32910315, DOI: 10.1007/s10787-020-00752-0.Peer-Reviewed Original ResearchMeSH KeywordsAmaranthaceaeAnimalsAnti-Inflammatory AgentsAntitubercular AgentsCarrageenanDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLMicrobial Sensitivity TestsMycobacterium tuberculosisPlant ExtractsPleurisyRatsRats, WistarConceptsSwiss miceIL-1β levelsC57BL-6 miceEthanolic extractInflammation/infectionSafe new drugsM. tuberculosis growthMechanical hyperalgesiaInflammatory parametersOral treatmentIL-1βPleurisy modelMinimum inhibitory concentrationPharmacoeconomic perspectiveC57BL6 miceComplete adjuvantSubcutaneous injectionOral administrationWistar ratsMiceMycobacterium tuberculosisNew drugsHealth benefitsTuberculosis growthInhibitory concentration
2014
Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, α-phellandrene, and essential oil from Schinus terebinthifolius fruits in a neuropathic pain model
Piccinelli A, Santos J, Konkiewitz E, Oesterreich S, Formagio A, Croda J, Ziff E, Kassuya C. Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, α-phellandrene, and essential oil from Schinus terebinthifolius fruits in a neuropathic pain model. Nutritional Neuroscience 2014, 18: 217-224. PMID: 24661285, DOI: 10.1179/1476830514y.0000000119.Peer-Reviewed Original ResearchConceptsCold hyperalgesiaMechanical hyperalgesiaAntidepressive actionOral treatmentLocomotor activityExhibit anti-inflammatory activityNerve injury modelNeuropathic pain modelDepressive-like behaviorDose of ketamineAnti-inflammatory activityOpen field testAntihyperalgesic effectNeuropathic painSNI ratsPain modelSwim testS. terebinthifolius fruitsInjury modelOral administrationHyperalgesiaSchinus terebinthifolius fruitsCold stimuliRatsTreatment