2023
Spread of Mycobacterium tuberculosis in Southern Brazilian persons deprived of liberty: a molecular epidemiology study
Busatto C, Possuelo L, Bierhals D, de Oliveira C, de Souza M, Fanfa D, Barreto É, Schwarzbold P, Von Groll A, Portugal I, Perdigão J, Croda J, Andrews J, da Silva P, Ramis I. Spread of Mycobacterium tuberculosis in Southern Brazilian persons deprived of liberty: a molecular epidemiology study. European Journal Of Clinical Microbiology & Infectious Diseases 2023, 42: 297-304. PMID: 36701032, DOI: 10.1007/s10096-023-04546-4.Peer-Reviewed Original ResearchConceptsAnti-TB drug resistanceM. tuberculosisTB control programsCross-sectional studyM. tuberculosis strainsMolecular epidemiology studiesTB burdenLAM strainsTuberculosis strainsEpidemiology studiesDrug resistanceMycobacterium tuberculosisCentral laboratoryTranslational researchTuberculosisCommon strainControl programsPDLMolecular characterizationHaarlemImproved strategiesPersonsPhylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay
Sanabria G, Sequera G, Aguirre S, Méndez J, dos Santos P, Gustafson N, Godoy M, Ortiz A, Cespedes C, Martínez G, García-Basteiro A, Andrews J, Croda J, Walter K. Phylogeography and transmission of Mycobacterium tuberculosis spanning prisons and surrounding communities in Paraguay. Nature Communications 2023, 14: 303. PMID: 36658111, PMCID: PMC9849832, DOI: 10.1038/s41467-023-35813-9.Peer-Reviewed Original ResearchConceptsIncident tuberculosis casesTB control programsTuberculosis casesRecent transmissionTransmission clustersNew infectionsProspective genomic surveillanceTransmission riskM. tuberculosisMycobacterium tuberculosisGenomic surveillanceMycobacterium tuberculosis complex genomeTuberculosisOutside prisonTransmission linkageControl programsInfectionIncidence
2020
Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice
Kassuya R, Radai J, Macorini L, Nunes V, Salvador M, Leite P, Oliveira R, Croda J, Arena A, Kassuya C. Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice. Inflammopharmacology 2020, 29: 439-450. PMID: 32910315, DOI: 10.1007/s10787-020-00752-0.Peer-Reviewed Original ResearchMeSH KeywordsAmaranthaceaeAnimalsAnti-Inflammatory AgentsAntitubercular AgentsCarrageenanDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLMicrobial Sensitivity TestsMycobacterium tuberculosisPlant ExtractsPleurisyRatsRats, WistarConceptsSwiss miceIL-1β levelsC57BL-6 miceEthanolic extractInflammation/infectionSafe new drugsM. tuberculosis growthMechanical hyperalgesiaInflammatory parametersOral treatmentIL-1βPleurisy modelMinimum inhibitory concentrationPharmacoeconomic perspectiveC57BL6 miceComplete adjuvantSubcutaneous injectionOral administrationWistar ratsMiceMycobacterium tuberculosisNew drugsHealth benefitsTuberculosis growthInhibitory concentration
2019
A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols
de Sousa N, Sandström N, Shen L, Håkansson K, Vezozzo R, Udekwu K, Croda J, Rothfuchs A. A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols. Tuberculosis 2019, 120: 101896. PMID: 32090857, PMCID: PMC7049907, DOI: 10.1016/j.tube.2019.101896.Peer-Reviewed Original ResearchConceptsTB hotspotsM. tuberculosisActive pulmonary diseaseAirborne M. tuberculosisElectrostatic air samplerInhalation of aerosolsViable Mycobacterium tuberculosisPulmonary diseaseTB controlTB transmissionM. bovis BCGTuberculosisInfectious diseasesMycobacterium tuberculosisBovis BCGTuberculosis detectionMore human livesMolecular signaturesDiseaseCoughPatientsWorld populationInhalationBCGImportant roleGenetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
Tatara M, Perdigão J, Viveiros M, Kritski A, Silva K, Sacchi F, de Lima C, Dos Santos P, Diniz J, Almeida Silva P, Gomes P, Gomes M, Cunha E, Lapa E Silva J, Portugal I, Croda J, Andrade M. Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil. American Journal Of Tropical Medicine And Hygiene 2019, 101: 774-779. PMID: 31392954, PMCID: PMC6779181, DOI: 10.4269/ajtmh.19-0324.Peer-Reviewed Original ResearchConceptsPopulation-based prospective studyDrug resistanceMolecular epidemiologyResistance profilesRepetitive units-variable numberMTB/RIFDrug susceptibility testDrug resistance profilesTransmission of MtbPublic health policyPhenotypic resistance profilesIsoniazid monoTB preventionProspective studyNew strain typesTB epidemiologyPrimary resistanceHigh prevalenceMTB isolatesProportion methodHealth policyMycobacterium tuberculosisSusceptibility testsTuberculosisVulnerable populationsDetection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications
Martinez L, Verma R, Croda J, Horsburgh C, Walter K, Degner N, Middelkoop K, Koch A, Hermans S, Warner D, Wood R, Cobelens F, Andrews J. Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications. European Respiratory Journal 2019, 53: 1802302. PMID: 31048345, PMCID: PMC6753378, DOI: 10.1183/13993003.02302-2018.Peer-Reviewed Original ResearchConceptsInfectious tuberculosis patientsTuberculosis patientsTB transmissionCongregate settingsMouse modelGuinea pigsInfectious threatsMycobacterium tuberculosisDroplet nucleiConsistent findingScientific evidenceInfectious potentialEpidemiological implicationsPrimary routeFurther investigationSeminal experimental studiesRecent studiesHuman sourcesEvidencePatientsTuberculosisFindingsStudyInfectiousnessViability
2017
Anti-inflammatory, antimycobacterial and genotoxic evaluation of Doliocarpus dentatus
Ishikawa R, Leitão M, Kassuya R, Macorini L, Moreira F, Cardoso C, Coelho R, Pott A, Gelfuso G, Croda J, Oliveira R, Kassuya C. Anti-inflammatory, antimycobacterial and genotoxic evaluation of Doliocarpus dentatus. Journal Of Ethnopharmacology 2017, 204: 18-25. PMID: 28392458, DOI: 10.1016/j.jep.2017.04.004.Peer-Reviewed Original ResearchConceptsMinimal inhibitory concentrationDoliocarpus dentatusPeripheral leukocyte countAnti-inflammatory agentsMechanical hypersensitivityUrine retentionCarrageenan modelLeukocyte countOral administrationLeukocyte migrationInflammation processPhagocytic activityPhagocytosis testMycobacterium tuberculosisMicronucleus testSignificant decreaseEthanolic extractGenotoxic aspectsGenotoxic evaluationInhibitory concentrationAntimycobacterial activitySafe useBetulinic acidMagnetic resonanceCount
2016
Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk.
Trevizan L, do Nascimento K, Santos J, Kassuya C, Cardoso C, do Carmo Vieira M, Moreira F, Croda J, Formagio A. Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk. Journal Of Ethnopharmacology 2016, 192: 510-515. PMID: 27612433, DOI: 10.1016/j.jep.2016.08.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsAntioxidantsAntitubercular AgentsBenzothiazolesBiphenyl CompoundsCarrageenanChemotaxis, LeukocyteDexamethasoneDisease Models, AnimalDose-Response Relationship, DrugEdemaFemaleGas Chromatography-Mass SpectrometryMaleMiceMycobacterium tuberculosisOils, VolatilePhytotherapyPicratesPlant ExtractsPlant LeavesPlant OilsPlants, MedicinalPleurisySapindaceaeSulfonic AcidsTerpenesTime FactorsConceptsNatural anti-inflammatory agentAnti-inflammatory agentsSubcutaneous injectionOral administrationAnti-Mycobacterium tuberculosis activityAnti-mycobacterial activityAntioxidant activityTotal leucocytesEOAETuberculosis activityMycobacterium tuberculosisGas chromatography-mass spectrometrySignificant inhibitionMiceTraditional medicineEdemaPleurisyPositive controlReference standardDexamethasoneCarrageenanAdministrationModerate antioxidant activityInjectionMajor constituents