Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Borba M, Val F, Sampaio V, Alexandre M, Melo G, Brito M, Mourão M, Brito-Sousa J, Baía-da-Silva D, Guerra M, Hajjar L, Pinto R, Balieiro A, Pacheco A, Santos J, Naveca F, Xavier M, Siqueira A, Schwarzbold A, Croda J, Nogueira M, Romero G, Bassat Q, Fontes C, Albuquerque B, Daniel-Ribeiro C, Monteiro W, Lacerda M. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open 2020, 3: e208857. PMID: 32330277, DOI: 10.1001/jamanetworkopen.2020.8857.Peer-Reviewed Original ResearchConceptsHigh dosage groupSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionLow dosage groupSyndrome coronavirus 2 infectionCoronavirus 2 infectionChloroquine diphosphateDay 13COVID-19Phase IIb clinical trialNonsevere COVID-19Secondary end pointsSevere COVID-19High-dose groupSpecific antiviral therapyTertiary care facilityIIb clinical trialCoronavirus disease 2019More heart diseaseParticipants' clinical statusAdjunctive therapyAdult patientsIll patientsPrimary outcomeAntiviral therapyCOVID-19 in Brazil: advantages of a socialized unified health system and preparation to contain cases
Croda J, de Oliveira W, Frutuoso R, Mandetta L, Baia-da-Silva D, Brito-Sousa J, Monteiro W, Lacerda M. COVID-19 in Brazil: advantages of a socialized unified health system and preparation to contain cases. Revista Da Sociedade Brasileira De Medicina Tropical 2020, 53: e20200167. PMID: 32320998, PMCID: PMC7182282, DOI: 10.1590/0037-8682-0167-2020.Peer-Reviewed Original ResearchConceptsCoronavirus disease 2019New coronavirus disease 2019Public health emergencyWorld Health OrganizationCOVID-19 casesUnified Health SystemDisease 2019First COVID-19 caseSevere casesHealth systemHealth OrganizationHealth emergencyCOVID-19First caseFuture studiesInternational concernEarly preparation