2022
Physician Graded Toxicity Profiles and Survival Outcomes among Patients with Non-Metastatic Oropharyngeal Carcinoma Treated with Proton Therapy vs. Intensity-Modulated Radiation Therapy
Youssef I, Yoon J, Zakeri K, Cohen M, Wong R, Yu Y, Kang J, Gelblum D, McBride S, Sherman E, Dunn L, Cracchiolo J, Chen L, Lee N. Physician Graded Toxicity Profiles and Survival Outcomes among Patients with Non-Metastatic Oropharyngeal Carcinoma Treated with Proton Therapy vs. Intensity-Modulated Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: e325-e326. DOI: 10.1016/j.ijrobp.2022.07.1399.Peer-Reviewed Original ResearchProgression-free survivalIntensity-modulated radiation therapyOropharyngeal carcinomaAcute gradeIMRT groupLocoregional recurrenceOncologic outcomesAdverse eventsOverall survivalRadiation therapyPT groupSignificant differencesTreatment-related adverse eventsPatient/tumor characteristicsProton therapyCurative-intent radiationGrade 3 dysphagiaPresence of xerostomiaMedian RT doseRetrospective cohort studyProspective Randomized ComparisonPatient-reported outcomesSimilar oncologic outcomesMATERIAL/METHODSReduction of doseOutcomes and Toxicities of Nonmedullary Thyroid Tumors Treated with Proton Beam Radiation Therapy
Youssef I, Yoon J, Mohamed N, Zakeri K, Press R, Yu Y, Kang J, Wong R, Tuttle R, Shaha A, Sherman E, Lee N. Outcomes and Toxicities of Nonmedullary Thyroid Tumors Treated with Proton Beam Radiation Therapy. International Journal Of Particle Therapy 2022, 9: 20-30. PMID: 36060412, PMCID: PMC9415751, DOI: 10.14338/ijpt-22-00005.1.Peer-Reviewed Original ResearchPercent of patientsLocal-regional recurrenceThyroid cancerRadiation therapyGross diseaseOverall survivalPercutaneous endoscopic gastrostomy tubeProton therapyProton beam radiation therapyAcute grade 3Central neck compartmentFavorable therapeutic ratioIntensity-modulated radiation therapyBeam radiation therapyProton beam therapyConcurrent chemotherapyPalliative radiationUnresectable diseaseAdjuvant radiationDefinitive radiationT4 diseaseMetastatic diseaseNeck compartmentRegional recurrenceUpper mediastinum
2021
Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy
Li X, Kitpanit S, Lee A, Mah D, Sine K, Sherman EJ, Dunn LA, Michel LS, Fetten J, Zakeri K, Yu Y, Chen L, Kang JJ, Gelblum DY, McBride SM, Tsai CJ, Riaz N, Lee NY. Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy. JAMA Network Open 2021, 4: e2113205. PMID: 34143193, PMCID: PMC8214161, DOI: 10.1001/jamanetworkopen.2021.13205.Peer-Reviewed Original ResearchConceptsLocoregional failure-free survivalNonmetastatic nasopharyngeal carcinomaProgression-free survivalIntensity-modulated radiation therapyIntensity-modulated proton therapyCurative-intent radiotherapyIMPT groupIMRT groupAdverse eventsOncologic outcomesOverall survivalSurvival outcomesNasopharyngeal carcinomaMAIN OUTCOMERadiation therapyToxicity profileHigher acute adverse eventsSimilar progression-free survivalTertiary academic cancer centerTreatment-related adverse eventsPropensity score-matched analysisTreatment-related toxic effectsMultivariable logistic regression analysisPoor progression-free survivalChronic grade 3
2018
Whole Versus Partial Bladder Radiation
Kang J, Steinberg M, Kupelian P, Alexander S, King C. Whole Versus Partial Bladder Radiation. American Journal Of Clinical Oncology 2018, 41: 107-114. PMID: 26535994, DOI: 10.1097/coc.0000000000000237.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinoma, Transitional CellCohort StudiesDisease-Free SurvivalFemaleGeriatric AssessmentHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingOrgan Sparing TreatmentsPrognosisRadiation Dose HypofractionationRadiation InjuriesRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeUnited StatesUrinary Bladder NeoplasmsConceptsOverall survivalLymph nodesWhole bladderLocal controlMuscle-invasive bladder cancerMuscle-invasive recurrenceMulti-institutional cohortSimultaneous integrated boostIntensity-modulated radiation therapyDefinitive chemoradiationPrimary endpointSecondary endpointsBladder treatmentLocal recurrenceUrothelial cancerMean ageBladder cancerIntegrated boostInstitutional experienceRetrospective analysisBladder wallBoost volumeRadiation therapySimilar survivalTherapeutic ratio