2009
Analysis of gene expression in PTHrP−/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis
Hens J, Dann P, Hiremath M, Pan T, Chodosh L, Wysolmerski J. Analysis of gene expression in PTHrP−/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis. Developmental Dynamics 2009, 238: 2713-2724. PMID: 19795511, PMCID: PMC2862621, DOI: 10.1002/dvdy.22097.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 4Cells, CulturedDipeptidesDown-RegulationGene Expression Regulation, DevelopmentalHydroxamic AcidsIntercellular Signaling Peptides and ProteinsKeratinsMammary Glands, AnimalMatrix Metalloproteinase 2Matrix Metalloproteinase InhibitorsMesodermMiceMice, KnockoutMorphogenesisOligonucleotide Array Sequence AnalysisParathyroid Hormone-Related ProteinProtease InhibitorsSignal TransductionTranscription FactorsUp-RegulationConceptsGene expressionMammary budMammary mesenchymeDuctal outgrowthMesenchymal cellsEmbryonic mammary developmentMMP2 gene expressionEmbryonic mammary budFunctional roleGenesDuctal morphogenesisBud culturesMammary developmentBudsPTHrP effectsBMPMesenchymeExpressionMMP2 activityMMP2OutgrowthVentral skinCellsMorphogenesisBMP4
2005
Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary gland
Hens JR, Wysolmerski JJ. Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary gland. Breast Cancer Research 2005, 7: 220. PMID: 16168142, PMCID: PMC1242158, DOI: 10.1186/bcr1306.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMammary gland developmentEmbryonic mammary glandGland developmentMolecular mechanismsEmbryonic mammary gland developmentMammary glandProtein signalingMore genesFibroblast growth factorSignaling pathwaysFunctional roleGrowth factorWntGenesKey stagesSignalingMesenchymePathwayMechanismGlandEpidermisDevelopment
2000
Introduction of the human growth hormone gene into the guinea pig mammary gland by in vivo transfection promotes sustained expression of human growth hormone in the milk throughout lactation
Hens J, Amstutz M, Schanbacher F, Mather I. Introduction of the human growth hormone gene into the guinea pig mammary gland by in vivo transfection promotes sustained expression of human growth hormone in the milk throughout lactation. Biochimica Et Biophysica Acta 2000, 1523: 161-171. PMID: 11042380, DOI: 10.1016/s0304-4165(00)00117-3.Peer-Reviewed Original ResearchConceptsHuman growth hormone geneGrowth hormone geneGuinea-pig mammary glandPig mammary glandHormone geneBovine mammary cellsTransfection of cellsMammary glandGene promoterBiological roleRecombinant proteinsTransgenic animalsExpression plasmidMammary cellsHuman growth hormoneCytomegalovirus promoterTransfectionSustained expressionGenesPromoterGrowth hormonePlasmid DNAMammary tissueExpressionTransfection complexes