2021
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Cui C, Wang J, Fagerberg E, Chen PM, Connolly KA, Damo M, Cheung JF, Mao T, Askari AS, Chen S, Fitzgerald B, Foster GG, Eisenbarth SC, Zhao H, Craft J, Joshi NS. Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. Cell 2021, 184: 6101-6118.e13. PMID: 34852236, PMCID: PMC8671355, DOI: 10.1016/j.cell.2021.11.007.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorHumansInterleukinsLung NeoplasmsMiceMice, Inbred C57BLMice, KnockoutConceptsCD8 TB cellsTfh cellsLung adenocarcinomaTfh-B cell interactionsTumor-specific B cellsFollicular helper cellsAnti-tumor immunityB cell signaturesCell effector functionsGerminal center formationGC B cellsCD4 THelper cellsTumor controlTumor neoantigensEffector functionsCell collaborationCell responsesCell signatureTumor cellsSignature correlatesNeoantigensCell functionCD4Priming of myelin-specific T cells in the absence of dendritic cells results in accelerated development of Experimental Autoimmune Encephalomyelitis
Luu T, Cheung JF, Baccon J, Waldner H. Priming of myelin-specific T cells in the absence of dendritic cells results in accelerated development of Experimental Autoimmune Encephalomyelitis. PLOS ONE 2021, 16: e0250340. PMID: 33891644, PMCID: PMC8064509, DOI: 10.1371/journal.pone.0250340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensCD4-Positive T-LymphocytesCells, CulturedDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalMiceMice, Inbred C57BLMice, TransgenicMyelin SheathConceptsExperimental autoimmune encephalomyelitisT cell responsesDendritic cellsT cellsMultiple sclerosisCell responsesAutoimmune encephalomyelitisSJL miceProteolipid proteinPro-inflammatory T cell responsesAbsence of DCsImportance of DCsPLP-specific T cellsSpontaneous experimental autoimmune encephalomyelitisMyelin-specific T cellsSelf-reactive T cellsSevere experimental autoimmune encephalomyelitisDendritic cells resultsSelf-reactive CD4Myelin antigensCNS antigensInflammatory CD4Autoimmune diseasesDC deficiencyAnimal models
2020
Inducible de novo expression of neoantigens in tumor cells and mice
Damo M, Fitzgerald B, Lu Y, Nader M, William I, Cheung JF, Connolly KA, Foster GG, Akama-Garren E, Lee DY, Chang GP, Gocheva V, Schmidt LM, Boileve A, Wilson JH, Cui C, Monroy I, Gokare P, Cabeceiras P, Jacks T, Joshi NS. Inducible de novo expression of neoantigens in tumor cells and mice. Nature Biotechnology 2020, 39: 64-73. PMID: 32719479, PMCID: PMC7854852, DOI: 10.1038/s41587-020-0613-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, NeoplasmCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell EngineeringFemaleHumansMiceOrgan SpecificityRNA SplicingTumor Cells, CulturedConceptsT cell responsesLevel of regulationRNA splicingDNA recombinationGenetic regulationTolerance mechanismsInducible expressionNeoantigen expressionCell responsesNaïve T-cell responsesCD4 T cell responsesTumor cell linesPeripheral tolerance mechanismsT cell toleranceCentral T cell toleranceCell linesExpressionNovo expressionTight controlEndogenous CD8Antitumor immunityPeripheral toleranceAutoimmune diseasesT cellsThymus results