2014
Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production
Boras-Granic K, Dann P, VanHouten J, Karaplis A, Wysolmerski J. Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production. PLOS ONE 2014, 9: e90418. PMID: 24785493, PMCID: PMC4006745, DOI: 10.1371/journal.pone.0090418.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersFemaleGene DeletionGene Expression Regulation, DevelopmentalMammary Glands, AnimalMiceMice, TransgenicNuclear Localization SignalsParathyroid Hormone-Related ProteinPeptide FragmentsProtein Interaction Domains and MotifsSex CharacteristicsConceptsMammary gland developmentType 1 PTH/PTHrP receptorC-terminusEmbryonic mammary gland developmentPTH/PTHrP receptorGland developmentPTHrP mRNA levelsNuclear localization signalNuclear localization sequenceHormone-related proteinEmbryonic mammary developmentMammary epithelial cellsLocalization signalNuclear functionsPTHrP productionPTHrP receptorAlternative animal modelLocalization sequencePTHR1 geneAnimal modelsEndocrine fashionMutant formsPTHrPDevelopmental defectsMesenchyme differentiation
2001
Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes
Dunbar ME, Dann P, Brown CW, Van Houton J, Dreyer B, Philbrick WP, Wysolmerski JJ. Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes. Journal Of Endocrinology 2001, 171: 403-416. PMID: 11739006, DOI: 10.1677/joe.0.1710403.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell DivisionEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalMammary Glands, AnimalMiceMice, TransgenicMorphogenesisParathyroid Hormone-Related ProteinPhenotypeProteinsTetracyclineConceptsParathyroid hormone-related proteinHormone-related proteinPTHrP overexpressionMammary glandLobuloalveolar developmentDuctal elongationMammary developmentOverexpression of PTHrPDouble transgenic miceTransgenic mice resultsTerminal end budsEpithelial cell apoptosisPubertal phenotypesDuctal branchingEmbryonic mammary developmentTransgenic miceMice resultsPTHrPEnd budsDecrease apoptosisCell apoptosisBasal rateDuctal morphogenesisCell proliferationDuctal tree