2002
Midtrimester nuchal thickness and the prediction of postnatal congenital heart defect
Bahado-Singh RO, Rowther M, Bailey J, Copel J, Mendilcioglu I, Choi S, Oz U. Midtrimester nuchal thickness and the prediction of postnatal congenital heart defect. American Journal Of Obstetrics And Gynecology 2002, 187: 1250-1253. PMID: 12439514, DOI: 10.1067/mob.2002.128025.Peer-Reviewed Original ResearchConceptsNuchal thickness measurementPrediction of CHDNuchal thicknessRisk factorsHeart defectsStepwise logistic regression analysisBackground population riskIndividual patient's riskEpidemiologic risk factorsSignificant risk factorsMultiple risk factorsPatient-specific riskSignificant predictorsLogistic regression analysisCongenital heart defectsOnly significant predictorMajor CHDPostnatal evaluationPatient riskMidtrimester fetusesNormal fetusesCongenital heartCHDLogistic regression
2001
Ratio of nuchal thickness to humerus length for Down syndrome detection
Bahado-Singh R, Oz U, Hsu C, Deren O, Copel J, Mahoney M. Ratio of nuchal thickness to humerus length for Down syndrome detection. American Journal Of Obstetrics And Gynecology 2001, 184: 1284-1288. PMID: 11349203, DOI: 10.1067/mob.2001.113878.Peer-Reviewed Original ResearchConceptsDown syndrome riskHigh-risk groupMaternal ageSyndrome riskNuchal thicknessDown syndromeDown syndrome detectionStudy populationIndividual Down's syndrome riskMean gestational ageOverall study populationAge-related riskHumerus lengthSyndrome detectionDown syndrome casesDown's syndrome likelihood ratiosGestational ageProspective dataHealthy groupGross anomaliesNormal fetusesSyndrome casesBiparietal diameterAmniocentesis casesFetal population
1999
Gestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk
Bahado‐Singh R, Oz U, Kovanci E, Deren O, Feather M, Hsu C, Copel J, Mahoney M. Gestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk. The Journal Of Maternal-Fetal Medicine 1999, 8: 37-43. PMID: 10090488, DOI: 10.1002/(sici)1520-6661(199903/04)8:2<37::aid-mfm1>3.0.co;2-p.Peer-Reviewed Original ResearchA high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome risk
1995
Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results
Bahado-Singh R, Goldstein I, Uerpairojkit B, Copel J, Mahoney M, Baumgarten A. Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results. American Journal Of Obstetrics And Gynecology 1995, 173: 1106-1110. PMID: 7485301, DOI: 10.1016/0002-9378(95)91334-3.Peer-Reviewed Original ResearchConceptsAbnormal triple-screen resultsTriple-screen resultsNuchal thicknessDown syndromeHuman chorionic gonadotropin levelsNuchal thickness measurementChorionic gonadotropin levelsReceiver operator characteristic curveNumber of amniocentesesReceiver operator characteristic plotsRisk thresholdMidtrimester pregnancyGonadotropin levelsWeeks' gestationMaternal ageConsecutive fetusesUnconjugated estriolSerum screeningEuploid fetusesAlpha-fetoproteinSyndromeTrisomy 21Screen resultsRisk estimatesFetuses