2020
Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation
Friedman DM, Kim M, Costedoat-Chalumeau N, Clancy R, Copel J, Phoon CK, Cuneo B, Cohen R, Masson M, Wainwright BJ, Zahr N, Saxena A, Izmirly P, Buyon JP. Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation. Circulation Arrhythmia And Electrophysiology 2020, 13: e008686. PMID: 32907357, PMCID: PMC7668319, DOI: 10.1161/circep.120.008686.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsCardiotoxicityDrug Administration ScheduleDrug MonitoringElectrocardiographyFemaleFetal BloodFetal HeartGestational AgeHeart BlockHeart RateHumansHydroxychloroquineInfantInfant, NewbornMalePredictive Value of TestsPregnancyRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsBlood levelsSSA/Ro antibodiesHistorical healthy controlsHydroxychloroquine blood levelsCord blood levelsCongenital heart blockSystemic lupus erythematosusTrimester of pregnancyEfficacy of hydroxychloroquineCoronavirus disease-19Electrocardiographic QT intervalCOVID-19 studiesPostnatal ECGRo antibodiesIndividual pregnanciesLupus erythematosusQTc prolongationAntiviral therapyHeart blockClinical efficacyRheumatic conditionsDrug exposureMaternal useCord bloodDisease-19Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers
Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA, Phoon CKL, Cuneo BF, Cohen RE, Robins K, Masson M, Wainwright BJ, Zahr N, Saxena A, Buyon JP. Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers. Journal Of The American College Of Cardiology 2020, 76: 292-302. PMID: 32674792, PMCID: PMC7394202, DOI: 10.1016/j.jacc.2020.05.045.Peer-Reviewed Original ResearchConceptsCongenital heart blockPrimary outcomeSecondary outcomesEndocardial fibroelastosisHeart blockRecurrence of CHBSSA/Ro-positive mothersAnti-SSA/RoMacrophage Toll-like receptorToll-like receptor antagonistsCutaneous neonatal lupusRo-positive mothersGestational weeks 10Toll-like receptorsFetal cardiac diseaseNeonatal lupusPositive mothersSecondary preventionSkin rashPrevious pregnancyTreat analysisClinical evidenceRecurrence rateReceptor antagonistOptimal approachDe novo damaging variants associated with congenital heart diseases contribute to the connectome
Ji W, Ferdman D, Copel J, Scheinost D, Shabanova V, Brueckner M, Khokha MK, Ment LR. De novo damaging variants associated with congenital heart diseases contribute to the connectome. Scientific Reports 2020, 10: 7046. PMID: 32341405, PMCID: PMC7184603, DOI: 10.1038/s41598-020-63928-2.Peer-Reviewed Original ResearchMeSH KeywordsConnectomeDNA HelicasesDNA-Binding ProteinsExomeFemaleHeart Defects, CongenitalHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHumansMaleMi-2 Nucleosome Remodeling and Deacetylase ComplexMutationMutation, MissenseMyeloid-Lymphoid Leukemia ProteinNerve Tissue ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Receptor, Notch1ConceptsDe novo variantsNDD genesCardiac patterningDe novo damaging variantsDamaging de novo variantsCHD genesDamaging variantsGenesProtein truncatingGenetic originNovo variantsGene mutationsPatterningRecent studiesDendritic developmentVariantsMutationsNeurogenesisSynaptogenesisBonferroni correction
2019
Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2019, 37: 745-753. PMID: 31121635, DOI: 10.1055/s-0039-1688909.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidBiomarkersChorioamnionitisEchocardiography, DopplerFemaleFetal BloodFetal HeartHumansInfant, NewbornInfant, PrematureInflammationInterleukin-6MaleMass SpectrometryNatriuretic Peptide, BrainPeptide FragmentsPlacentaPregnancyPremature BirthVentricular Function, LeftConceptsIntra-amniotic infection/inflammationBrain natriuretic proteinAmniotic fluidNT-proBNPTei indexNatriuretic proteinVentricular functionFetal exposureCord bloodCord IL-6Intra-amniotic inflammationFetal myocardial functionInfection/inflammationBlood NT-proBNPFetal heart functionNT-proBNP immunoassaysEnzyme-linked immunosorbentGestational agePremature fetusesFetal echocardiogramIL-6Circulatory levelsMyocardial functionHeart functionFetuses
2003
Pulmonary hypoplasia and persistent pulmonary hypertension in the newborn with homozygous α-thalassemia: a case report and review of the literature
Bizzarro M, Copel J, Pearson H, Pober B, Bhandari V. Pulmonary hypoplasia and persistent pulmonary hypertension in the newborn with homozygous α-thalassemia: a case report and review of the literature. The Journal Of Maternal-Fetal & Neonatal Medicine 2003, 14: 411-416. PMID: 15061322, DOI: 10.1080/14767050412331312280.Peer-Reviewed Original Research
2002
Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies
Askanase A, Friedman D, Copel J, Dische M, Dubin A, Starc T, Katholi M, Buyon J. Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies. Lupus 2002, 11: 145-151. PMID: 11999879, DOI: 10.1191/0961203302lu173oa.Peer-Reviewed Original ResearchConceptsSSA/Ro-SSB/La antibodiesThird-degree blockCongenital heart blockLa antibodiesSecond-degree blockConduction abnormalitiesDegree blockNeonatal lupusHeart blockAV blockAtrial rateAV nodeAntibody-mediated inflammationMean atrial rateAdvanced AV blockTime of surgeryFirst-degree blockSpectrum of arrhythmiasNormal sinus rhythmAge 10 yearsIncomplete AV blockCardiac manifestationsNodal involvementSinus bradycardiaSubsequent fibrosis
2000
Color Doppler imaging of placental masses: differential diagnosis and fetal outcome
Prapas N, Liang R, Hunter D, Copel J, Lu L, Pazkash V, Mari G. Color Doppler imaging of placental masses: differential diagnosis and fetal outcome. Ultrasound In Obstetrics And Gynecology 2000, 16: 559-563. PMID: 11169351, DOI: 10.1046/j.1469-0705.2000.00324.x.Peer-Reviewed Original ResearchConceptsCases of chorioangiomaPlacental massPlacental hemorrhagePremature laborDifferential diagnosisRapid tumor growthColor Doppler imagingColor flow mappingPlacental chorioangiomaFetal outcomesPerinatal outcomesNeonatal deathRetrospective studyDoppler examinationBlood flowChorioangiomaColor DopplerDoppler imagingTumor growthHemorrhageHalf year periodFlow mappingOnly caseDiagnosisSuch masses
1998
Autoimmune-Associated Congenital Heart Block: Demographics, Mortality, Morbidity and Recurrence Rates Obtained From a National Neonatal Lupus Registry
Buyon J, Hiebert R, Copel J, Craft J, Friedman D, Katholi M, Lee L, Provost T, Reichlin M, Rider L, Rupel A, Saleeb S, Weston W, Skovron M. Autoimmune-Associated Congenital Heart Block: Demographics, Mortality, Morbidity and Recurrence Rates Obtained From a National Neonatal Lupus Registry. Journal Of The American College Of Cardiology 1998, 31: 1658-1666. PMID: 9626848, DOI: 10.1016/s0735-1097(98)00161-2.Peer-Reviewed Original ResearchConceptsCongenital heart blockNeonatal lupus syndromeSSA/RoWeeks of gestationRecurrence rateLa antibodiesSubsequent pregnancySSA/Ro-SSB/La antibodiesAutoantibody-associated congenital heart blockDevelopment of CHBAnti-SSB/La antibodiesAnti-SSA/RoIsolated congenital heart blockClose echocardiographic monitoringLate second trimesterDays of lifeSSB/LaSufficient medical recordsMajor structural abnormalitiesMaternal autoantibodiesLupus syndromeNeonatal lupusEchocardiographic monitoringLupus RegistryHeart block
1995
Successful in utero therapy of fetal heart block
Copel J, Buyon J, Kleinman C. Successful in utero therapy of fetal heart block. American Journal Of Obstetrics And Gynecology 1995, 173: 1384-1390. PMID: 7503173, DOI: 10.1016/0002-9378(95)90621-5.Peer-Reviewed Original ResearchConceptsComplete heart blockFetal heart blockHeart blockAntibody levelsCongenital complete heart blockHeart block patientsMaternal antibody levelsPositive antibody screenSimilar antibody levelsSecond-degree blockDegree of blockCardiac conduction systemFetal cardiac conduction systemConcurrent myocarditisGlucocorticoid therapyMaternal autoantibodiesBlock patientsMaternal antibodiesAntibody screenUtero therapyCord samplesCardiac contractilityRapid resolutionB antibodiesCardiac conduction
1985
In utero diagnosis and treatment of fetal supraventricular tachycardia.
Kleinman C, Copel J, Weinstein E, Santulli T, Hobbins J. In utero diagnosis and treatment of fetal supraventricular tachycardia. Seminars In Perinatology 1985, 9: 113-29. PMID: 4035386.Peer-Reviewed Original Research