2023
Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally
Bobba P, Weber C, Malhotra A, Bahtiyar M, Copel J, Taylor S, Ment L, Payabvash S. Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally. Scientific Reports 2023, 13: 21514. PMID: 38057452, PMCID: PMC10700578, DOI: 10.1038/s41598-023-48963-z.Peer-Reviewed Original Research
2022
Postpartum cervical length as a predictor of subsequent preterm birth—novel insights on an old enigma
Lauterbach R, Bachar G, Ben-David C, Justman N, Siegler Y, Tzur L, Copel JA, Weiner Z, Beloosesky R, Ginsberg Y. Postpartum cervical length as a predictor of subsequent preterm birth—novel insights on an old enigma. American Journal Of Obstetrics And Gynecology 2022, 228: 461.e1-461.e8. PMID: 36265677, DOI: 10.1016/j.ajog.2022.10.012.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthSubsequent spontaneous preterm birthCervical lengthCervical length measurementPreterm birthPreterm birth groupGestational ageHours postpartumWeeks postpartumTerm groupBirth groupShort cervical lengthSubsequent preterm birthAdverse perinatal outcomesMaternal risk factorsProspective cohort studySingle tertiary centerGroup of patientsPhase 1Perinatal outcomesCohort studyTerm deliveryTertiary centerSubsequent pregnancyPostpartum periodImpact of prenatally diagnosed congenital heart defects on outcomes and management
Wong J, Kohari K, Bahtiyar MO, Copel J. Impact of prenatally diagnosed congenital heart defects on outcomes and management. Journal Of Clinical Ultrasound 2022, 50: 646-654. PMID: 35543387, DOI: 10.1002/jcu.23219.Peer-Reviewed Original ResearchConceptsCongenital heart defectsComplex congenital heart defectEarly fetal echocardiographyImproved survival ratesPrenatal detection rateGood psychosocial supportFetal echocardiogramFetal echocardiographyPatient educationCardiology specialistsHigh riskHeart defectsSurvival rateCongenital heartPsychosocial supportEarly detectionPrenatal identificationPrenatal detectionDelivery planningDetection rateUltrasound technologyImportant contributorEchocardiogramEchocardiographyNeonatesNAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone
Sunderji S, Peyvandi S, Jaeggi E, Szwast A, Ryan G, Tessier F, Siddiqui S, Cuneo B, Sheth S, Treadwell M, Frommelt M, Turan S, Copel J, Emery S, Rand L, Moon-Grady AJ, Network F. NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone. The Journal Of Maternal-Fetal & Neonatal Medicine 2022, 35: 9263-9270. PMID: 35014577, DOI: 10.1080/14767058.2022.2025536.Peer-Reviewed Original ResearchConceptsPositive pregnanciesPrimary outcomePregnancy complicationsPregnancy outcomesPremature deliverySecondary outcomesNorth American Fetal Therapy Network (NAFTNet) centersRo/SSA-positive pregnanciesRetrospective multi-center cohort studyAnti-Ro/SSAMulti-center cohort studyFetal heart blockOverall pregnancy complicationsBetter pregnancy outcomesPoor pregnancy outcomesUse of dexamethasoneTerms of efficacyHigh rateFetal dyadsMaternal comorbiditiesAntibody positivityExpectant managementMaternal diseaseNeonatal morbidityPreterm delivery
2020
Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation
Friedman DM, Kim M, Costedoat-Chalumeau N, Clancy R, Copel J, Phoon CK, Cuneo B, Cohen R, Masson M, Wainwright BJ, Zahr N, Saxena A, Izmirly P, Buyon JP. Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation. Circulation Arrhythmia And Electrophysiology 2020, 13: e008686. PMID: 32907357, PMCID: PMC7668319, DOI: 10.1161/circep.120.008686.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsCardiotoxicityDrug Administration ScheduleDrug MonitoringElectrocardiographyFemaleFetal BloodFetal HeartGestational AgeHeart BlockHeart RateHumansHydroxychloroquineInfantInfant, NewbornMalePredictive Value of TestsPregnancyRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsBlood levelsSSA/Ro antibodiesHistorical healthy controlsHydroxychloroquine blood levelsCord blood levelsCongenital heart blockSystemic lupus erythematosusTrimester of pregnancyEfficacy of hydroxychloroquineCoronavirus disease-19Electrocardiographic QT intervalCOVID-19 studiesPostnatal ECGRo antibodiesIndividual pregnanciesLupus erythematosusQTc prolongationAntiviral therapyHeart blockClinical efficacyRheumatic conditionsDrug exposureMaternal useCord bloodDisease-19Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers
Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA, Phoon CKL, Cuneo BF, Cohen RE, Robins K, Masson M, Wainwright BJ, Zahr N, Saxena A, Buyon JP. Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers. Journal Of The American College Of Cardiology 2020, 76: 292-302. PMID: 32674792, PMCID: PMC7394202, DOI: 10.1016/j.jacc.2020.05.045.Peer-Reviewed Original ResearchConceptsCongenital heart blockPrimary outcomeSecondary outcomesEndocardial fibroelastosisHeart blockRecurrence of CHBSSA/Ro-positive mothersAnti-SSA/RoMacrophage Toll-like receptorToll-like receptor antagonistsCutaneous neonatal lupusRo-positive mothersGestational weeks 10Toll-like receptorsFetal cardiac diseaseNeonatal lupusPositive mothersSecondary preventionSkin rashPrevious pregnancyTreat analysisClinical evidenceRecurrence rateReceptor antagonistOptimal approach
2019
Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2019, 37: 745-753. PMID: 31121635, DOI: 10.1055/s-0039-1688909.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidBiomarkersChorioamnionitisEchocardiography, DopplerFemaleFetal BloodFetal HeartHumansInfant, NewbornInfant, PrematureInflammationInterleukin-6MaleMass SpectrometryNatriuretic Peptide, BrainPeptide FragmentsPlacentaPregnancyPremature BirthVentricular Function, LeftConceptsIntra-amniotic infection/inflammationBrain natriuretic proteinAmniotic fluidNT-proBNPTei indexNatriuretic proteinVentricular functionFetal exposureCord bloodCord IL-6Intra-amniotic inflammationFetal myocardial functionInfection/inflammationBlood NT-proBNPFetal heart functionNT-proBNP immunoassaysEnzyme-linked immunosorbentGestational agePremature fetusesFetal echocardiogramIL-6Circulatory levelsMyocardial functionHeart functionFetuses
2012
Evaluating the cost‐effectiveness of prenatal surgery for myelomeningocele: a decision analysis
Werner E, Han C, Burd I, Lipkind H, Copel J, Bahtiyar M, Thung S. Evaluating the cost‐effectiveness of prenatal surgery for myelomeningocele: a decision analysis. Ultrasound In Obstetrics And Gynecology 2012, 40: 158-164. PMID: 22511529, DOI: 10.1002/uog.11176.Peer-Reviewed Original ResearchConceptsPrenatal myelomeningocele repairQuality-adjusted life yearsMyelomeningocele repairPostnatal repairMyelomeningocele patientsPrenatal surgeryAdditional casesLong-term medical careFuture pregnancy complicationsIncremental cost-effectiveness ratioPostnatal myelomeningocele repairCost-effectiveness ratioDecision analysis modelingUterine ruptureNeurologic deficitsPregnancy complicationsSingleton gestationsSurgery resultsLife yearsMedical carePatientsCost-effective strategyNormal karyotypeNeonatesSurgery
2008
Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimester
2003
Delivery at 34 weeks is more costly than at 35 weeks in pregnancies with premature rupture of membranes
Magriples U, Crichton R, Ehrenkranz R, Copel J. Delivery at 34 weeks is more costly than at 35 weeks in pregnancies with premature rupture of membranes. The Journal Of Maternal-Fetal & Neonatal Medicine 2003, 14: 22-25. PMID: 14563087, DOI: 10.1080/jmf.14.1.22.25.Peer-Reviewed Original ResearchConceptsPremature ruptureIntensive care unit stayPreterm premature ruptureMother-infant pairsUnit stayMaternal demographicsNeonatal morbidityPreterm PROMSingleton gestationsNeonatal interventionsNeonatal lengthRetrospective studyProspective dataRelative riskDelay of deliveryWeeksDirect costsSignificant differencesPatientsSignificant increaseStayInfantsDeliveryCost of deliveryRupturePulmonary hypoplasia and persistent pulmonary hypertension in the newborn with homozygous α-thalassemia: a case report and review of the literature
Bizzarro M, Copel J, Pearson H, Pober B, Bhandari V. Pulmonary hypoplasia and persistent pulmonary hypertension in the newborn with homozygous α-thalassemia: a case report and review of the literature. The Journal Of Maternal-Fetal & Neonatal Medicine 2003, 14: 411-416. PMID: 15061322, DOI: 10.1080/14767050412331312280.Peer-Reviewed Original Research
2002
Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies
Askanase A, Friedman D, Copel J, Dische M, Dubin A, Starc T, Katholi M, Buyon J. Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies. Lupus 2002, 11: 145-151. PMID: 11999879, DOI: 10.1191/0961203302lu173oa.Peer-Reviewed Original ResearchConceptsSSA/Ro-SSB/La antibodiesThird-degree blockCongenital heart blockLa antibodiesSecond-degree blockConduction abnormalitiesDegree blockNeonatal lupusHeart blockAV blockAtrial rateAV nodeAntibody-mediated inflammationMean atrial rateAdvanced AV blockTime of surgeryFirst-degree blockSpectrum of arrhythmiasNormal sinus rhythmAge 10 yearsIncomplete AV blockCardiac manifestationsNodal involvementSinus bradycardiaSubsequent fibrosis
2001
Anti‐Ro/SSA antibodies and congenital heart block: Necessary but not sufficient
Buyon J, Kim M, Copel J, Friedman D. Anti‐Ro/SSA antibodies and congenital heart block: Necessary but not sufficient. Arthritis & Rheumatism 2001, 44: 1723-1727. PMID: 11508420, DOI: 10.1002/1529-0131(200108)44:8<1723::aid-art305>3.0.co;2-0.Peer-Reviewed Original ResearchIsolated major congenital heart disease
Allan L, Benacerraf B, Copel J, Carvalho J, Chaoui R, Eik-Nes S, Tegnander E, Gembruch U, Huhta J, Pilu G, Wladimiroff J, Yagel S. Isolated major congenital heart disease. Ultrasound In Obstetrics And Gynecology 2001, 17: 370-379. PMID: 11380959, DOI: 10.1046/j.1469-0705.2001.00439.x.Peer-Reviewed Original ResearchPrenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient
Verheijen P, Lisowski L, Stoutenbeek P, Hitchcock J, Brenner J, Copel J, Kleinman C, Meijboom E, Bennink G. Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient. Journal Of Thoracic And Cardiovascular Surgery 2001, 121: 798-803. PMID: 11279423, DOI: 10.1067/mtc.2001.112825.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseHeart diseaseLower base excessHeart obstructionMetabolic acidosisBase excessDuctus-dependent congenital heart diseasePrenatal diagnosisPostnatal diagnosisImproved long-term outcomesGroup of patientsArterial blood gasesLong-term outcomesCause of deathHigher lactate levelsDays of lifePrevention of acidosisSignificant differencesBiventricular repairPreoperative conditionCerebral damageRetrospective studySurgical outcomesPreoperative acidosisBlood gases
2000
The clinical significance of the irregular fetal heart rhythm
Copel J, Liang R, Demasio K, Ozeren S, Kleinman C. The clinical significance of the irregular fetal heart rhythm. American Journal Of Obstetrics And Gynecology 2000, 182: 813-819. PMID: 10764457, DOI: 10.1016/s0002-9378(00)70330-9.Peer-Reviewed Original ResearchConceptsFetal heart rhythmSignificant arrhythmiasHeart rhythmFetal echocardiographyStructural heart diseaseRoutine prenatal careRetrospective reviewFetal echocardiogramPrenatal careHeart diseaseFetal arrhythmiasClinical significanceClinical practiceArrhythmiasAppropriate managementFetusesIrregular rhythmNormal rhythmDifferent fetusesEchocardiographyRhythmImportant proportionLittle informationEchocardiogramNeonatesNoninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization
Mari G, Deter R, Carpenter R, Rahman F, Zimmerman R, Moise K, Dorman K, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel J, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell S. Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization. New England Journal Of Medicine 2000, 342: 9-14. PMID: 10620643, DOI: 10.1056/nejm200001063420102.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityBlood Group IncompatibilityCordocentesisErythroblastosis, FetalErythrocytesFemaleFetal BloodGestational AgeHemoglobinsHumansInfant, NewbornIsoantibodiesMiddle Cerebral ArteryPregnancyPregnancy Complications, HematologicProspective StudiesReference ValuesRh IsoimmunizationROC CurveSensitivity and SpecificityUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMaternal red cell alloimmunizationRed cell alloimmunizationMiddle cerebral arterySystolic blood flowCerebral arteryBlood flowSevere anemiaFetal anemiaDoppler ultrasonographyNormal fetusesHemoglobin concentrationFetal middle cerebral arteryPeak velocityFetal hemoglobin concentrationAbsence of hydropsPeak systolic velocityGestational ageModerate anemiaSystolic velocityHemoglobin valuesMild anemiaInvasive techniquesAlloimmunizationAnemiaArtery
1999
Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: Retrospective review of the research registry for neonatal lupus
Saleeb S, Copel J, Friedman D, Buyon J. Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: Retrospective review of the research registry for neonatal lupus. Arthritis & Rheumatism 1999, 42: 2335-2345. PMID: 10555029, DOI: 10.1002/1529-0131(199911)42:11<2335::aid-anr12>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsCongenital heart blockSecond-degree blockThird-degree blockGroup B fetusesGroup BGroup AHeart blockAge 4 yearsNeonatal lupusPericardial effusionPleural effusionResearch RegistryFluorinated steroidsAutoantibody-associated congenital heart blockAnti-SSB/La antibodiesAnti-SSA/RoFluorinated glucocorticoidsNatural historyInitial echocardiographic evaluationDuration of pregnancyIntrauterine growth restrictionFirst-degree blockNumber of deathsComparison of treatmentsSteroid therapySelective Screening for Gestational Diabetes Mellitus in Adolescent Pregnancies
KHINE M, WINKLESTEIN A, COPEL J. Selective Screening for Gestational Diabetes Mellitus in Adolescent Pregnancies. Obstetrics And Gynecology 1999, 93: 738-742. DOI: 10.1097/00006250-199905000-00020.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusBody mass indexAdolescent gravidasRisk factorsGestational diabetesRace/ethnicityDiabetes mellitusMass indexHigh prevalenceFamily historyMedical disordersBasis of BMIPrevalence of GDMAdolescent pregnancySelective screeningConclusion Body mass indexGDM risk factorsPrevious obstetric historyImportant risk factorStudent's t-testObstetric historyAdolescent patientsDiseases codesAnomalous fetusesInternational ClassificationThe Doppler cerebroplacental ratio and perinatal outcome in intrauterine growth restriction
Bahado-Singh R, Kovanci E, Jeffres A, Oz U, Deren O, Copel J, Mari G. The Doppler cerebroplacental ratio and perinatal outcome in intrauterine growth restriction. American Journal Of Obstetrics And Gynecology 1999, 180: 750-756. PMID: 10076158, DOI: 10.1016/s0002-9378(99)70283-8.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionDoppler cerebroplacental ratioPerinatal outcomesCerebroplacental ratioBirth weightGrowth restrictionDoppler examinationUmbilical artery pulsatility index valuesStepwise logistic regression analysisAbnormal cerebroplacental ratioBrain-sparing effectLast Doppler examinationUmbilical artery DopplerUmbilical artery velocimetryPulsatility index valuesReceiver operator curve characteristicsReceiver operator characteristic curveLogistic regression analysisRegression analysisArtery DopplerPerinatal morbidityPerinatal complicationsWeeks' gestationNormal medianPerinatal problems