2019
Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2019, 37: 745-753. PMID: 31121635, DOI: 10.1055/s-0039-1688909.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidBiomarkersChorioamnionitisEchocardiography, DopplerFemaleFetal BloodFetal HeartHumansInfant, NewbornInfant, PrematureInflammationInterleukin-6MaleMass SpectrometryNatriuretic Peptide, BrainPeptide FragmentsPlacentaPregnancyPremature BirthVentricular Function, LeftConceptsIntra-amniotic infection/inflammationBrain natriuretic proteinAmniotic fluidNT-proBNPTei indexNatriuretic proteinVentricular functionFetal exposureCord bloodCord IL-6Intra-amniotic inflammationFetal myocardial functionInfection/inflammationBlood NT-proBNPFetal heart functionNT-proBNP immunoassaysEnzyme-linked immunosorbentGestational agePremature fetusesFetal echocardiogramIL-6Circulatory levelsMyocardial functionHeart functionFetuses
1999
Gestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk
Bahado‐Singh R, Oz U, Kovanci E, Deren O, Feather M, Hsu C, Copel J, Mahoney M. Gestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk. The Journal Of Maternal-Fetal Medicine 1999, 8: 37-43. PMID: 10090488, DOI: 10.1002/(sici)1520-6661(199903/04)8:2<37::aid-mfm1>3.0.co;2-p.Peer-Reviewed Original ResearchA high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome riskNitric Oxide: A Clinically Important Amniotic Fluid Markerto Distinguish Between Intra-Amniotic Mycoplasma and Non-Mycoplasma Infections
Hsu C, Aversa K, Lu L, Meaddough E, Jones D, Bahado-Singh R, Copel J, Lee I. Nitric Oxide: A Clinically Important Amniotic Fluid Markerto Distinguish Between Intra-Amniotic Mycoplasma and Non-Mycoplasma Infections. American Journal Of Perinatology 1999, 16: 161-166. PMID: 10458527, DOI: 10.1055/s-2007-993851.Peer-Reviewed Original ResearchConceptsAmniotic fluid testsIntra-amniotic infectionInterleukin-6Mycoplasma infectionLeukocyte countFluid testsAmniotic fluid creatinine levelsAmniotic fluid glucose levelNitric oxide metabolite concentrationsPositive amniotic fluid cultureInterleukin-6 concentrationsManagement of patientsAmniotic fluid concentrationsAmniotic fluid leukocyte countsAmniotic fluid cultureClinical characteristicsCreatinine levelsPregnant womenClinical managementFluid cultureGlucose levelsClinical importanceUseful markerGriess reagentInfection
1998
New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age
Bahado-Singh R, Oz A, Kovanci E, Deren O, Copel J, Baumgarten A, Mahoney J. New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age. American Journal Of Obstetrics And Gynecology 1998, 179: 1627-1631. PMID: 9855608, DOI: 10.1016/s0002-9378(98)70036-5.Peer-Reviewed Original ResearchConceptsHumerus length measurementsSerum markersDown syndromeMaternal ageTriple screenHumerus lengthMultiple stepwise logistic regression analysisTriple-marker serum screeningSerum analytesStepwise logistic regression analysisScreening algorithmHigh-risk populationFetal Down syndromeMultiple serum markersDown syndrome screeningHuman chorionic gonadotropinLogistic regression analysisNew screening algorithmDown's syndrome screening efficiencyPrenatal Down syndrome screeningDown syndrome detectionFalse positive rateSerum screenSingleton fetusesUnconjugated estriolAn alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers
Bahado-Singh R, Deren O, Oz U, Tan A, Hunter D, Copel J, Mahoney M. An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers. American Journal Of Obstetrics And Gynecology 1998, 179: 514-519. PMID: 9731862, DOI: 10.1016/s0002-9378(98)70388-6.Peer-Reviewed Original ResearchConceptsHyperechoic fetal bowelMaternal ageDown syndromeFetal bowelUltrasonographic parametersScreen-positive rateSignificant independent predictorsAge-related riskDown syndrome riskIndividual oddsLikelihood ratioPositive predictive valueHypoplastic fifth digitDigit hypoplasiaWeeks' gestationIndependent predictorsNormal medianIndividual Down syndrome oddsSingleton fetusesSyndrome riskUltrasonographic markersSerum screeningGenetic amniocentesisHigh riskNuchal thickeningThe role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection
Hsu C, Meaddough E, Aversa K, Copel J. The role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection. American Journal Of Obstetrics And Gynecology 1998, 178: 428-432. PMID: 9539502, DOI: 10.1016/s0002-9378(98)70414-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCarboxylic Ester HydrolasesChemokine CXCL1ChemokinesChemokines, CXCChemotactic FactorsCreatinineFemaleGlucoseGrowth SubstancesHumansInfectionsIntercellular Signaling Peptides and ProteinsInterleukin-8Leukocyte CountL-SelectinPregnancyStatistics, NonparametricConceptsSoluble L-selectinIntraamniotic infectionAmniotic fluid levelsInterleukin-8L-selectinPregnant womenRank correlation testFluid levelsAmniotic fluid creatinine levelsPositive amniotic fluid cultureAmniotic fluid glucose concentrationAmniotic fluid leukocytesRupture of membranesAmniotic fluid leukocyte countsMann-Whitney UtestAmniotic fluid testsPotent leukocyte chemoattractantLeukocyte esterase activityAmniotic fluid cultureEnzyme-linked immunoassayPreterm contractionsCreatinine levelsSpearman rank correlation testLeukocyte countFluid cultureDual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection
Hsu C, Meaddough E, Aversa K, Hong S, Lee I, Bahodo-Singh R, Lu L, Copel J. Dual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection. American Journal Of Perinatology 1998, 15: 683-687. PMID: 10333395, DOI: 10.1055/s-2007-999302.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionNitric oxide metabolitesPreterm labor patientsAmniotic fluid nitric oxide metabolitesProstaglandin E2Preterm laborLabor patientsNitric oxideIntraamniotic infectionAmniotic fluidAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid creatinineProinflammatory nitric oxidePro-inflammatory nitric oxideAmniotic fluid concentrationsAmniotic fluid levelsNitric oxide synthaseCyclo-oxygenase-2Amniotic fluid cultureEnzyme-linked immunoassayOxide metabolitesLeukocyte countFluid cultureOxide synthase
1995
Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results
Bahado-Singh R, Goldstein I, Uerpairojkit B, Copel J, Mahoney M, Baumgarten A. Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results. American Journal Of Obstetrics And Gynecology 1995, 173: 1106-1110. PMID: 7485301, DOI: 10.1016/0002-9378(95)91334-3.Peer-Reviewed Original ResearchConceptsAbnormal triple-screen resultsTriple-screen resultsNuchal thicknessDown syndromeHuman chorionic gonadotropin levelsNuchal thickness measurementChorionic gonadotropin levelsReceiver operator characteristic curveNumber of amniocentesesReceiver operator characteristic plotsRisk thresholdMidtrimester pregnancyGonadotropin levelsWeeks' gestationMaternal ageConsecutive fetusesUnconjugated estriolSerum screeningEuploid fetusesAlpha-fetoproteinSyndromeTrisomy 21Screen resultsRisk estimatesFetusesInvasive techniques for prenatal diagnosis: current concepts.
Bahado-Singh R, Morotti R, Pirhonen J, Copel J, Mahoney M. Invasive techniques for prenatal diagnosis: current concepts. Journal Of The Association For Academic Minority Physicians 1995, 6: 28-33. PMID: 7858373.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1993
Ultrasound screening for fetal structural anomalies
Gomez K, Copel J. Ultrasound screening for fetal structural anomalies. Current Opinion In Obstetrics & Gynecology 1993, 5: 204-210. PMID: 8490090, DOI: 10.1097/00001703-199304000-00006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFetal structural anomaliesStructural anomaliesRoutine ultrasound screeningFour-chamber viewNeural tube defectsRoutine ultrasoundUltrasound screeningHigh riskUltrasound prenatal diagnosisTube defectsUltrasoundPregnancyPrenatal diagnosisDiagnostic ultrasoundControversial topicPatientsObstetricsFetusesAmniocentesisDiagnosis