2022
Impact of prenatally diagnosed congenital heart defects on outcomes and management
Wong J, Kohari K, Bahtiyar MO, Copel J. Impact of prenatally diagnosed congenital heart defects on outcomes and management. Journal Of Clinical Ultrasound 2022, 50: 646-654. PMID: 35543387, DOI: 10.1002/jcu.23219.Peer-Reviewed Original ResearchConceptsCongenital heart defectsComplex congenital heart defectEarly fetal echocardiographyImproved survival ratesPrenatal detection rateGood psychosocial supportFetal echocardiogramFetal echocardiographyPatient educationCardiology specialistsHigh riskHeart defectsSurvival rateCongenital heartPsychosocial supportEarly detectionPrenatal identificationPrenatal detectionDelivery planningDetection rateUltrasound technologyImportant contributorEchocardiogramEchocardiographyNeonatesNAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone
Sunderji S, Peyvandi S, Jaeggi E, Szwast A, Ryan G, Tessier F, Siddiqui S, Cuneo B, Sheth S, Treadwell M, Frommelt M, Turan S, Copel J, Emery S, Rand L, Moon-Grady AJ, Network F. NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone. The Journal Of Maternal-Fetal & Neonatal Medicine 2022, 35: 9263-9270. PMID: 35014577, DOI: 10.1080/14767058.2022.2025536.Peer-Reviewed Original ResearchConceptsPositive pregnanciesPrimary outcomePregnancy complicationsPregnancy outcomesPremature deliverySecondary outcomesNorth American Fetal Therapy Network (NAFTNet) centersRo/SSA-positive pregnanciesRetrospective multi-center cohort studyAnti-Ro/SSAMulti-center cohort studyFetal heart blockOverall pregnancy complicationsBetter pregnancy outcomesPoor pregnancy outcomesUse of dexamethasoneTerms of efficacyHigh rateFetal dyadsMaternal comorbiditiesAntibody positivityExpectant managementMaternal diseaseNeonatal morbidityPreterm delivery
2021
Utility of routine screening fetal echocardiogram in pregnancies conceived by in vitro fertilization
Bjorkman KR, Bjorkman SH, Ferdman DJ, Sfakianaki AK, Copel JA, Bahtiyar MO. Utility of routine screening fetal echocardiogram in pregnancies conceived by in vitro fertilization. Fertility And Sterility 2021, 116: 801-808. PMID: 34210397, DOI: 10.1016/j.fertnstert.2021.04.035.Peer-Reviewed Original ResearchConceptsFetal echocardiogramIncidence of CHDFetal echocardiographyIVF pregnanciesRisk factorsIVF groupInsignificant ventricular septal defectsLarge tertiary care centerStatewide hospital discharge dataMean gestational ageTertiary care centerCases of CHDHospital discharge dataRoutine prenatal careVentricular septal defectConfidence intervalsPopulation ratesBirth Defects RegistrySignificant CHDMedication exposureCohort studyPulmonary stenosisPrevious pregnancyGestational ageInfant outcomes
2020
Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation
Friedman DM, Kim M, Costedoat-Chalumeau N, Clancy R, Copel J, Phoon CK, Cuneo B, Cohen R, Masson M, Wainwright BJ, Zahr N, Saxena A, Izmirly P, Buyon JP. Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation. Circulation Arrhythmia And Electrophysiology 2020, 13: e008686. PMID: 32907357, PMCID: PMC7668319, DOI: 10.1161/circep.120.008686.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsCardiotoxicityDrug Administration ScheduleDrug MonitoringElectrocardiographyFemaleFetal BloodFetal HeartGestational AgeHeart BlockHeart RateHumansHydroxychloroquineInfantInfant, NewbornMalePredictive Value of TestsPregnancyRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsBlood levelsSSA/Ro antibodiesHistorical healthy controlsHydroxychloroquine blood levelsCord blood levelsCongenital heart blockSystemic lupus erythematosusTrimester of pregnancyEfficacy of hydroxychloroquineCoronavirus disease-19Electrocardiographic QT intervalCOVID-19 studiesPostnatal ECGRo antibodiesIndividual pregnanciesLupus erythematosusQTc prolongationAntiviral therapyHeart blockClinical efficacyRheumatic conditionsDrug exposureMaternal useCord bloodDisease-19
2019
Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2019, 37: 745-753. PMID: 31121635, DOI: 10.1055/s-0039-1688909.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidBiomarkersChorioamnionitisEchocardiography, DopplerFemaleFetal BloodFetal HeartHumansInfant, NewbornInfant, PrematureInflammationInterleukin-6MaleMass SpectrometryNatriuretic Peptide, BrainPeptide FragmentsPlacentaPregnancyPremature BirthVentricular Function, LeftConceptsIntra-amniotic infection/inflammationBrain natriuretic proteinAmniotic fluidNT-proBNPTei indexNatriuretic proteinVentricular functionFetal exposureCord bloodCord IL-6Intra-amniotic inflammationFetal myocardial functionInfection/inflammationBlood NT-proBNPFetal heart functionNT-proBNP immunoassaysEnzyme-linked immunosorbentGestational agePremature fetusesFetal echocardiogramIL-6Circulatory levelsMyocardial functionHeart functionFetusesUtility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine 2019, 38: 2361-2372. PMID: 30653685, DOI: 10.1002/jum.14931.Peer-Reviewed Original ResearchConceptsAbnormal cardiac axisNegative predictive valueFetal cardiac axisNeonatal respiratory morbidityRespiratory morbidityCongenital lung lesionsCardiac positionPositive predictive valuePredictive valueCardiac axisLung lesionsHigh negative predictive valueSevere respiratory morbidityRetrospective cohort studyRight-sided lesionsNormal cardiac axisCohort studyWeeks' gestationMorbidityCP assessmentWeeksDiagnostic performanceLesionsPatientsGestation
2013
ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart
International Society of Ultrasound in Obstetrics and Gynecology, Carvalho J, Allan L, Chaoui R, Copel J, DeVore G, Hecher K, Lee W, Munoz H, Paladini D, Tutschek B, Yagel S. ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart. Ultrasound In Obstetrics And Gynecology 2013, 41: 348-359. PMID: 23460196, DOI: 10.1002/uog.12403.Commentaries, Editorials and Letters
2011
Assessment of the fetal thymus by two‐ and three‐dimensional ultrasound during normal human gestation and in fetuses with congenital heart defects
Li L, Bahtiyar M, Buhimschi C, Zou L, Zhou Q, Copel J. Assessment of the fetal thymus by two‐ and three‐dimensional ultrasound during normal human gestation and in fetuses with congenital heart defects. Ultrasound In Obstetrics And Gynecology 2011, 37: 404-409. PMID: 20886509, DOI: 10.1002/uog.8853.Peer-Reviewed Original Research
2008
Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimester
2004
Indications for Fetal Echocardiography
Small M, Copel J. Indications for Fetal Echocardiography. Pediatric Cardiology 2004, 25: 210-222. PMID: 15360114, DOI: 10.1007/s00246-003-0587-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2001
Isolated major congenital heart disease
Allan L, Benacerraf B, Copel J, Carvalho J, Chaoui R, Eik-Nes S, Tegnander E, Gembruch U, Huhta J, Pilu G, Wladimiroff J, Yagel S. Isolated major congenital heart disease. Ultrasound In Obstetrics And Gynecology 2001, 17: 370-379. PMID: 11380959, DOI: 10.1046/j.1469-0705.2001.00439.x.Peer-Reviewed Original Research
1997
Does a prenatal diagnosis of congenital heart disease alter short‐term outcome?
Copel J, Tan A, Kleinman C. Does a prenatal diagnosis of congenital heart disease alter short‐term outcome? Ultrasound In Obstetrics And Gynecology 1997, 10: 237-241. PMID: 9383873, DOI: 10.1046/j.1469-0705.1997.10040237.x.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseLength of hospitalizationPrenatal diagnosis groupInitial hospitalizationDiagnosis groupsGroup IBiventricular repairHeart diseaseOutcome measuresGroup IIPrenatal diagnosisLong-term mortality riskYale-New Haven HospitalDuctal-dependent lesionsFatal congenital anomalyStudy entry criteriaSingle ventricle physiologyPrimary outcome measureShort-term outcomesCost of hospitalizationLife-threatening conditionHospital dischargePrimary admissionVentricle physiologyAntenatal cases
1994
Management outcome and follow-up of fetal tachycardia
van Engelen A, Weijtens O, Brenner J, Kleinman C, Copel J, Stoutenbeek P, Meijboom E. Management outcome and follow-up of fetal tachycardia. Journal Of The American College Of Cardiology 1994, 24: 1371-1375. PMID: 7930263, DOI: 10.1016/0735-1097(94)90122-8.Peer-Reviewed Original ResearchConceptsFetal tachycardiaMajority of patientsPharmacologic therapyFetal hydropsAtrial flutterSupraventricular tachycardiaVentricular tachycardiaPresence of hydropsSeries of patientsLife-threatening conditionSerious adverse effectsMonths of ageMaternal therapyProlonged therapyPostpartum managementRhythm controlAntiarrhythmic agentsMedian numberDrug treatmentTachycardiaM-modePatientsOptimal managementTherapyEmergency deliveryAntenatal diagnosis of coarctation of the aorta: A multicenter experience
Hornberger L, Sahn D, Kleinman C, Copel J, Silverman N. Antenatal diagnosis of coarctation of the aorta: A multicenter experience. Journal Of The American College Of Cardiology 1994, 23: 417-423. PMID: 8294696, DOI: 10.1016/0735-1097(94)90429-4.Peer-Reviewed Original ResearchConceptsTransverse archGestational ageSerial studiesDistal archAortic archDouble outlet right ventricleMembranous ventricular septal defectPrenatal studiesAssociated cardiac lesionsDiagnosis of coarctationDistal arch hypoplasiaDistal aortic archVentricular septal defectUnbalanced atrioventricular canalAbnormal aortic valvePresence of coarctationIsthmus hypoplasiaNoncardiac lesionsPrenatal echocardiogramEchocardiographic findingsArch hypoplasiaMulticenter experienceReversal of flowCardiac lesionsVentricle anatomy
1991
Doppler Echocardiography and Color Flow Mapping
Copel J, Hobbins J, Kleinman C. Doppler Echocardiography and Color Flow Mapping. Obstetrics And Gynecology Clinics Of North America 1991, 18: 845-851. PMID: 1803305, DOI: 10.1016/s0889-8545(21)00255-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsEchocardiography, DopplerFemaleFetal HeartHumansPregnancyPregnancy ComplicationsUltrasonography, PrenatalCongenital Heart Disease and Fetal Thoracoabdominal Anomalies: Associations in Utero and the Importance of Cytogenetic Analysis
Fogel M, Copel J, Cullen M, Hobbins J, Kleinman C. Congenital Heart Disease and Fetal Thoracoabdominal Anomalies: Associations in Utero and the Importance of Cytogenetic Analysis. American Journal Of Perinatology 1991, 8: 411-416. PMID: 1839950, DOI: 10.1055/s-2007-999427.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePosterior diaphragmatic herniaDuodenal atresiaHeart diseaseExtracardiac malformationsDiaphragmatic herniaFetal echocardiographyNormal cardiac structureFetal echocardiogramMost fetusesPrenatal evaluationAbnormal karyotypeCardiac structureCytogenetic abnormalitiesFetusesAtresiaOmphaloceleNormal karyotypeAbnormalitiesDiseaseEchocardiographyGastroschisisHerniaPrenatal diagnosisMalformationsTricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome
Hornberger L, Sahn D, Kleinman C, Copel J, Reed K. Tricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome. Journal Of The American College Of Cardiology 1991, 17: 167-173. PMID: 1987222, DOI: 10.1016/0735-1097(91)90722-l.Peer-Reviewed Original ResearchConceptsTricuspid valve diseasePulmonary atresiaPulmonary stenosisEbstein's anomalyClinical courseValve diseaseUnguarded tricuspid valve orificeSevere congestive heart failureAssociated cardiac lesionsBenign neonatal courseComplex heart lesionsPulmonary outflow obstructionRight atrial dilationRight-sided cardiomegalySignificant tricuspid insufficiencySignificant tricuspid regurgitationCongestive heart failurePulmonary artery flowTricuspid valve dysplasiaTricuspid valve orificeTricuspid tissueNeonatal courseOutflow obstructionTricuspid insufficiencyTricuspid regurgitation
1989
Fetal cardiac output in the isoimmunized pregnancy: A pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion
Copel J, Grannum P, Green J, Belanger K, Hanna N, Jaffe C, Hobbins J, Kleinman C. Fetal cardiac output in the isoimmunized pregnancy: A pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion. American Journal Of Obstetrics And Gynecology 1989, 161: 361-365. PMID: 2504042, DOI: 10.1016/0002-9378(89)90520-6.Peer-Reviewed Original ResearchConceptsCardiac outputAnemic fetusesIsoimmunized pregnanciesCombined ventricular outputDoppler echocardiographic studyFetal cardiac outputHigh output stateHigh cardiac outputIntravascular intrauterine transfusionSevere isoimmunizationCardiac indexIntrauterine transfusionIntravascular transfusionWeeks' gestationVentricular outputDoppler assessmentAge-specific normsControl fetusesHydrops fetalisControl groupMechanisms of developmentFetusesUnaffected fetusesTransfusionPregnancy
1988
Development of a benign intrapericardial tumor between 20 and 40 weeks of gestation
Weber H, Kleinman C, Hellenbrand W, Kopf G, Copel J. Development of a benign intrapericardial tumor between 20 and 40 weeks of gestation. Pediatric Cardiology 1988, 9: 153-156. PMID: 3186538, DOI: 10.1007/bf02080556.Peer-Reviewed Case Reports and Technical Notes
1987
Fetal echocardiographic screening for congenital heart disease: The importance of the four-chamber view
Copel J, Pilu G, Green J, Hobbins J, Kleinman C. Fetal echocardiographic screening for congenital heart disease: The importance of the four-chamber view. American Journal Of Obstetrics And Gynecology 1987, 157: 648-655. PMID: 3631166, DOI: 10.1016/s0002-9378(87)80022-4.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseFour-chamber viewHeart diseasePredictive valueRoutine obstetric ultrasound examinationFetal echocardiographic screeningObstetric ultrasound examinationNegative predictive valuePositive predictive valueObstetrical sonographersEchocardiographic screeningUltrasound examinationDiseaseUseful screenAbnormal heartFetusesHeartScreening methodPregnancyAbnormalities