2021
Utility of routine screening fetal echocardiogram in pregnancies conceived by in vitro fertilization
Bjorkman KR, Bjorkman SH, Ferdman DJ, Sfakianaki AK, Copel JA, Bahtiyar MO. Utility of routine screening fetal echocardiogram in pregnancies conceived by in vitro fertilization. Fertility And Sterility 2021, 116: 801-808. PMID: 34210397, DOI: 10.1016/j.fertnstert.2021.04.035.Peer-Reviewed Original ResearchConceptsFetal echocardiogramIncidence of CHDFetal echocardiographyIVF pregnanciesRisk factorsIVF groupInsignificant ventricular septal defectsLarge tertiary care centerStatewide hospital discharge dataMean gestational ageTertiary care centerCases of CHDHospital discharge dataRoutine prenatal careVentricular septal defectConfidence intervalsPopulation ratesBirth Defects RegistrySignificant CHDMedication exposureCohort studyPulmonary stenosisPrevious pregnancyGestational ageInfant outcomes
2020
Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation
Friedman DM, Kim M, Costedoat-Chalumeau N, Clancy R, Copel J, Phoon CK, Cuneo B, Cohen R, Masson M, Wainwright BJ, Zahr N, Saxena A, Izmirly P, Buyon JP. Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation. Circulation Arrhythmia And Electrophysiology 2020, 13: e008686. PMID: 32907357, PMCID: PMC7668319, DOI: 10.1161/circep.120.008686.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsCardiotoxicityDrug Administration ScheduleDrug MonitoringElectrocardiographyFemaleFetal BloodFetal HeartGestational AgeHeart BlockHeart RateHumansHydroxychloroquineInfantInfant, NewbornMalePredictive Value of TestsPregnancyRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsBlood levelsSSA/Ro antibodiesHistorical healthy controlsHydroxychloroquine blood levelsCord blood levelsCongenital heart blockSystemic lupus erythematosusTrimester of pregnancyEfficacy of hydroxychloroquineCoronavirus disease-19Electrocardiographic QT intervalCOVID-19 studiesPostnatal ECGRo antibodiesIndividual pregnanciesLupus erythematosusQTc prolongationAntiviral therapyHeart blockClinical efficacyRheumatic conditionsDrug exposureMaternal useCord bloodDisease-19
2019
Gottesfeld-Hohler Memorial Foundation Risk Assessment for Early-Onset Preeclampsia in the United States: Think Tank Summary.
Copel JA, Platt LD, Hobbins JC, Afshar Y, Grechukhina O, Mallampati D, Bromley B, Caughey AB, Grobman W, Han CS, Nicolaides K, Pettker C, Saade G, Sibai B, Simhan H, Sonek J, Werner E, Chescheir N. Gottesfeld-Hohler Memorial Foundation Risk Assessment for Early-Onset Preeclampsia in the United States: Think Tank Summary. Obstetrics And Gynecology 2019, 135: 36-45. PMID: 31809427, DOI: 10.1097/aog.0000000000003582.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEarly-onset preeclampsiaSubstantial economic burdenCost-effectiveness dataAspirin prophylaxisNeonatal morbidityPreterm preeclampsiaProphylactic usePreventive strategiesEconomic burdenPreeclampsiaCurrent professional guidelinesRisk assessment strategiesRisk assessmentPractice changeDifferent assessment toolsSpecific knowledge gapsAspirinUnited StatesTarget populationConsequent interventionsFeasibility of implementationProfessional guidelinesAssessment toolAvailable literatureRisk
2008
Stillbirth at Term in Women of Advanced Maternal Age in the United States: When Could the Antenatal Testing Be Initiated?
Bahtiyar M, Funai E, Rosenberg V, Norwitz E, Lipkind H, Buhimschi C, Copel J. Stillbirth at Term in Women of Advanced Maternal Age in the United States: When Could the Antenatal Testing Be Initiated? American Journal Of Perinatology 2008, 25: 301-304. PMID: 18437644, DOI: 10.1055/s-2008-1076605.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleFetal DeathHumansMaternal AgeRisk FactorsStillbirthTerm BirthUnited StatesConceptsIntrauterine fetal demiseAdvanced maternal ageYears of ageRisk of IUFDAntenatal testingMaternal ageSingleton term deliveriesTerm singleton gestationsProportional hazards modelSingleton gestationsFetal demiseIndependent predictorsMedical complicationsTerm deliveryWomen 25Women 40Risk factorsMaternal raceCongenital anomaliesPrevention databaseHazards modelHaenszel testWomen 15U.S. CentersCochran-Mantel
2002
Midtrimester nuchal thickness and the prediction of postnatal congenital heart defect
Bahado-Singh RO, Rowther M, Bailey J, Copel J, Mendilcioglu I, Choi S, Oz U. Midtrimester nuchal thickness and the prediction of postnatal congenital heart defect. American Journal Of Obstetrics And Gynecology 2002, 187: 1250-1253. PMID: 12439514, DOI: 10.1067/mob.2002.128025.Peer-Reviewed Original ResearchConceptsNuchal thickness measurementPrediction of CHDNuchal thicknessRisk factorsHeart defectsStepwise logistic regression analysisBackground population riskIndividual patient's riskEpidemiologic risk factorsSignificant risk factorsMultiple risk factorsPatient-specific riskSignificant predictorsLogistic regression analysisCongenital heart defectsOnly significant predictorMajor CHDPostnatal evaluationPatient riskMidtrimester fetusesNormal fetusesCongenital heartCHDLogistic regression
2001
Can Risk Factor Assessment Replace Universal Screening for Gonorrhea and Chlamydia in the Third Trimester?
Magriples U, Copel J. Can Risk Factor Assessment Replace Universal Screening for Gonorrhea and Chlamydia in the Third Trimester? American Journal Of Perinatology 2001, 18: 465-468. PMID: 11733863, DOI: 10.1055/s-2001-18790.Peer-Reviewed Original ResearchConceptsThird trimesterPrenatal careInitial negative testNegative initial screenRisk factor screeningThird-trimester testingUrban clinic populationFirst prenatal visitHistory of STDNegative predictive valueAbsence of RFRF screeningPrenatal visitChlamydia screeningGestational agePositive RFStudy criteriaClinic populationClinic settingUniversal screeningLower riskProspective analysisNegative testPredictive valueDrug use
1999
Selective Screening for Gestational Diabetes Mellitus in Adolescent Pregnancies
KHINE M, WINKLESTEIN A, COPEL J. Selective Screening for Gestational Diabetes Mellitus in Adolescent Pregnancies. Obstetrics And Gynecology 1999, 93: 738-742. DOI: 10.1097/00006250-199905000-00020.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusBody mass indexAdolescent gravidasRisk factorsGestational diabetesRace/ethnicityDiabetes mellitusMass indexHigh prevalenceFamily historyMedical disordersBasis of BMIPrevalence of GDMAdolescent pregnancySelective screeningConclusion Body mass indexGDM risk factorsPrevious obstetric historyImportant risk factorStudent's t-testObstetric historyAdolescent patientsDiseases codesAnomalous fetusesInternational ClassificationGestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk
Bahado‐Singh R, Oz U, Kovanci E, Deren O, Feather M, Hsu C, Copel J, Mahoney M. Gestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk. The Journal Of Maternal-Fetal Medicine 1999, 8: 37-43. PMID: 10090488, DOI: 10.1002/(sici)1520-6661(199903/04)8:2<37::aid-mfm1>3.0.co;2-p.Peer-Reviewed Original ResearchA new splenic artery Doppler velocimetric index for prediction of severe fetal anemia associated with Rh alloimmunization
Bahado-Singh R, Oz U, Deren O, Pirhonen J, Kovanci E, Copel J, Onderoglu L. A new splenic artery Doppler velocimetric index for prediction of severe fetal anemia associated with Rh alloimmunization. American Journal Of Obstetrics And Gynecology 1999, 180: 49-54. PMID: 9914577, DOI: 10.1016/s0002-9378(99)70148-1.Peer-Reviewed Original ResearchConceptsMain splenic arterySevere fetal anemiaSevere anemiaHemoglobin deficitFetal anemiaSplenic arteryGestational ageDoppler velocimetric indicesDevelopment of hydropsNew Doppler indexVelocimetric indicesCase patientsDoppler indicesRh alloimmunizationRh sensitizationHealthy fetusesAnemiaFalse positive rateNoninvasive predictionDiastolic phaseAnemia detectionDoppler velocimetrySignificant correlationArteryCordocentesis
1998
Accurate detection of anomalies by routine ultrasonography in an indigent clinic population
Magriples U, Copel J. Accurate detection of anomalies by routine ultrasonography in an indigent clinic population. American Journal Of Obstetrics And Gynecology 1998, 179: 978-981. PMID: 9790383, DOI: 10.1016/s0002-9378(98)70201-7.Peer-Reviewed Original ResearchConceptsVentricular septal defectScreening ultrasonographyRoutine ultrasonographyClinic populationSeptal defectRoutine screening ultrasonographyImmediate neonatal periodTermination of pregnancyPositive predictive valueMisshapen earsNeonatal chartsExtralobar sequestrationGroup of sonographersWeeks' gestationGreat arteriesNeonatal periodRetrospective studyResident clinicUltrasonographic resultsImperforate anusIndigent populationObstetric ultrasonographyFetal monitoringUltrasonographyPredictive valueCan Risk Factor Screening Predict Hepatitis C Antibody Reactivity?
Magriples U, Bernstein P, Snyder E, Copel J. Can Risk Factor Screening Predict Hepatitis C Antibody Reactivity? American Journal Of Perinatology 1998, 15: 395-398. PMID: 9722062, DOI: 10.1055/s-2007-993964.Peer-Reviewed Original ResearchConceptsHepatitis C virusPercent of womenRisk factorsEnzyme-linked immunoadsorbent assaySecond-generation testingHistory of hepatitisIntravenous drug useNegative predictive valueHCV exposureRF screeningConsecutive patientsProspective studyC virusLower riskAntibody reactivityPredictive valueDrug useImmunoadsorbent assayWomenPatientsScreeningAssaysPercentHepatitisPrevalence
1996
Ultrasonographically adjusted midtrimester risk of trisomy 21 and significant chromosomal defects in advanced maternal age
Bahado-Singh R, Deren Ö, Tan A, D'Ancona R, Hunter D, Copel J, Mahoney M. Ultrasonographically adjusted midtrimester risk of trisomy 21 and significant chromosomal defects in advanced maternal age. American Journal Of Obstetrics And Gynecology 1996, 175: 1563-1568. PMID: 8987942, DOI: 10.1016/s0002-9378(96)70107-2.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageMaternal ageDown syndromeNormal ultrasonographyUltrasonography resultsAbdominal circumferenceNuchal thicknessAnatomic defectsChromosomal defectsSmaller abdominal circumferenceChoroid plexus cystsFetal Down syndromeReceiver operator characteristic curveStepwise logistic regressionAbnormal ultrasonography resultsBasis of ageDown syndrome detectionUltrasonographic resultsNormal groupChromosome defectsBiparietal diameterRisk tablesTrisomy 21SyndromeShort humerusIs the fetal brain‐sparing effect a risk factor for the development of intraventricular hemorrhage in the preterm infant?
Mari G, Abuhamad A, Keller M, Verpairojkit B, Ment L, Copel J. Is the fetal brain‐sparing effect a risk factor for the development of intraventricular hemorrhage in the preterm infant? Ultrasound In Obstetrics And Gynecology 1996, 8: 329-332. PMID: 8978007, DOI: 10.1046/j.1469-0705.1996.08050329.x.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery pulsatility indexCerebral artery pulsatility indexBrain-sparing effectArtery pulsatility indexIntrauterine growth restrictionIntraventricular hemorrhagePulsatility indexPreterm laborAntenatal exposureGestational ageMean birth weightNeonatal intraventricular hemorrhageRespiratory distress syndromeMiddle cerebral arteryFirst postnatal weekApgar scoreCesarean sectionNecrotizing enterocolitisPreterm infantsBrain sparingDistress syndromeWeeks' gestationCerebral arteryIUGR fetusesDoppler studiesRisk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results
Bahado-Singh R, Tan A, Deren O, Hunter D, Copel J, Mahoney M. Risk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results. American Journal Of Obstetrics And Gynecology 1996, 175: 824-829. PMID: 8885729, DOI: 10.1016/s0002-9378(96)80006-8.Peer-Reviewed Original Research
1995
Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results
Bahado-Singh R, Goldstein I, Uerpairojkit B, Copel J, Mahoney M, Baumgarten A. Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results. American Journal Of Obstetrics And Gynecology 1995, 173: 1106-1110. PMID: 7485301, DOI: 10.1016/0002-9378(95)91334-3.Peer-Reviewed Original ResearchConceptsAbnormal triple-screen resultsTriple-screen resultsNuchal thicknessDown syndromeHuman chorionic gonadotropin levelsNuchal thickness measurementChorionic gonadotropin levelsReceiver operator characteristic curveNumber of amniocentesesReceiver operator characteristic plotsRisk thresholdMidtrimester pregnancyGonadotropin levelsWeeks' gestationMaternal ageConsecutive fetusesUnconjugated estriolSerum screeningEuploid fetusesAlpha-fetoproteinSyndromeTrisomy 21Screen resultsRisk estimatesFetusesManagement of the Rh-Sensitizeo Mother
Gollin Y, Copel J. Management of the Rh-Sensitizeo Mother. Clinics In Perinatology 1995, 22: 545-559. PMID: 8521681, DOI: 10.1016/s0095-5108(18)30268-9.ChaptersMeSH KeywordsAnemiaFemaleFetal DiseasesHumansPregnancyPregnancy Complications, HematologicRh IsoimmunizationRisk FactorsConceptsRh immune globulinManagement of complicationsRh D typingEarly referralIntrauterine transfusionImmune globulinRh isoimmunizationTertiary centerAnemic fetusesNeonatal careFetal bloodInvasive techniquesLung maturityPrompt identificationD typingClinical situationsOptimal managementFetusesMothersTransfusionComplicationsIsoimmunizationNeonatesNeonatologistsPerinatologists
1993
Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. comparison of enzyme‐linked immunosorbent assay and immunoblot for measurement of anti–ss‐a/ro and anti–ss‐b/la antibodies
Buyon J, Winchester R, Slade S, Arnett F, Copel J, Friedman D, Lockshin M. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. comparison of enzyme‐linked immunosorbent assay and immunoblot for measurement of anti–ss‐a/ro and anti–ss‐b/la antibodies. Arthritis & Rheumatism 1993, 36: 1263-1273. PMID: 8216420, DOI: 10.1002/art.1780360911.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayNeonatal lupus syndromeNeonatal lupusCongenital heart blockHeart blockSDS-immunoblotRo antibodiesHealthy infantsMothers of childrenLupus syndromeLa antibodiesFetal deathAutoimmune diseasesRo antigenRo responseDetectable cardiac involvementFetal death groupSystemic lupus erythematosusSpecific antibody profileMothers of infantsRelated autoimmune diseasesIdentification of mothersEnzyme-linked immunosorbentFine specificity patternsGroups of mothers
1988
The frequency of aneuploidy in prenatally diagnosed congenital heart disease: An indication for fetal karyotyping
Copel J, Cullen M, Green J, Mahoney M, Hobbins J, Kleinman C. The frequency of aneuploidy in prenatally diagnosed congenital heart disease: An indication for fetal karyotyping. American Journal Of Obstetrics And Gynecology 1988, 158: 409-413. PMID: 3341415, DOI: 10.1016/0002-9378(88)90166-4.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseHeart diseaseFetal heart diseaseFrequency of aneuploidyNeonatal careCardiac anomaliesFetal echocardiogramPediatric literatureFetal karyotypingParental counselingFetal bloodNonviable fetusClinic dataCase identificationChromosomal abnormalitiesFetusesDiseaseAbnormal chromosomesChromosome analysisEchocardiogramInfantsUteroWorkupAbnormalitiesAmniocentesisDiagnostic fetal umbilical blood sampling in the management of isoimmunization
Reece E, Copel J, Scioscia A, Grannum P, DeGennaro N, Hobbins J. Diagnostic fetal umbilical blood sampling in the management of isoimmunization. American Journal Of Obstetrics And Gynecology 1988, 159: 1057-1062. PMID: 3142263, DOI: 10.1016/0002-9378(88)90412-7.Peer-Reviewed Original ResearchConceptsAntigen-positive fetusesFetal hemolytic diseaseFetal umbilical bloodManagement of isoimmunizationEarlier gestational ageMultiple invasive proceduresIsoimmunized pregnanciesFetal anemiaAntigen statusGestational ageUmbilical bloodHemolytic diseaseFetal bloodInvasive proceduresCurrent managementFetusesPreliminary reportPregnancyIsoimmunizationDiseaseManagement protocolDiagnosisBloodLittle riskTreatment