2023
ISUOG Practice Guidelines (updated): fetal cardiac screening
Carvalho J, Axt‐Fliedner R, Chaoui R, Copel J, Cuneo B, Goff D, Kopylov L, Hecher K, Lee W, Moon‐Grady A, Mousa H, Munoz H, Paladini D, Prefumo F, Quarello E, Rychik J, Tutschek B, Wiechec M, Yagel S. ISUOG Practice Guidelines (updated): fetal cardiac screening. Ultrasound In Obstetrics And Gynecology 2023, 61: 788-803. PMID: 37267096, DOI: 10.1002/uog.26224.Peer-Reviewed Original Research
2022
Maternal-fetal medicine fellows’ perception and comfort with obstetrical ultrasound and prenatal diagnosis
Holliman K, Pluym ID, Grechukhina O, Blumenfeld YJ, Platt LD, Copel JA, Han CS. Maternal-fetal medicine fellows’ perception and comfort with obstetrical ultrasound and prenatal diagnosis. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100601. PMID: 35217235, DOI: 10.1016/j.ajogmf.2022.100601.Peer-Reviewed Original Research
2013
ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart
International Society of Ultrasound in Obstetrics and Gynecology, Carvalho J, Allan L, Chaoui R, Copel J, DeVore G, Hecher K, Lee W, Munoz H, Paladini D, Tutschek B, Yagel S. ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart. Ultrasound In Obstetrics And Gynecology 2013, 41: 348-359. PMID: 23460196, DOI: 10.1002/uog.12403.Commentaries, Editorials and Letters
2001
Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient
Verheijen P, Lisowski L, Stoutenbeek P, Hitchcock J, Brenner J, Copel J, Kleinman C, Meijboom E, Bennink G. Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient. Journal Of Thoracic And Cardiovascular Surgery 2001, 121: 798-803. PMID: 11279423, DOI: 10.1067/mtc.2001.112825.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseHeart diseaseLower base excessHeart obstructionMetabolic acidosisBase excessDuctus-dependent congenital heart diseasePrenatal diagnosisPostnatal diagnosisImproved long-term outcomesGroup of patientsArterial blood gasesLong-term outcomesCause of deathHigher lactate levelsDays of lifePrevention of acidosisSignificant differencesBiventricular repairPreoperative conditionCerebral damageRetrospective studySurgical outcomesPreoperative acidosisBlood gases
2000
Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation
Bahado‐Singh R, Oz A, Gomez K, Hunter D, Copel J, Baumgarten A, Mahoney M. Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation. Ultrasound In Obstetrics And Gynecology 2000, 15: 199-204. PMID: 10846774, DOI: 10.1046/j.1469-0705.2000.00071.x.Peer-Reviewed Original ResearchConceptsMaternal ageAlpha-fetoproteinTriple screenSerum markersUltrasound biometryDown syndromeNuchal thickness measurementMedian maternal ageSerum alpha-fetoproteinNormal singleton pregnanciesHumerus lengthGestational age rangeDown's syndrome screening efficiencySingleton pregnanciesReferral populationFalse positive rateSecond trimesterIndividual Down syndrome oddsFetal biometryUnconjugated estriolStudy groupNuchal thicknessDown syndrome risk estimationHCGAge range
1999
Prenatal Screening for Down's Syndrome — A Search for the Family's Values
Copel J, Bahado-Singh R. Prenatal Screening for Down's Syndrome — A Search for the Family's Values. New England Journal Of Medicine 1999, 341: 521-522. PMID: 10441609, DOI: 10.1056/nejm199908123410709.Commentaries, Editorials and LettersSelective Screening for Gestational Diabetes Mellitus in Adolescent Pregnancies
KHINE M, WINKLESTEIN A, COPEL J. Selective Screening for Gestational Diabetes Mellitus in Adolescent Pregnancies. Obstetrics And Gynecology 1999, 93: 738-742. DOI: 10.1097/00006250-199905000-00020.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusBody mass indexAdolescent gravidasRisk factorsGestational diabetesRace/ethnicityDiabetes mellitusMass indexHigh prevalenceFamily historyMedical disordersBasis of BMIPrevalence of GDMAdolescent pregnancySelective screeningConclusion Body mass indexGDM risk factorsPrevious obstetric historyImportant risk factorStudent's t-testObstetric historyAdolescent patientsDiseases codesAnomalous fetusesInternational ClassificationA high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome risk
1998
New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age
Bahado-Singh R, Oz A, Kovanci E, Deren O, Copel J, Baumgarten A, Mahoney J. New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age. American Journal Of Obstetrics And Gynecology 1998, 179: 1627-1631. PMID: 9855608, DOI: 10.1016/s0002-9378(98)70036-5.Peer-Reviewed Original ResearchConceptsHumerus length measurementsSerum markersDown syndromeMaternal ageTriple screenHumerus lengthMultiple stepwise logistic regression analysisTriple-marker serum screeningSerum analytesStepwise logistic regression analysisScreening algorithmHigh-risk populationFetal Down syndromeMultiple serum markersDown syndrome screeningHuman chorionic gonadotropinLogistic regression analysisNew screening algorithmDown's syndrome screening efficiencyPrenatal Down syndrome screeningDown syndrome detectionFalse positive rateSerum screenSingleton fetusesUnconjugated estriolNew triple screen test for Down syndrome: Combined urine analytes and serum AFP
Bahado‐Singh R, Oz U, Kovanci E, Cermik D, Flores D, Copel J, Mahoney M, Cole L. New triple screen test for Down syndrome: Combined urine analytes and serum AFP. The Journal Of Maternal-Fetal Medicine 1998, 7: 111-114. PMID: 9642606, DOI: 10.1002/(sici)1520-6661(199805/06)7:3<111::aid-mfm2>3.0.co;2-n.Peer-Reviewed Original ResearchConceptsSerum AFPIndividual Down syndrome oddsMaternal ageTriple screenUrine beta-core fragmentDown syndromeTriple testTriple screen testBeta-core fragmentDown syndrome casesNeural tube defectsDown's syndrome likelihood ratiosEstriol levelsLarge trialsSecond trimesterUrine testsPositive rateEstriol ratioSyndrome casesTube defectsScreen testFalse positive rateAFP dataUrine analytesAFP
1997
MANAGEMENT OF FETAL CARDIAC ARRHYTHMIAS
Copel J, Friedman A, Kleinman C. MANAGEMENT OF FETAL CARDIAC ARRHYTHMIAS. Obstetrics And Gynecology Clinics Of North America 1997, 24: 201-211. PMID: 9086526, DOI: 10.1016/s0889-8545(05)70297-7.Chapters
1996
Nicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening
Rotmensch S, Liberati M, Kardana A, Copel J, Ben-Rafael Z, Cole L. Nicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening. American Journal Of Obstetrics And Gynecology 1996, 174: 609-611. PMID: 8623792, DOI: 10.1016/s0002-9378(96)70435-0.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinDown syndrome screeningChorionic gonadotropinSyndrome pregnanciesSyndrome screeningFree beta subunitMaternal serum levelsDown syndrome pregnanciesPotential new markerFree β-subunitSerum levelsNormal controlsSensitive markerImmunoenzymometric assaySerum specimensDown syndromeGonadotropinMean levelsNew markersPreliminary dataMedianPregnancyCase levelMarkersΒ-subunit
1995
In Utero identification and therapy of congenital heart block
Buyon J, Waltuck J, Kleinman C, Copel J. In Utero identification and therapy of congenital heart block. Lupus 1995, 4: 116-121. PMID: 7795614, DOI: 10.1177/096120339500400207.Peer-Reviewed Original ResearchMeSH KeywordsDexamethasoneEchocardiographyFemaleHeart BlockHumansPrednisonePregnancyPrenatal DiagnosisConceptsCongenital heart blockWeeks of gestationHeart blockFluorinated steroidsDegree blockEarly third trimesterSecond-degree blockThird-degree blockDegree of blockDisease activityChart reviewPericardial effusionPrimary physicianThird trimesterSinus rhythmUtero identificationGestational periodPrenatal therapyFetal vulnerabilityPregnancyTiming of identificationTherapyMid secondWeeksPrednisoneThe predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization
Moise K, Perkins J, Sosler S, Brown S, Saade G, Carpenter R, Thorp J, Ludomirski A, Wilkins I, Grannum P, Copel J. The predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization. American Journal Of Obstetrics And Gynecology 1995, 172: 1003-1009. PMID: 7892839, DOI: 10.1016/0002-9378(95)90034-9.Peer-Reviewed Original ResearchConceptsRed blood cell alloimmunizationFetal anemiaMarsh scoreReceiver operator characteristic curveCoombs titersRed blood cell antibodiesMaternal antibody titersGroups of fetusesMaternal serum testingCharacteristic curveMaternal serum testsMaternal titersCell antibodiesAntigen statusGestational agePregnant womenAntibody titersSerum testingSerum testFetal hematocritInvasive testingFetal bloodKruskal-Wallis testAnemiaFetal disease
1992
Outcome of prenatally detected cardiac malformations
Smythe J, Copel J, Kleinman C. Outcome of prenatally detected cardiac malformations. The American Journal Of Cardiology 1992, 69: 1471-1474. PMID: 1590238, DOI: 10.1016/0002-9149(92)90903-c.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, EugenicChild, PreschoolFetal DeathFollow-Up StudiesHeart Defects, CongenitalHumansInfantInfant, NewbornPrenatal DiagnosisPrognosisConceptsCardiac failureExtracardiac malformationsMajor extracardiac malformationsCongenital heart diseaseCardiac lesionsOptimal counselingNonimmune hydropsElective terminationExtracardiac defectsFetal echocardiographyHeart diseaseCardiac malformationsCardiac defectsChromosomal abnormalitiesMalformationsPrenatal detectionPregnancyPatientsOutcomesEchocardiographyHydropsPrognosisFailureLesionsAbnormalities
1991
Can umbilical artery pulsatility index predict the outcome of fetuses with structural heart disease?
Copel J, Hobbins J, Kleinman C. Can umbilical artery pulsatility index predict the outcome of fetuses with structural heart disease? Journal Of Ultrasound In Medicine 1991, 10: 323-326. PMID: 1895374, DOI: 10.7863/jum.1991.10.6.323.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseElevated pulsatility indexPulsatility indexHeart diseaseUmbilical artery PI valuesUmbilical artery pulsatility indexUmbilical artery Doppler waveformsNormal PI valuesArtery pulsatility indexOutcome of fetusesStructural heart diseaseEnd-diastolic velocityWeeks' gestationFatal anomalyCHD fetusesAnomalous fetusesDoppler waveformsFatal diseaseFetusesNormal populationDiseasePI valuesGestationNormal chromosomesLesionsPerinatal outcome of fetal complete atrioventricular block: A multicenter experience
Schmidt K, Ulmer H, Silverman N, Kleinman C, Copel J. Perinatal outcome of fetal complete atrioventricular block: A multicenter experience. Journal Of The American College Of Cardiology 1991, 17: 1360-1366. PMID: 2016455, DOI: 10.1016/s0735-1097(10)80148-2.Peer-Reviewed Original ResearchConceptsComplete atrioventricular blockBeats/minStructural heart defectsAtrial isomerismAtrioventricular blockVentricular rateAV blockAtrial rateHeart defectsFetal complete atrioventricular blockDiscordant AV connectionsLeft atrial isomerismConnective tissue diseaseNormal cardiac anatomySecond-degree blockComplete AV blockComplex structural heart defectsSlow atrial rateAntinuclear antibodiesPerinatal outcomesAV connectionsMulticenter experienceClinical courseNeonatal deathTissue disease
1990
Invasive Fetal Assessment in the Antepartum Period
Copel J, Gullen M, Grannum P, Hohbins J. Invasive Fetal Assessment in the Antepartum Period. Obstetrics And Gynecology Clinics Of North America 1990, 17: 201-221. PMID: 2192320, DOI: 10.1016/s0889-8545(21)00473-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1989
Fetal Behavior in Preterm Premature Rupture of the Membranes
Goldstein I, Copel J, Hobbins J. Fetal Behavior in Preterm Premature Rupture of the Membranes. Clinics In Perinatology 1989, 16: 735-754. PMID: 2673615, DOI: 10.1016/s0095-5108(18)30629-8.Peer-Reviewed Original ResearchPulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancy
Copel J, Grannum P, Green J, Belanger K, Hobbins J. Pulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancy. American Journal Of Obstetrics And Gynecology 1989, 161: 341-344. PMID: 2504040, DOI: 10.1016/0002-9378(89)90516-4.Peer-Reviewed Original Research